公开(公告)号：US06518066B1

公开(公告)日：2003-02-11

申请号：US09608958

申请日：2000-06-30

申请人： Tim N. Oulmassov ,  Kevin E. McBride ,  Paula C. Miller ,  John C. Anderson ,  Lyle D. Crossland ,  Thomas H. Adams ,  Barbara A. Qurollo ,  Victoria Gavrias

发明人： Tim N. Oulmassov ,  Kevin E. McBride ,  Paula C. Miller ,  John C. Anderson ,  Lyle D. Crossland ,  Thomas H. Adams ,  Barbara A. Qurollo ,  Victoria Gavrias

IPC分类号： C12N1582

CPC分类号： C07D307/33 ,  A61K48/00 ,  C12N15/81 ,  C12N15/8214 ,  C12N15/8216 ,  C12N15/8217 ,  C12N15/8238 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/001 ,  C12N2830/002 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/36 ,  C12N2840/105 ,  C12N2840/20 ,  C12N2840/203

摘要： DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.

公开(公告)号：US07202085B2

公开(公告)日：2007-04-10

申请号：US11145451

申请日：2005-06-03

申请人： Tim N. Oulmassov ,  Kevin E. McBride ,  Paula C. Miller ,  John C. Anderson ,  Lyle D. Crossland ,  Thomas H. Adams ,  Barbara A. Qurollo ,  Victoria Gavrias

发明人： Tim N. Oulmassov ,  Kevin E. McBride ,  Paula C. Miller ,  John C. Anderson ,  Lyle D. Crossland ,  Thomas H. Adams ,  Barbara A. Qurollo ,  Victoria Gavrias

IPC分类号： C12N5/14 ,  C12N5/10 ,  A01H5/00

CPC分类号： C07D307/33 ,  A61K48/00 ,  C12N15/81 ,  C12N15/8214 ,  C12N15/8216 ,  C12N15/8217 ,  C12N15/8238 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/001 ,  C12N2830/002 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/36 ,  C12N2840/105 ,  C12N2840/20 ,  C12N2840/203

摘要： DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.

摘要翻译： 用于控制真核细胞和生物体中的基因表达的DNA构建体和其它组合物和方法源自细菌群体感测系统。 来自luxI启动子的一种或多种顺式元件（“lux框”）或功能上相似的序列并入真核启动子中。 来自转录调节物的LuxR家族的受体蛋白质在结合酰化的高丝氨酸内酯（AHL）化合物时，与lux框相互作用，调节启动子的活性。

公开(公告)号：US06943243B2

公开(公告)日：2005-09-13

申请号：US10360123

申请日：2003-02-06

申请人： Tim N. Oulmassov ,  Kevin E. McBride ,  Paula C. Miller ,  John C. Anderson ,  Lyle D. Crossland ,  Thomas H. Adams ,  Barbara A. Qurollo ,  Victoria Gavrias

发明人： Tim N. Oulmassov ,  Kevin E. McBride ,  Paula C. Miller ,  John C. Anderson ,  Lyle D. Crossland ,  Thomas H. Adams ,  Barbara A. Qurollo ,  Victoria Gavrias

IPC分类号： A01H5/00 ,  A01K67/027 ,  A61K31/7088 ,  A61K48/00 ,  A61P31/00 ,  C07D307/33 ,  C07H21/04 ,  C12N1/19 ,  C12N5/04 ,  C12N5/10 ,  C12N9/18 ,  C12N15/09 ,  C12N15/81 ,  C12N15/82 ,  C12N15/85 ,  C12Q1/02 ,  C12Q1/68 ,  C12N5/14

CPC分类号： C07D307/33 ,  A61K48/00 ,  C12N15/81 ,  C12N15/8214 ,  C12N15/8216 ,  C12N15/8217 ,  C12N15/8238 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/001 ,  C12N2830/002 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/36 ,  C12N2840/105 ,  C12N2840/20 ,  C12N2840/203

摘要： DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.

摘要翻译： 用于控制真核细胞和生物体中的基因表达的DNA构建体和其它组合物和方法源自细菌群体感测系统。 来自luxI启动子的一种或多种顺式元件（“lux框”）或功能上相似的序列并入真核启动子中。 来自转录调节物的LuxR家族的受体蛋白质在结合酰化的高丝氨酸内酯（AHL）化合物时，与lux框相互作用，调节启动子的活性。

公开(公告)号：US06297194B1

公开(公告)日：2001-10-02

申请号：US09497017

申请日：2000-02-02

申请人： Paula C. Miller ,  Jane M. Curtis ,  John M. Molyneaux ,  Thomas J. Owen

发明人： Paula C. Miller ,  Jane M. Curtis ,  John M. Molyneaux ,  Thomas J. Owen

IPC分类号： A01N5724

CPC分类号： A01N57/24 ,  A01N57/32 ,  C07F9/65031

摘要： Pyrazole compounds with activity as chemical hybridizing agents and methods for synthesis of such compounds are disclosed. These compounds are useful in producing hybrid wheat (Triticum aesativum) and other crops.

摘要翻译： 公开了具有作为化学杂交剂活性的吡唑化合物及其合成方法。 这些化合物可用于生产杂交小麦（Triticum aesativum）和其他作物。