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    Markers for invasive prostatic neoplasia
    1.
    发明授权
    Markers for invasive prostatic neoplasia 失效
    侵袭性前列腺肿瘤标志物

    公开(公告)号：US5424192A

    公开(公告)日：1995-06-13

    申请号：US38491

    申请日：1993-03-29

    申请人： Timothy C. Thompson ,  Thomas P. Dooley

    发明人： Timothy C. Thompson ,  Thomas P. Dooley

    IPC分类号： G01N33/574 ,  G01N33/53

    CPC分类号： G01N33/57434 ,  G01N33/57484 ,  Y10S436/813

    摘要： This invention is directed to the identification, isolation and use of nonprostate derived markers, such as markers derived from the seminal vesicles, and antibodies which recognize these markers in the diagnosis of invasive proatic neoplasia, to diagnostic aids for screening biological samples for evidence of invasive prostatic neoplasia, and to methods for the use of these diagnostic aids.

    摘要翻译： 本发明涉及鉴定，分离和使用非前列腺衍生标记物，例如来源于精囊的标志物，以及识别这些标志物在侵入性原发性肿瘤诊断中的抗体，用于筛选生物样品用于侵入性证据的诊断辅助物 前列腺增生症，以及使用这些诊断辅助工具的方法。

    Systems and processes for forming anatomical features in dentures
    3.
    发明授权
    Systems and processes for forming anatomical features in dentures 有权
    用于形成义齿解剖特征的系统和过程

    公开(公告)号：US09402698B2

    公开(公告)日：2016-08-02

    申请号：US12939138

    申请日：2010-11-03

    申请人： Timothy C. Thompson ,  Scott C. Keating ,  Andrzej J. Jakson

    发明人： Timothy C. Thompson ,  Scott C. Keating ,  Andrzej J. Jakson

    IPC分类号： A61C13/00 ,  A61K6/083 ,  A61C13/24 ,  G06T19/00 ,  A61C9/00 ,  A61C13/01 ,  G06F17/50

    CPC分类号： G06F17/50 ,  A61C9/0046 ,  A61C13/0004 ,  A61C13/01

    摘要： The system of a preferred embodiment uses a process whereby a true replication of the patient's jaw structure is created in a digital three dimensional model. This true replication is then used to precisely locate and/or copy the anatomical landmarks of the patient for use in fabricating a denture base for use in a denture for the individual patient. This system is able to to create a denture with precisely located features corresponding to the anatomical landmarks of the patient with little manual intervention.

    摘要翻译： 优选实施例的系统使用一种过程，由此在数字三维模型中创建患者的颌骨结构的真实复制。 然后使用这种真正的复制来精确地定位和/或复制患者的解剖标志，以用于制造用于单个患者的假牙的义齿基座。 该系统能够以很少的手动干预来创建具有与患者的解剖标志相对应的精确定位的特征的义齿。

    System and Processes for Optimization for Dentures
    4.
    发明申请
    System and Processes for Optimization for Dentures 审中-公开
    假牙优化的系统和过程

    公开(公告)号：US20160008108A1

    公开(公告)日：2016-01-14

    申请号：US12939141

    申请日：2010-11-03

    申请人： Timothy C. Thompson ,  Scott C. Keating ,  Andrzej J. Jakson

    发明人： Timothy C. Thompson ,  Scott C. Keating ,  Andrzej J. Jakson

    IPC分类号： A61C13/00 ,  G06N5/04 ,  A61C13/107 ,  A61C13/10 ,  A61C19/05 ,  A61C13/34

    CPC分类号： A61C13/0001 ,  A61C13/0004 ,  A61C13/10 ,  A61C13/34 ,  A61C19/05 ,  G06N5/046

    摘要： System and processes for optimal selection and design of teeth for dentures based on the anatomical measurements and bite impressions of the patient. This information is applied in an iterative manner to rules that balance the anatomical, functional and aesthetic considerations to select the best teeth for a patient. The system may also use this information in an iterative manner to rules that balance the anatomical, functional and aesthetic considerations to design the optimal denture teeth and base for the patient as well.

    摘要翻译： 基于患者的解剖学测量和咬伤印象，用于假牙齿优化选择和设计的系统和过程。 该信息以迭代的方式应用于平衡解剖学，功能和美学考虑因素以选择患者最佳牙齿的规则。 系统还可以以迭代的方式将这些信息用于平衡解剖学，功能和美学考虑因素以规定患者的最佳义齿和基础的规则。

    RTVP based compositions and methods for the treatment of prostate cancer
    5.
    发明授权
    RTVP based compositions and methods for the treatment of prostate cancer 有权
    基于RTVP的组合物和治疗前列腺癌的方法

    公开(公告)号：US07645452B2

    公开(公告)日：2010-01-12

    申请号：US10417727

    申请日：2003-04-17

    申请人： Timothy C. Thompson ,  Chengzhen Ren

    发明人： Timothy C. Thompson ,  Chengzhen Ren

    IPC分类号： A61K39/00

    CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K39/00 ,  C07K14/705

    摘要： This invention relates to a gene encoding RTVP that has been shown to be up-regulated by p53 using differential display-PCR and subsequently by co-transfection studies. RTVP-1 mRNA is abundant in normal mouse and human prostatic epithelial cells and primary tumors, but is significantly down regulated in metastatic mouse and human prostate cancer. In prostate cancer cells overexpression of the mouse RTVP-1 gene (mRTVP-1) induced apoptosis that was accompanied by increased caspase 8, 9 and 3 activities. mRTVP-1-stimulated apoptosis was also associated with increased levels of bax, bad and activated BID; reduced levels of bcl-2 and bcl-XL; and cytosolic cytochrome c accumulation. Adenoviral-vector-mediated mRTVP-1 expression lead to potent growth suppression and antimetastatic activities in an orthotopic mouse model of prostate cancer in vivo. These therapeutic activities were associated with anti-angiogenic effects and importantly a local and systemic immune response. Accordingly, p53 was linked with suppression of metastasis through its induction of mRTVP-1, which can concurrently induce apoptosis, suppress angiogenesis and stimulate an antitumor immune response. Thus, the invention includes compositions and methods, based on RTVP nucleic acid, polypeptides, and antibodies, for use in the treatment, prevention and detection of neoplastic disease and, specifically, metastatic prostatic neoplasia.

    摘要翻译： 本发明涉及编码RTVP的基因，已被证明是通过差异显示PCR而被p53上调，随后通过共转染研究。 RTVP-1 mRNA在正常小鼠和人前列腺上皮细胞和原发性肿瘤中丰富，但在转移性小鼠和人前列腺癌中显着下调。 在前列腺癌细胞中，小鼠RTVP-1基因（mRTVP-1）的过表达诱导凋亡，其伴随着半胱天冬酶8,9和3活性的增加。 mRTVP-1刺激的细胞凋亡也与bax，坏和活化的BID水平升高相关; 降低bcl-2和bcl-XL的水平; 和胞质细胞色素C积累。 腺病毒载体介导的mRTVP-1表达导致在体内前列腺癌的原位小鼠模型中有效的生长抑制和抗转移活性。 这些治疗活动与抗血管生成作用相关，重要的是局部和全身免疫应答。 因此，p53通过诱导mRTVP-1与抑制转移相关，可以同时诱导凋亡，抑制血管发生和刺激抗肿瘤免疫反应。 因此，本发明包括基于RTVP核酸，多肽和抗体的组合物和方法，用于治疗，预防和检测肿瘤疾病，特别是转移性前列腺肿瘤。

    Systems and processes for forming anatomical features in dentures
    7.
    发明授权
    Systems and processes for forming anatomical features in dentures 有权
    用于形成义齿解剖特征的系统和过程

    公开(公告)号：US09155599B2

    公开(公告)日：2015-10-13

    申请号：US13823621

    申请日：2011-11-03

    申请人： Timothy C. Thompson ,  Scott C. Keating ,  Andrzej J. Jakson

    发明人： Timothy C. Thompson ,  Scott C. Keating ,  Andrzej J. Jakson

    IPC分类号： A61C13/00 ,  A61C13/01 ,  A61C13/10 ,  A61C9/00 ,  A61C13/34

    CPC分类号： A61C13/10 ,  A61C9/004 ,  A61C13/0004 ,  Y10T29/49567

    摘要： The system of a preferred embodiment uses a process whereby a true replication of the patient's jaw structure is created in a digital three dimensional model. This true replication is then used to precisely locate and/or copy the anatomical landmarks of the patient for use in fabricating a denture base for use in a denture for the individual patient. This system is able to create a denture with precisely located features corresponding to the anatomical landmarks of the patient with little manual intervention.

    摘要翻译： 优选实施例的系统使用一种过程，由此在数字三维模型中创建患者的颌骨结构的真实复制。 然后使用这种真正的复制来精确地定位和/或复制患者的解剖标志，以用于制造用于单个患者的假牙的义齿基座。 该系统能够以很少的手动干预来创建具有与患者的解剖标志相对应的精确定位的特征的义齿。

    SYSTEM AND PROCESS FOR OPTIMIZATION OF DENTURES
    8.
    发明申请
    SYSTEM AND PROCESS FOR OPTIMIZATION OF DENTURES 有权
    用于优化牙齿的系统和方法

    公开(公告)号：US20130218532A1

    公开(公告)日：2013-08-22

    申请号：US13823662

    申请日：2011-11-03

    申请人： Timothy C. Thompson ,  Scott C. Keating ,  Andrzej J. Jakson

    发明人： Timothy C. Thompson ,  Scott C. Keating ,  Andrzej J. Jakson

    IPC分类号： G06F17/50 ,  G06T17/00

    CPC分类号： G06T17/00 ,  A61C13/0004 ,  A61C13/0024 ,  B33Y80/00

    摘要： System and processes for optimal selection of teeth for dentures based on the anatomical measurements and bite impressions of the patient. This information is applied in an iterative manner to rules that balance the anatomical and aesthetic considerations to select the best teeth for a patient. The system may also use this information in an iterative manner to rules that balance the anatomical and aesthetic considerations to design the optimal denture base for the patient as well.

    摘要翻译： 基于患者的解剖学测量和咬伤印象，为假牙优化选择牙齿的系统和过程。 该信息以迭代的方式应用于平衡解剖学和美学考虑因素以选择患者最佳牙齿的规则。 系统还可以以迭代的方式将该信息用于平衡解剖学和美学考虑因素以规定患者的最佳义齿基础的规则。