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公开(公告)号：US5617860A
公开(公告)日：1997-04-08
申请号：US487137
申请日：1995-06-07
CPC分类号： A61K49/1815 , C01B23/00
摘要： A method and system for producing polarized .sup.129 Xe gas in an economical manner, allowing the polarized .sup.129 Xe gas to be used commercially in research and clinical applications. The production system of the present invention includes a holding tank for holding an unpolarized xenon gas/nitrogen gas mixture. The holding tank is in communication with a temperature controlled polarization chamber. A wide spectrum high power light source such as a diode laser array is in communication with the polarization chamber. The alkali metal vapor is optically pumped by the light source. The polarization chamber, which contains a given quantity of an alkali metal and its associated vapor, receives the gaseous mixture from the holding tank. The optically pumped alkali metal vapor atoms then collide with the xenon gas atoms, thus polarizing the xenon atoms. The entire gaseous mixture expands out of the polarization chamber into a device that separates the alkali metal vapor atoms from the polarized .sup.129 Xe atoms. The polarized .sup.129 Xe atoms are then controllably output to a system/user interface for application purposes.
摘要翻译： 以经济的方式生产极化的129Xe气体的方法和系统，允许极化的129Xe气体在商业上用于研究和临床应用。 本发明的生产系统包括用于保持非极化氙气/氮气混合物的容纳槽。 保持槽与温度控制的偏振室连通。 诸如二极管激光器阵列的宽频高功率光源与偏振腔连通。 碱金属蒸气由光源光泵浦。 包含给定量的碱金属及其相关蒸气的偏振腔从容纳槽接收气体混合物。 光泵浦的碱金属蒸汽原子然后与氙气原子碰撞，从而使氙原子偏振。 整个气态混合物从偏振腔中扩展成将碱金属蒸汽原子与极化的129Xe原子分离的装置。 然后将极化的129Xe原子可控地输出到用于应用目的的系统/用户界面。
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公开(公告)号：US6085743A
公开(公告)日：2000-07-11
申请号：US866138
申请日：1997-05-30
CPC分类号： G01R33/28 , A61M16/12 , A61M2202/0291 , G01R33/5601 , Y10S128/27
摘要： A system, and corresponding method, that interfaces with a gas polarization system to deliver a polarized noble gas to a subject for inhalation. Large volumes of polarized noble gas are obtained by repeated production/freezing cycles of a spin-exchange system. A storage cylinder is provided for storing a polarized noble gas. A gas delivery line is coupled to the storage cylinder and selectively delivers the polarized noble gas to the storage cylinder, and from the storage cylinder to the subject. A vacuum means is in communication with the gas delivery line for evacuating the storage cylinder in the gas delivery line prior to the noble gas being delivered thereto. A plurality of non-metallic gas delivery valves, located between the gas delivery line and the vacuum means, selectively control communication between the vacuum means and the polarized noble gas to minimize depolarization of the polarized noble gas during delivery of the noble gas to the subject on a breath-by-breath basis, or at a constant delivery rate. Control of remotely activated pneumatic valves allows complete automation of the polarization/accumulation/storage/delivery cycle for use in a low maintenance commercial device suitable for clinical and research applications. The polarization stage can be optimized for a particular noble gas species and particular application by the specific programming of the control electronics or computer.
摘要翻译： 与气体极化系统接合以将偏振的惰性气体输送到受试者进行吸入的系统和相应的方法。 通过自旋交换系统的反复生产/冷冻循环获得大量的极化惰性气体。 提供存储圆柱体用于存储极化的惰性气体。 气体输送管线联接到存储筒并且选择性地将偏振的惰性气体输送到存储缸，并且从存储缸向对象输送。 在惰性气体输送到真空装置之前，真空装置与气体输送管线连通，用于排出气体输送管线中的储存筒。 位于气体输送管线和真空装置之间的多个非金属气体输送阀选择性地控制真空装置和极化惰性气体之间的连通，以使惰性气体向主体输送期间极化惰性气体的去极化最小化 以呼吸为基础，或以恒定的传送速率。 远程激活的气动阀的控制允许完全自动化用于适用于临床和研究应用的低维护商业设备的偏振/积聚/存储/传送周期。 可以通过控制电子设备或计算机的特定编程，为特定惰性气体种类和特定应用优化极化阶段。
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