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公开(公告)号：US20120244189A1
公开(公告)日：2012-09-27
申请号：US13384234
申请日：2010-07-16
申请人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
发明人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
IPC分类号： A61K39/085 , C12N15/31 , C07K19/00 , C07K16/12 , A61P31/00 , A61P9/00 , A61P29/00 , A61P37/04 , C12N15/63 , C12N1/21 , A61P31/04 , C07K14/31 , A61P19/02
摘要： The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
摘要翻译： 本发明涉及改进的微生物抗原疫苗，药物组合物，免疫原性组合物和抗体及其在治疗微生物感染，特别是包括葡萄球菌来源的细菌来源的微生物感染中的用途。 理想地，本发明涉及与其宿主配体结合降低的重组葡萄球菌MSCRAMM或MSCRAMM样蛋白或其片段，用于治疗。
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2.发明授权Method of prophlactically treating infection using a recombinant fibrinogen binding protein clumping factor A (ClfA) or fragment thereof 有权使用重组纤维蛋白原结合蛋白凝聚因子A（ClfA）或其片段前体治疗感染的方法公开(公告)号：US09353160B2
公开(公告)日：2016-05-31
申请号：US13384234
申请日：2010-07-16
申请人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
发明人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski
摘要： The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
摘要翻译： 本发明涉及改进的微生物抗原疫苗，药物组合物，免疫原性组合物和抗体及其在治疗微生物感染，特别是包括葡萄球菌来源的细菌来源的微生物感染中的用途。 理想地，本发明涉及与其宿主配体结合降低的重组葡萄球菌MSCRAMM或MSCRAMM样蛋白或其片段，用于治疗。
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3.发明申请Use Of Resistin Antisense Oligonucleotides And/Or Sirna Molecules In The Treatment Of Rheumatoid Arthritis 审中-公开抗性反义寡核苷酸和/或Sirna分子在类风湿关节炎治疗中的应用公开(公告)号：US20080039411A1
公开(公告)日：2008-02-14
申请号：US10590635
申请日：2005-02-23
申请人： Ulf Smith , Ivan Nagaev , Maria Bokarewa , Andrej Tarkowski
发明人： Ulf Smith , Ivan Nagaev , Maria Bokarewa , Andrej Tarkowski
IPC分类号： A61K31/7088 , A61P19/02
CPC分类号： C12N15/113 , A61K31/557 , A61K45/06 , A61K2039/505 , C07K16/18 , G01N33/564 , G01N2800/102 , A61K2300/00
摘要： The present invention relates to the use of oligonucleotides antisense to part of the resistin gene and siRNA blocking the action of resistin for the treatment of Rheumatoid Arthritis. The present invention also relates to the determination of the onset of rheumatoid arthritis.
摘要翻译： 本发明涉及反义部分抵抗素基因的寡核苷酸和阻断抗性蛋白作用用于治疗类风湿关节炎的siRNA的用途。 本发明还涉及确定类风湿性关节炎的发病。
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4.发明授权Methods of using gelsolin levels to characterize a subject's risk of developing rheumatoid arthritis 有权使用凝溶胶蛋白水平来表征受试者发展类风湿性关节炎的风险的方法公开(公告)号：US08198094B2
公开(公告)日：2012-06-12
申请号：US12225128
申请日：2007-03-15
申请人： Thomas P. Stossel , Teresia Anna Charlotta Magnuson Osborn , Andrej Tarkowski , Eric Leuchovius, legal representative
IPC分类号： G01N33/00
CPC分类号： A61K38/1709 , A61K45/06 , G01N33/564 , G01N33/6887 , G01N2333/4703 , G01N2333/4712 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/50 , G01N2800/52
摘要： The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
摘要翻译： 本发明涉及使用凝溶胶蛋白来治疗炎症性疾病（例如类风湿性关节炎）和使用凝溶胶蛋白来诊断，监测和评估炎性疾病（例如类风湿性关节炎）的治疗。
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公开(公告)号：US20120208743A1
公开(公告)日：2012-08-16
申请号：US13455878
申请日：2012-04-25
申请人： Thomas P. STOSSEL , Teresia Anna Charlotta Magnuson Osborn , Andrej Tarkowski , Erlc Leuchovius
发明人： Thomas P. STOSSEL , Teresia Anna Charlotta Magnuson Osborn , Andrej Tarkowski , Erlc Leuchovius
CPC分类号： A61K38/1709 , A61K45/06 , G01N33/564 , G01N33/6887 , G01N2333/4703 , G01N2333/4712 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/50 , G01N2800/52
摘要： The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
摘要翻译： 本发明涉及使用凝溶胶蛋白来治疗炎症性疾病（例如类风湿性关节炎）和使用凝溶胶蛋白来诊断，监测和评估炎性疾病（例如类风湿性关节炎）的治疗。
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6.发明申请公开(公告)号：US20100227807A1
公开(公告)日：2010-09-09
申请号：US12225128
申请日：2007-03-15
CPC分类号： A61K38/1709 , A61K45/06 , G01N33/564 , G01N33/6887 , G01N2333/4703 , G01N2333/4712 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/50 , G01N2800/52
摘要： The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
摘要翻译： 本发明涉及使用凝溶胶蛋白来治疗炎症性疾病（例如类风湿性关节炎）和使用凝溶胶蛋白来诊断，监测和评估炎性疾病（例如类风湿性关节炎）的治疗。
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