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公开(公告)号：US06523392B2
公开(公告)日：2003-02-25
申请号：US09768647
申请日：2001-01-24
IPC分类号： G01N2700
CPC分类号： G01Q70/18 , G01N19/10 , G01N2291/0427
摘要： An apparatus and method for sensing chemical and/or biological analytes includes a deflectable arm of a microcantilever formed over and contacting a sensing element. A gaseous or liquid medium which may include the analyte being detected, is introduced to the sensing element. The sensing element undergoes volumetric expansion or contraction in the presence of the analyte sought to be detected, typically by adsorbing the analyte. The volumetric change of the sensing element causes the deflectable arm to deflect. The deflectable arm includes at least one measurable physical property which changes when the arm deflects. Detecting means are provided to measure the change in the physical property to determine the presence and amount of analyte present. An array of microcantilevers in which each microcantilever is dedicated to detecting a particular analyte which may be included in the medium, is also provided.
摘要翻译： 用于感测化学和/或生物分析物的装置和方法包括形成在感测元件上方并接触感测元件的微悬臂梁的可偏转臂。 可以将包括被检测的分析物的气体或液体介质引入感测元件。 通常通过吸附分析物，感测元件在待测物质存在下经历体积膨胀或收缩。 感测元件的体积变化导致可偏转臂偏转。 可偏转臂包括当臂挠曲时改变的至少一个可测量的物理特性。 提供检测手段以测量物理性质的变化以确定存在的分析物的存在和量。 还提供了一组微悬臂梁，其中每个微悬臂梁专用于检测可包括在介质中的特定分析物。
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公开(公告)号：US20100203648A1
公开(公告)日：2010-08-12
申请号：US12523708
申请日：2008-01-18
IPC分类号： G01N33/00
CPC分类号： G01N29/036 , G01N2291/0257 , Y10T436/15 , Y10T436/153333 , Y10T436/16 , Y10T436/17 , Y10T436/172307 , Y10T436/19 , Y10T436/196666 , Y10T436/204998 , Y10T436/205831
摘要： The compositions and methods relate to an organic polymer-inorganic particle sensor material for detecting analytes. Interactions between the polymer and the particles are affected by the presence of analyte, which displaces the polymer and increases its free volume. This change in free volume can be detected, e.g., using an embedded piezoresistive microcantilever (EPM) sensor. Analytes that can be detected include noxious substances, such as hydrogen cyanide gas and carbon monoxide.
摘要翻译： 组合物和方法涉及用于检测分析物的有机聚合物 - 无机颗粒传感器材料。 聚合物和颗粒之间的相互作用受到分析物的存在的影响，分析物取代聚合物并增加其自由体积。 可以检测自由体积的这种变化，例如使用嵌入式压阻微型悬臂梁（EPM）传感器。 可检测的分析物包括有毒物质，如氰化氢气体和一氧化碳。
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公开(公告)号：US20090090168A1
公开(公告)日：2009-04-09
申请号：US12137231
申请日：2008-06-11
IPC分类号： G01N7/00
CPC分类号： G01N7/04 , G01N2203/0023 , G01N2203/0286
摘要： An apparatus and method for sensing chemical and/or biological analytes includes a deflectable arm of a microcantilever at least partially embedded within a sensing element. A gaseous or liquid medium which may include the analyte being detected is introduced to the sensing element. The sensing element undergoes volumetric expansion or contraction in the presence of the analyte sought to be detected, typically by adsorbing the analyte. The volumetric change of the sensing element causes the deflectable arm to deflect. The deflectable arm includes at least one measurable physical property which changes when the arm deflects. Detecting means are provided to measure the change in the physical property to determine the presence and amount of analyte present. An array of microcantilevers in which each microcantilever is dedicated to detecting a particular analyte which may be included in the medium, is also provided.
摘要翻译： 用于感测化学和/或生物分析物的装置和方法包括至少部分地嵌入感测元件内的微悬臂梁的可偏转臂。 可将包括待检测分析物的气体或液体介质引入感测元件。 通常通过吸附分析物，感测元件在待测物质存在下经历体积膨胀或收缩。 感测元件的体积变化导致可偏转臂偏转。 可偏转臂包括当臂挠曲时改变的至少一个可测量的物理特性。 提供检测手段以测量物理性质的变化以确定存在的分析物的存在和量。 还提供了一组微悬臂梁，其中每个微悬臂梁专用于检测可包括在介质中的特定分析物。
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公开(公告)号：US07168294B2
公开(公告)日：2007-01-30
申请号：US11004555
申请日：2004-12-02
IPC分类号： G01N7/00
CPC分类号： G01N29/022 , G01N29/2475 , G01N33/54386 , G01N2291/0427
摘要： An apparatus and method for sensing chemical and/or biological analytes includes a deflectable arm of a microcantilever at least partially embedded within a sensing element. A gaseous or liquid medium which may include the analyte being detected is introduced to the sensing element. The sensing element undergoes volumetric expansion or contraction in the presence of the analyte sought to be detected, typically by adsorbing the analyte. The volumetric change of the sensing element causes the deflectable arm to deflect. The deflectable arm includes at least one measurable physical property which changes when the arm deflects. Detecting means are provided to measure the change in the physical property to determine the presence and amount of analyte present. An array of microcantilevers in which each microcantilever is dedicated to detecting a particular analyte which may be included in the medium, is also provided.
摘要翻译： 用于感测化学和/或生物分析物的装置和方法包括至少部分地嵌入感测元件内的微悬臂梁的可偏转臂。 可将包括待检测分析物的气体或液体介质引入感测元件。 通常通过吸附分析物，感测元件在待测物质存在下经历体积膨胀或收缩。 感测元件的体积变化导致可偏转臂偏转。 可偏转臂包括当臂挠曲时改变的至少一个可测量的物理特性。 提供检测手段以测量物理性质的变化以确定存在的分析物的存在和量。 还提供了一组微悬臂梁，其中每个微悬臂梁专用于检测可包括在介质中的特定分析物。
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公开(公告)号：US07726175B2
公开(公告)日：2010-06-01
申请号：US12137231
申请日：2008-06-11
CPC分类号： G01N7/04 , G01N2203/0023 , G01N2203/0286
摘要： An apparatus and method for sensing chemical and/or biological analytes includes a deflectable arm of a microcantilever at least partially embedded within a sensing element. A gaseous or liquid medium which may include the analyte being detected is introduced to the sensing element. The sensing element undergoes volumetric expansion or contraction in the presence of the analyte sought to be detected, typically by adsorbing the analyte. The volumetric change of the sensing element causes the deflectable arm to deflect. The deflectable arm includes at least one measurable physical property which changes when the arm deflects. Detecting means are provided to measure the change in the physical property to determine the presence and amount of analyte present. An array of microcantilevers in which each microcantilever is dedicated to detecting a particular analyte which may be included in the medium, is also provided.
摘要翻译： 用于感测化学和/或生物分析物的装置和方法包括至少部分地嵌入感测元件内的微悬臂梁的可偏转臂。 可将包括待检测分析物的气体或液体介质引入感测元件。 通常通过吸附分析物，感测元件在待测物质存在下经历体积膨胀或收缩。 感测元件的体积变化导致可偏转臂偏转。 可偏转臂包括当臂挠曲时改变的至少一个可测量的物理特性。 提供检测手段以测量物理性质的变化以确定存在的分析物的存在和量。 还提供了一组微悬臂梁，其中每个微悬臂梁专用于检测可包括在介质中的特定分析物。
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公开(公告)号：US07395693B2
公开(公告)日：2008-07-08
申请号：US11657250
申请日：2007-01-24
IPC分类号： G01N7/04
CPC分类号： G01N7/04 , G01N2203/0023 , G01N2203/0286
摘要： An apparatus and method for sensing chemical and/or biological analytes includes a deflectable arm of a microcantilever at least partially embedded within a sensing element. A gaseous or liquid medium which may include the analyte being detected is introduced to the sensing element. The sensing element undergoes volumetric expansion or contraction in the presence of the analyte sought to be detected, typically by adsorbing the analyte. The volumetric change of the sensing element causes the deflectable arm to deflect. The deflectable arm includes at least one measurable physical property which changes when the arm deflects. Detecting means are provided to measure the change in the physical property to determine the presence and amount of analyte present. An array of microcantilevers in which each microcantilever is dedicated to detecting a particular analyte which may be included in the medium, is also provided.
摘要翻译： 用于感测化学和/或生物分析物的装置和方法包括至少部分地嵌入感测元件内的微悬臂梁的可偏转臂。 可将包括待检测分析物的气体或液体介质引入感测元件。 通常通过吸附分析物，感测元件在待测物质存在下经历体积膨胀或收缩。 感测元件的体积变化导致可偏转臂偏转。 可偏转臂包括当臂挠曲时改变的至少一个可测量的物理特性。 提供检测手段以测量物理性质的变化以确定存在的分析物的存在和量。 还提供了一组微悬臂梁，其中每个微悬臂梁专用于检测可包括在介质中的特定分析物。
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公开(公告)号：US06854317B2
公开(公告)日：2005-02-15
申请号：US10454346
申请日：2003-06-03
IPC分类号： G01B7/16 , B81B3/00 , G01N7/00 , G01N7/18 , G01N27/04 , G01N27/12 , G01N29/02 , G01N33/543 , G01N33/569 , G01N37/00
CPC分类号： G01N29/022 , G01N29/2475 , G01N33/54386 , G01N2291/0427
摘要： An apparatus and method for sensing chemical and/or biological analytes includes a deflectable arm of a microcantilever at least partially embedded within a sensing element. A gaseous or liquid medium which may include the analyte being detected is introduced to the sensing element. The sensing element undergoes volumetric expansion or contraction in the presence of the analyte sought to be detected, typically by adsorbing the analyte. The volumetric change of the sensing element causes the deflectable arm to deflect. The deflectable arm includes at least one measurable physical property which changes when the arm deflects. Detecting means are provided to measure the change in the physical property to determine the presence and amount of analyte present. An array of microcantilevers in which each microcantilever is dedicated to detecting a particular analyte which may be included in the medium, is also provided.
摘要翻译： 用于感测化学和/或生物分析物的装置和方法包括至少部分地嵌入感测元件内的微悬臂梁的可偏转臂。 可将包括待检测分析物的气体或液体介质引入感测元件。 通常通过吸附分析物，感测元件在待测物质存在下经历体积膨胀或收缩。 感测元件的体积变化导致可偏转臂偏转。 可偏转臂包括当臂挠曲时改变的至少一个可测量的物理特性。 提供检测手段以测量物理性质的变化以确定存在的分析物的存在和量。 还提供了一组微悬臂梁，其中每个微悬臂梁专用于检测可包括在介质中的特定分析物。
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公开(公告)号：US06823717B2
公开(公告)日：2004-11-30
申请号：US10454344
申请日：2003-06-03
IPC分类号： G01N700
CPC分类号： G01N29/022 , G01N29/2475 , G01N33/54386 , G01N2291/0427
摘要： An apparatus and method for sensing chemical and/or biological analytes in a gaseous or liquid medium by monitoring the changes in impedance and thickness of a sensing element in the presence of the analyte is provided. Detecting means are provided to measure the change in the physical property of the sensing material to determine the presence and/or the amount of analyte present. An array of hybrid sensors dedicated to detecting a particular analyte which may be included in the medium, is also provided.
摘要翻译： 提供了一种用于通过在存在分析物的情况下监测感测元件的阻抗和厚度的变化来感测气体或液体介质中的化学和/或生物分析物的装置和方法。 提供检测装置以测量感测材料的物理性质的变化，以确定存在的分析物的存在和/或量。 还提供了一组专用于检测可能包含在介质中的特定分析物的混合传感器。
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公开(公告)号：US08828733B2
公开(公告)日：2014-09-09
申请号：US12523708
申请日：2008-01-18
申请人： Timothy L. Porter , Ray Stewart , Timothy L. Vail
发明人： Timothy L. Porter , Ray Stewart , Timothy L. Vail
IPC分类号： G01N27/12 , G01N5/02 , G01N33/00 , G01N29/036
CPC分类号： G01N29/036 , G01N2291/0257 , Y10T436/15 , Y10T436/153333 , Y10T436/16 , Y10T436/17 , Y10T436/172307 , Y10T436/19 , Y10T436/196666 , Y10T436/204998 , Y10T436/205831
摘要： The compositions and methods relate to an organic polymer-inorganic particle sensor material for detecting analytes. Interactions between the polymer and the particles are affected by the presence of analyte, which displaces the polymer and increases its free volume. This change in free volume can be detected, e.g., using an embedded piezoresistive microcantilever (EPM) sensor. Analytes that can be detected include noxious substances, such as hydrogen cyanide gas and carbon monoxide.
摘要翻译： 组合物和方法涉及用于检测分析物的有机聚合物 - 无机颗粒传感器材料。 聚合物和颗粒之间的相互作用受到分析物的存在的影响，分析物取代聚合物并增加其自由体积。 可以检测自由体积的这种变化，例如使用嵌入式压阻微型悬臂梁（EPM）传感器。 可检测的分析物包括有毒物质，如氰化氢气体和一氧化碳。
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