公开(公告)号：US08334505B2

公开(公告)日：2012-12-18

申请号：US12026799

申请日：2008-02-06

申请人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

发明人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC分类号： H01J49/26

CPC分类号： G01N27/62 ,  G01N33/497 ,  H01J49/105 ,  Y10T436/24

摘要： A system and methods are described for generating reagent ions and product ions for use in a mass spectrometry system. Applications for the system and method are also disclosed for detecting volatile organic compounds in trace concentrations. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass and peak intensity values for ion species during spectrometry and faults within the system.

摘要翻译： 描述了用于产生用于质谱系统的试剂离子和产物离子的系统和方法。 还公开了用于检测痕量浓度的挥发性有机化合物的系统和方法的应用。 微波或高频RF能源将试剂蒸气的颗粒电离以形成试剂离子。 试剂离子进入诸如漂移室的室以与流体样品相互作用。 电场引导试剂离子并促进与流体样品的相互作用以形成产物离子。 然后试剂离子和产物离子在电场的影响下离开室，由质谱模块检测。 该系统包括用于设置系统参数值和分析模块的各种控制模块，用于在光谱测定和系统内的故障期间检测离子物质的质量和峰值强度值。

公开(公告)号：US20120003748A1

公开(公告)日：2012-01-05

申请号：US12026799

申请日：2008-02-06

申请人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

发明人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC分类号： G01N33/00

CPC分类号： G01N27/62 ,  G01N33/497 ,  H01J49/105 ,  Y10T436/24

摘要： A system and methods are described for generating reagent ions and product ions for use in a mass spectrometry system. Applications for the system and method are also disclosed for detecting volatile organic compounds in trace concentrations. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass and peak intensity values for ion species during spectrometry and faults within the system.

摘要翻译： 描述了用于产生用于质谱系统的试剂离子和产物离子的系统和方法。 还公开了用于检测痕量浓度的挥发性有机化合物的系统和方法的应用。 微波或高频RF能源将试剂蒸气的颗粒电离以形成试剂离子。 试剂离子进入诸如漂移室的室以与流体样品相互作用。 电场引导试剂离子并促进与流体样品的相互作用以形成产物离子。 然后试剂离子和产物离子在电场的影响下离开室，由质谱模块检测。 该系统包括用于设置系统参数值和分析模块的各种控制模块，用于在光谱测定和系统内的故障期间检测离子种类的质量和峰值强度值。

公开(公告)号：US20090095901A1

公开(公告)日：2009-04-16

申请号：US11869978

申请日：2007-10-10

申请人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

发明人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC分类号： H01J49/26

CPC分类号： H01J49/145

摘要： A system and methods are described for generating reagent ions and product ions for use in a quadrupole mass spectrometry system. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a quadrupole mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass values for ion species during spectrometry and faults within the system.

摘要翻译： 描述了用于产生用于四极质谱系统的试剂离子和产物离子的系统和方法。 微波或高频RF能源将试剂蒸气的颗粒电离以形成试剂离子。 试剂离子进入诸如漂移室的室以与流体样品相互作用。 电场引导试剂离子并促进与流体样品的相互作用以形成产物离子。 然后试剂离子和产物离子在电场的影响下离开室，由四极质谱仪模块进行检测。 该系统包括各种控制模块，用于设置系统参数值和分析模块，用于在光谱测定和系统内故障时检测离子物质的质量值。

公开(公告)号：US08003936B2

公开(公告)日：2011-08-23

申请号：US11869980

申请日：2007-10-10

申请人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

发明人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC分类号： H01J49/26

CPC分类号： H01J49/145

摘要： A system, components thereof, and methods are described for time-of-flight mass spectrometry. A microwave or high-frequency RF energy source is used to ionize a reagent vapor to form reagent ions. The reagent ions enter a chamber and interact with a fluid sample to form product ions. The reagent ions and product ions are directed to a time-of-flight mass spectrometer module for detection and determination of a mass value for the ions. The time-of-flight mass spectrometer module can include an optical system and an ion beam adjuster for focusing, interrupting, or altering a flow of reagent and product ions according to a specified pattern. The time-of-flight mass spectrometer module can include signal processing techniques to collect and analyze an acquired signal, for example, using statistical signal processing, such as maximum likelihood signal processing.

摘要翻译： 描述了用于飞行时间质谱的系统及其组件和方法。 微波或高频RF能量源用于电离试剂蒸气以形成试剂离子。 试剂离子进入室并与流体样品相互作用以形成产物离子。 试剂离子和产物离子被引导到飞行时间质谱仪模块，用于检测和确定离子的质量值。 飞行时间质谱模块可以包括用于根据指定图案聚焦，中断或改变试剂和产物离子流的光学系统和离子束调节器。 飞行时间质谱仪模块可以包括用于收集和分析所获取的信号的信号处理技术，例如使用诸如最大似然信号处理的统计信号处理。

公开(公告)号：US08003935B2

公开(公告)日：2011-08-23

申请号：US11869978

申请日：2007-10-10

申请人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

发明人： Timothy Roger Robinson ,  Mark Attwood ,  Xing Chen ,  William M. Holber ,  Mark Philip Longson ,  Jonathan Henry Palk ,  Ali Shajii ,  John A. Smith

IPC分类号： H01J49/26

CPC分类号： H01J49/145

摘要： A system and methods are described for generating reagent ions and product ions for use in a quadruple mass spectrometry system. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a quadruple mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass values for ion species during spectrometry and faults within the system.

摘要翻译： 描述了用于产生用于四重质谱系统的试剂离子和产物离子的系统和方法。 微波或高频RF能源将试剂蒸气的颗粒电离以形成试剂离子。 试剂离子进入诸如漂移室的室以与流体样品相互作用。 电场引导试剂离子并促进与流体样品的相互作用以形成产物离子。 然后试剂离子和产物离子在电场的影响下离开室，由四重质谱仪模块进行检测。 该系统包括各种控制模块，用于设置系统参数值和分析模块，用于在光谱测定和系统内故障时检测离子物质的质量值。