公开(公告)号：US07247634B2

公开(公告)日：2007-07-24

申请号：US11034195

申请日：2005-01-12

Applicant: Zhenkun Ma ,  Yafei Jin ,  Jing Li ,  Charles Z. Ding ,  Keith P. Minor ,  Jamie C. Longgood ,  In Ho Kim ,  Susan Harran ,  Keith Combrink ,  Timothy W. Morris

Inventor： Zhenkun Ma ,  Yafei Jin ,  Jing Li ,  Charles Z. Ding ,  Keith P. Minor ,  Jamie C. Longgood ,  In Ho Kim ,  Susan Harran ,  Keith Combrink ,  Timothy W. Morris

IPC: C07D498/08 ,  A61K31/395 ,  A61P31/04

CPC classification number: C07D498/00

Abstract: Rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms are claimed in this invention. The inventive rifamycin derivatives are uniquely designed in that they have a rifamycin moiety covalently linked to a linker group through the C-3 carbon of the rifamycin moiety and the linker is, in turn covalently linked to a therapeutic moiety or antibacterial agent/pharmacophore. The therapeutic moiety can be a quinolone, an oxazolidinone, a macrolide, an aminoglycoside, a tetracycline core or a structure/pharmacophore associated with an antibacterial agent.

Abstract translation: 本发明要求具有抗微生物活性的利福霉素衍生物，包括抗药性微生物的活性。 本发明的利福霉素衍生物是唯一设计的，因为它们具有通过利福霉素部分的C-3碳与连接基共价连接的利福霉素部分，接头又与治疗部分或抗菌剂/药效基团共价连接。 治疗部分可以是喹诺酮，恶唑烷酮，大环内酯，氨基糖苷，四环素核心或与抗菌剂相关的结构/药效团。

公开(公告)号：US4738397A

公开(公告)日：1988-04-19

申请号：US903991

申请日：1986-09-05

Applicant: Timothy W. Morris

Inventor： Timothy W. Morris

IPC: A01M7/00 ,  B05B15/68 ,  B05B15/08

CPC classification number: B05B15/08 ,  A01M7/006

Abstract: A support arm device for use in supporting a spray head in spraying liquids. The device comprises an elongated support portion having a longitudinal axis, and an elongated mounting portion attached at a point between its ends to one end of the support portion. The mounting portion has a longitudinal axis transverse to the axis of the support portion and at least one end of the mounting portion includes fastner. The device further includes an elongated leg portion attached to the other end of the support portion and having a longitudinal axis transverse to the axis of the support portion. A releasable clamp is about the leg portion, the clamp for securing a spray head into the device.

Abstract translation: 一种用于支撑喷头以喷洒液体的支撑臂装置。 该装置包括具有纵向轴线的细长支撑部分，以及细长的安装部分，其连接在其端部之间的点到支撑部分的一端。 安装部分具有横向于支撑部分的轴线的纵向轴线，并且安装部分的至少一个端部包括紧固件。 该装置还包括连接到支撑部分的另一端并且具有横向于支撑部分的轴线的纵向轴线的细长腿部分。 可释放的夹具围绕脚部，夹具用于将喷头固定到装置中。