公开(公告)号：US20240208979A1

公开(公告)日：2024-06-27

申请号：US18287612

申请日：2022-04-19

申请人： Tisento Therapeutics Inc.

发明人： Lei Jia ,  Ara Mermerian ,  Timothy Claude Barden ,  Thomas Wai-Ho Lee ,  Karthik Iyer ,  Glen Robert Rennie ,  Rajesh R. Iyengar ,  Joon Jung ,  Paul Allan Renhowe

IPC分类号： C07D487/04 ,  A61K31/506

CPC分类号： C07D487/04 ,  A61K31/506

摘要： The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. In some embodiments, the compounds are those of Table I or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240207265A1

公开(公告)日：2024-06-27

申请号：US18287616

申请日：2022-04-19

申请人： Tisento Therapeutics Inc.

发明人： Lei Jia ,  Ara Mermerian ,  Timothy Claude Barden ,  Thomas Wai-Ho Lee ,  Karthik Iyer ,  Glen Robert Rennie ,  Rajesh R. Iyengar ,  Joon Jung ,  Paul Allan Renhowe ,  Susana dos Santos Correia ,  Peter Germano

IPC分类号： A61K31/506 ,  A61P25/28

CPC分类号： A61K31/506 ,  A61P25/28

摘要： The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3′,5′-monophosphate (cGMP) or both, or an upregulation of the NO-sGC-cGMP pathway is desirable. Compounds useful in the methods of the invention are those of Formula (I) or pharmaceutically acceptable salts thereof.

公开(公告)号：US11897887B2

公开(公告)日：2024-02-13

申请号：US16955494

申请日：2018-12-19

申请人： Tisento Therapeutics Inc.

发明人： Glen Robert Rennie ,  Paul Allan Renhowe ,  Takashi Nakai ,  Ara Mermerian ,  Helen Cumberbatch

IPC分类号： C07D487/04 ,  C07F9/09 ,  A61K45/06

CPC分类号： C07D487/04 ,  C07F9/09 ,  A61K45/06

摘要： The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts, pharmaceutical formulations comprising them as well as their phosphate ester prodrugs, and their uses alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or the upregulation of the NO pathway is desirable. The compounds are of Formula I.