公开(公告)号：US20240166674A1

公开(公告)日：2024-05-23

申请号：US17768354

申请日：2020-10-13

申请人： FUJIFILM WAKO PURE CHEMICAL CORPORATION

发明人： Seiho KIKUCHI ,  Kimihiko SANO

IPC分类号： C07F9/6524 ,  C07F9/09 ,  C07F9/165

CPC分类号： C07F9/6524 ,  C07F9/09 ,  C07F9/165

摘要： The present invention has an object to provide a phosphoramidite activator that improves a solubility of 5-benzylthio-1H-tetrazole in acetonitrile and does not reduce the yield and a purity of a target product.
The present invention relates to a phosphoramidite activator containing (i) at least one compound that is selected from the group consisting of piperidine, pyrrolidine, N-alkylpiperidine, and N-alkylpyrrolidine, (ii) 5-benzylthio-1H-tetrazole, and (iii) acetonitrile; and a method for activating a phosphoramidite and a method for synthesizing a phosphate ester or a thiophosphate ester, both methods using the activator.

公开(公告)号：US11945830B2

公开(公告)日：2024-04-02

申请号：US17679746

申请日：2022-02-24

申请人： Enanta Pharmaceuticals, Inc.

发明人： Adam Szymaniak ,  Jianming Yu ,  Kevin McGrath ,  Xiben Li ,  Tyler J. Mann ,  Robert Leon ,  In Jong Kim ,  Yat Sun Or ,  Long Nguyen

IPC分类号： C07F9/09 ,  A61K31/14 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61K31/519 ,  A61K45/06 ,  C07D491/048 ,  C07D519/00

CPC分类号： C07F9/09 ,  A61K45/06 ,  C07D491/048 ,  C07D519/00

摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US11897887B2

公开(公告)日：2024-02-13

申请号：US16955494

申请日：2018-12-19

申请人： Tisento Therapeutics Inc.

发明人： Glen Robert Rennie ,  Paul Allan Renhowe ,  Takashi Nakai ,  Ara Mermerian ,  Helen Cumberbatch

IPC分类号： C07D487/04 ,  C07F9/09 ,  A61K45/06

CPC分类号： C07D487/04 ,  C07F9/09 ,  A61K45/06

摘要： The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts, pharmaceutical formulations comprising them as well as their phosphate ester prodrugs, and their uses alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or the upregulation of the NO pathway is desirable. The compounds are of Formula I.

公开(公告)号：US20240002553A1

公开(公告)日：2024-01-04

申请号：US18029520

申请日：2021-09-30

申请人： THE CHEMOURS COMPANY FC, LLC

发明人： PHAN LINH TANG ,  MICHAEL DEEMER ,  VINCENT FRANCO ,  STEVEN FURYK ,  STEPHEN JAMES GETTY ,  DIPTI DILIP KHASNIS ,  XIAOLIN LIU ,  ALEXANDER ANTHONY MARCHIONE ,  ANDRII MATSNEV ,  BENJAMIN WEAVER MESSMORE ,  PETER A. MORKEN ,  CAMERON PARRISH ,  ADAM PAUL SMITH ,  EDWARD PATRICK CAREY

IPC分类号： C08F14/22 ,  C08F14/28 ,  C08F14/26 ,  C07C317/22 ,  C07C317/14 ,  C07F9/09 ,  C07C309/31

CPC分类号： C08F14/22 ,  C08F14/28 ,  C08F14/26 ,  C07C317/22 ,  C07C317/14 ,  C07F9/09 ,  C07C309/31

摘要： A process for polymerizing at least one fluoromonomer in an aqueous medium containing initiator and hydrocarbon dispersing agent to form an aqueous dispersion of particles of fluoropolymer. The hydrocarbon dispersing agent comprises a compound of formula I:


R—(XZ)n  I

wherein R is a hydrophobic hydrocarbon moiety that comprises one or more saturated or unsaturated, non-cyclic or cyclic aliphatic groups, the percentage of total CH3 groups in relation to the total of CH3, CH2 and CH groups in said one or more aliphatic groups being at least about 70%, said hydrophobic moiety being free of siloxane units; wherein each X may be the same or different and represents an ionic hydrophilic moiety; wherein each Z may be a same or different and represents one or more counter ions for said ionic hydrophilic moiety; and wherein n is 1 to 3.

公开(公告)号：US11857646B2

公开(公告)日：2024-01-02

申请号：US17325173

申请日：2021-05-19

申请人： Lantheus Medical Imaging, Inc.

发明人： Simon P. Robinson ,  Robert W. Siegler ,  Nhung Tuyet Nguyen ,  David C. Onthank ,  Tarakeshwar Vishwanath Anklekar ,  Charles Chester Van Kirk

IPC分类号： A61K49/22 ,  A61B8/08 ,  C07F9/09 ,  C07F9/10

CPC分类号： A61K49/223 ,  A61B8/481 ,  A61K49/226 ,  A61K49/227 ,  C07F9/09 ,  C07F9/106

摘要： Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.

公开(公告)号：US20180344752A1

公开(公告)日：2018-12-06

申请号：US16058778

申请日：2018-08-08

申请人： Metabasis Therapeutics, Inc.

发明人： Mark Erion ,  Hongjian Jiang ,  Serge Henri Boyer

IPC分类号： A61K31/661 ,  A61K45/06 ,  C07F9/09 ,  C07F9/40

CPC分类号： A61K31/661 ,  A61K45/06 ,  C07F9/09 ,  C07F9/092 ,  C07F9/40 ,  C07F9/4006

摘要： A thyroid hormone receptor agonist and its use in the treatment of a disease associated thyroid hormone receptor beta are described. The compound can be effective in lowering cholesterol with minimum or no adverse effects on the heart or thyroid hormone axis.

公开(公告)号：US10035791B2

公开(公告)日：2018-07-31

申请号：US15287725

申请日：2016-10-06

申请人： China Medical University

发明人： Kuo-Hsiung Lee ,  Yu Zhao ,  Sheng-Chu Kuo ,  Chung-Y. Hsu ,  Woei-Cherng Shyu ,  Yu-Chian Chen ,  Chen-Huan Lin ,  Wei Lee ,  Chun-Wei Chiang ,  Chang-Hai Tsai

IPC分类号： C07D221/02 ,  C07D407/12 ,  C07D311/94 ,  C07D221/04

CPC分类号： C07D407/12 ,  C07D221/04 ,  C07D311/94 ,  C07D405/12 ,  C07F9/09

摘要： The present disclosure relates to a bicyclic compound, a pharmaceutical composition thereof, and its novel use. More particularly, the present disclosure relates to the bicyclic compound according to Formula I or Formula II, the pharmaceutical composition for treating a stroke, and the use of the bicyclic compound treating the stroke.

公开(公告)号：US20180201751A1

公开(公告)日：2018-07-19

申请号：US15743437

申请日：2016-10-17

申请人： LG CHEM, LTD.

发明人： Seokwon KIM ,  Se Hyun KIM ,  Tae Hyung KIM ,  Pyeong-Gi KIM ,  Suk Jo CHOI ,  Dong Hyun CHO

IPC分类号： C08K3/016 ,  C08K3/04 ,  C08K5/521 ,  C08K7/02 ,  C01B32/168 ,  C08L101/00 ,  C08K3/40

CPC分类号： C08K3/016 ,  C01B32/168 ,  C01B2202/02 ,  C01B2202/06 ,  C01B2202/26 ,  C01B2202/34 ,  C01B2202/36 ,  C01B2204/26 ,  C01B2204/32 ,  C07F9/09 ,  C07F9/12 ,  C08J5/042 ,  C08J5/043 ,  C08J5/047 ,  C08K3/04 ,  C08K3/045 ,  C08K3/40 ,  C08K5/521 ,  C08K7/02 ,  C08L101/00

摘要： The present invention relates to a carbon composite material and a method for producing the same, and more particularly, to a carbon composite material capable of improving electrostatic dispersibility and flame retardancy, and a method for producing the same. The carbon composite material according to the present invention can be effectively applied to products requiring conductivity and flame retardancy.

公开(公告)号：US09949991B2

公开(公告)日：2018-04-24

申请号：US15034543

申请日：2014-11-06

申请人： Aeromics, Inc.

发明人： Marc F. Pelletier ,  Paul Robert McGuirk ,  George William Farr ,  Steven Williams

IPC分类号： A61K31/661 ,  A61K31/167 ,  C07F9/09 ,  A61K9/00 ,  A61K47/18 ,  A61K31/222 ,  A61K31/5375

CPC分类号： A61K31/661 ,  A61K9/0019 ,  A61K31/167 ,  A61K31/222 ,  A61K31/5375 ,  A61K47/18 ,  A61K47/186 ,  C07F9/09

摘要： The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., glioblastoma and ovarian hyperstimulation syndrome. The invention provides, inter alia, methods of treating or controlling a disease condition mediated by an aquaporin, e.g., diseases or conditions of water imbalance and other diseases.

公开(公告)号：US09873710B2

公开(公告)日：2018-01-23

申请号：US15339041

申请日：2016-10-31

申请人： Health Innovation Ventures B.V.

发明人： Jeffrey Bruce Smaill ,  Adam Vorn Patterson ,  Amir Ashoorzadeh ,  Christopher Paul Guise ,  Alexandra Marie Mowday ,  David Francis Ackerley ,  Elsie May Williams ,  Janine Naomi Copp

IPC分类号： C07F9/09 ,  C07C255/58 ,  C07C309/66 ,  C07C317/48 ,  C07D295/13 ,  C07D295/192 ,  C07C309/69 ,  C07C317/36 ,  C07D295/104

CPC分类号： C07F9/09 ,  C07C255/58 ,  C07C309/66 ,  C07C309/69 ,  C07C317/36 ,  C07C317/48 ,  C07D295/104 ,  C07D295/13 ,  C07D295/192 ,  C07F9/091

摘要： The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.