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    Formulations of 5-fluorocytosine and uses thereof
    1.
    发明授权
    Formulations of 5-fluorocytosine and uses thereof 有权

    公开(公告)号：US10449194B2

    公开(公告)日：2019-10-22

    申请号：US15891243

    申请日：2018-02-07

    申请人： Tocagen Inc.

    发明人： Harry E. Gruber ,  Douglas J. Jolly ,  Kay Olmstead

    IPC分类号： A61K31/513 ,  A61K9/20 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/505 ,  A61K31/7048 ,  A61K38/51 ,  A61K9/00 ,  A61K38/50

    摘要： The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorouracil in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.

    FORMULATIONS OF 5-FLUOROCYTOSINE AND USES THEREOF
    2.
    发明申请
    FORMULATIONS OF 5-FLUOROCYTOSINE AND USES THEREOF 审中-公开

    公开(公告)号：US20200281929A1

    公开(公告)日：2020-09-10

    申请号：US16654318

    申请日：2019-10-16

    申请人： Tocagen Inc.

    发明人： Harry E. Gruber ,  Douglas J. Jolly ,  Kay Olmstead

    IPC分类号： A61K31/513 ,  A61K9/20 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/505 ,  A61K31/7048 ,  A61K38/51 ,  A61K9/00 ,  A61K38/50

    摘要： The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorourcail in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.

    FORMULATIONS OF 5-FLUOROCYTOSINE AND USES THEREOF
    5.
    发明申请
    FORMULATIONS OF 5-FLUOROCYTOSINE AND USES THEREOF 有权
    5-氟代异喹啉的配方及其用途

    公开(公告)号：US20160235751A1

    公开(公告)日：2016-08-18

    申请号：US15136056

    申请日：2016-04-22

    申请人： Tocagen Inc.

    发明人： Harry E. Gruber ,  Douglas J. Jolly ,  Kay Olmstead

    IPC分类号： A61K31/513 ,  A61K38/50 ,  A61K9/20 ,  A61K9/00

    CPC分类号： A61K31/513 ,  A61K9/0053 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/505 ,  A61K31/7048 ,  A61K38/50 ,  A61K38/51 ,  C12Y305/04001 ,  A61K2300/00

    摘要： The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorourcail in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.

    摘要翻译： 本公开提供5-氟胞嘧啶的延长释放制剂。 另一方面，提供了一种治疗真菌病的方法。 该方法包括向有需要的受试者施用真菌治疗有效量的包含5-氟胞嘧啶的组合物。 另一方面，提供了治疗癌症的方法。 该方法包括向有需要的受试者施用足够量的表达载体以诱导能够将5-氟胞嘧啶转化成癌症细胞中的5-氟尿嘧啶的胞嘧啶脱氨酶的表达和癌症治疗有效量的组合物 包含5-氟胞嘧啶。