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公开(公告)号：US20190352667A1
公开(公告)日：2019-11-21
申请号：US16431626
申请日：2019-06-04
申请人： Tocagen Inc.
发明人： Douglas J. Jolly , Carlos Ibanez
IPC分类号： C12N15/86
摘要： The disclosure provide cell lines and methods for the production of vectors and viral particles useful in gene therapy.
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公开(公告)号：US20180087035A1
公开(公告)日：2018-03-29
申请号：US15672029
申请日：2017-08-08
申请人： Tocagen Inc.
CPC分类号： C12N7/00 , A61K31/513 , A61K38/2292 , A61K48/00 , C12N9/78 , C12N15/86 , C12N2740/13043 , C12N2760/16021 , C12N2760/16032 , C12N2760/16043
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
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公开(公告)号：US09642921B2
公开(公告)日：2017-05-09
申请号：US14137803
申请日：2013-12-20
申请人： Tocagen Inc.
IPC分类号： A01N63/00 , A61K48/00 , A61K31/495 , A61K31/513 , A61K38/50 , A61K35/768
CPC分类号： A61K48/0058 , A61K31/495 , A61K31/513 , A61K35/768 , A61K38/50 , C12N2740/13032 , C12Y305/04001 , A61K2300/00
摘要： This disclosure relates to a combination therapy of chemotherapeutics and/or radiosensitizing agents with a replication competent viral vectors for treating cell proliferative disorders and chemotherapeutic treatments. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.
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公开(公告)号：US20200239858A1
公开(公告)日：2020-07-30
申请号：US16560525
申请日：2019-09-04
申请人： Tocagen Inc.
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
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公开(公告)号：US10035983B2
公开(公告)日：2018-07-31
申请号：US14274556
申请日：2014-05-09
申请人： Tocagen Inc.
IPC分类号： C12N7/00 , C07K14/55 , C07K14/57 , C07K16/28 , C12N9/10 , C12N9/78 , C12N15/113 , C12N15/86 , A61K39/00
CPC分类号： C12N7/00 , A61K2039/505 , C07K14/55 , C07K14/57 , C07K16/2818 , C07K2317/622 , C07K2319/00 , C12N9/1077 , C12N9/78 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2740/13043 , C12N2840/102 , C12N2840/203 , C12Y305/04001
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
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公开(公告)号：US09889133B2
公开(公告)日：2018-02-13
申请号：US15136056
申请日：2016-04-22
申请人： Tocagen Inc.
发明人： Harry E. Gruber , Douglas J. Jolly , Kay Olmstead
IPC分类号： A61K9/20 , A61K31/496 , A61K31/513 , A61K31/4196 , A61K31/505 , A61K31/7048 , A61K38/51 , A61K9/00 , A61K38/50
CPC分类号： A61K31/513 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/4196 , A61K31/496 , A61K31/505 , A61K31/7048 , A61K38/50 , A61K38/51 , C12Y305/04001 , A61K2300/00
摘要： The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorourcail in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.
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公开(公告)号：US20150273029A1
公开(公告)日：2015-10-01
申请号：US14438564
申请日：2013-10-24
申请人： Tocagen Inc.
IPC分类号： A61K38/50 , A61K48/00 , A61K45/06 , C12N15/86 , A61K31/513
CPC分类号： A61K38/50 , A61K31/513 , A61K35/768 , A61K45/06 , A61K48/00 , C12N15/86 , C12N2740/10042 , C12N2740/10045 , C12N2740/13032 , C12N2740/13043 , C12N2830/00 , C12N2830/60 , C12Y305/04001
摘要： This disclosure provides a retroviral replicating vector for gene delivery comprising a therapeutic cassette containing at least one mini-promoter linked to a gene to be expressed.
摘要翻译： 本公开提供了用于基因递送的逆转录病毒复制载体，其包含含有至少一个与待表达基因连锁的微启动子的治疗盒。
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公开(公告)号：US10407666B2
公开(公告)日：2019-09-10
申请号：US15672029
申请日：2017-08-08
申请人： Tocagen Inc.
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
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公开(公告)号：US20190015414A1
公开(公告)日：2019-01-17
申请号：US15891243
申请日：2018-02-07
申请人： Tocagen Inc.
发明人： Harry E. Gruber , Douglas J. Jolly , Kay Olmstead
IPC分类号： A61K31/513 , A61K9/20 , A61K38/50 , A61K9/00 , A61K31/4196 , A61K31/496 , A61K31/505 , A61K31/7048 , A61K38/51
CPC分类号： A61K31/513 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/4196 , A61K31/496 , A61K31/505 , A61K31/7048 , A61K38/50 , A61K38/51 , C12Y305/04001 , A61K2300/00
摘要： The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorouracil in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.
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公开(公告)号：US20170175137A1
公开(公告)日：2017-06-22
申请号：US15127388
申请日：2015-03-25
申请人： Tocagen Inc.
IPC分类号： C12N15/86 , A61K31/7088 , A61K38/21 , A61K38/20 , A61K48/00 , C12N15/113
CPC分类号： C12N15/86 , A61K31/7088 , A61K35/76 , A61K38/2013 , A61K38/217 , A61K48/005 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/31 , C12N2330/51 , C12N2740/13043
摘要： The disclosure provides vectors for treating cancers, method of producing such vectors and methods of use of the vectors.
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