公开(公告)号：US5783124A

公开(公告)日：1998-07-21

申请号：US730599

申请日：1996-10-15

申请人： Tohru Uenishi ,  Isamu Yamamoto ,  Kazutake Okamoto ,  Hideo Sato ,  Yasuhiro Shiota ,  Hidehiko Sakurai ,  Seiji Watanuki ,  Mitsuru Suzuki

发明人： Tohru Uenishi ,  Isamu Yamamoto ,  Kazutake Okamoto ,  Hideo Sato ,  Yasuhiro Shiota ,  Hidehiko Sakurai ,  Seiji Watanuki ,  Mitsuru Suzuki

IPC分类号： B01D69/08 ,  B01D71/16 ,  B01D33/21

CPC分类号： B01D71/16 ,  B01D69/08

摘要： A cellulose acetate membrane composed of a mixture comprising a cellulose triacetate and a cellulose diacetate and having an improved heat stability, which does not substantially show a melting peak of cellulose diacetate but substantially shows a melting peak of cellulose triacetate, in a differential thermal analysis. By mixing a cellulose triacetate and a cellulose diacetate at an appropriate ratio, crystallization or orientational crystallization of each component due to a high pressure stream sterilization can be avoided and a cellulose acetate membrane with improved water permeability and sieving coefficient of myoglobin after a high pressure steam sterilization can be obtained.

摘要翻译： 一种醋酸纤维素膜，由包含三乙酸纤维素和二乙酸纤维素并具有改进的热稳定性的混合物组成，其在差热分析中基本上不显示纤维素二乙酸酯的熔融峰，但基本上显示出三乙酸纤维素的熔融峰。 通过以适当的比例混合三乙酸纤维素和二乙酸纤维素，可以避免由于高压流灭菌而导致的每种组分的结晶或取向结晶，以及在高压蒸汽之后具有改善的透水性和肌红蛋白的筛分系数的乙酸纤维素膜 可以获得灭菌。

公开(公告)号：US5624561A

公开(公告)日：1997-04-29

申请号：US272397

申请日：1994-07-26

申请人： Tohru Uenishi ,  Isamu Yamamoto ,  Kazutake Okamoto ,  Hideo Sato ,  Yasuhiro Shiota ,  Hidehiko Sakurai ,  Seiji Watanuki ,  Mitsuru Suzuki

发明人： Tohru Uenishi ,  Isamu Yamamoto ,  Kazutake Okamoto ,  Hideo Sato ,  Yasuhiro Shiota ,  Hidehiko Sakurai ,  Seiji Watanuki ,  Mitsuru Suzuki

IPC分类号： B01D69/08 ,  B01D71/16 ,  B01D39/00

CPC分类号： B01D71/16 ,  B01D69/08

摘要： A cellulose acetate membrane composed of a mixture comprising a cellulose triacetate and a cellulose diacetate and having an improved heat stability, which does not substantially show a melting peak of cellulose diacetate but substantially shows a melting peak of cellulose triacetate, in a differential thermal analysis. By mixing a cellulose triacetate and a cellulose diacetate at an appropriate ratio, crystallization or orientational crystallization of each component due to a high pressure steam sterilization can be avoided and a cellulose acetate membrane with improved water permeability and sieving coefficient of myoglobin after a high pressure steam sterilization can be obtained.

摘要翻译： 一种醋酸纤维素膜，由包含三乙酸纤维素和二乙酸纤维素并具有改进的热稳定性的混合物组成，其在差热分析中基本上不显示纤维素二乙酸酯的熔融峰，但基本上显示出三乙酸纤维素的熔融峰。 通过以适当的比例混合三乙酸纤维素和二乙酸纤维素，可以避免由于高压蒸汽灭菌而引起的每种组分的结晶或取向结晶，以及在高压蒸汽之后具有改善的透水性和肌红蛋白筛分系数的乙酸纤维素膜 可以获得灭菌。

公开(公告)号：US08840788B2

公开(公告)日：2014-09-23

申请号：US13147721

申请日：2010-02-02

申请人： Makoto Ohno ,  Isamu Yamamoto ,  Takahito Sagara ,  Kimihiro Mabuchi ,  Tohru Uenishi ,  Shinya Koyama

发明人： Makoto Ohno ,  Isamu Yamamoto ,  Takahito Sagara ,  Kimihiro Mabuchi ,  Tohru Uenishi ,  Shinya Koyama

IPC分类号： B01D69/08 ,  B01D63/02 ,  B01D71/68 ,  A61M1/16

CPC分类号： B01D69/087 ,  A61M1/1621 ,  B01D63/02 ,  B01D71/68 ,  B01D2313/04

摘要： The present invention provides a hollow fiber membrane where the membrane strength and pressure resistance to pressurization from the dialysate side is ensured, the retaining rate of water permeability after the repeated pressure load from outside is high, the resistance to the pressure from outside is excellent and the assembling property into module (low leakage rate at the adhered part) is satisfactory at the same time. The present invention also provides a method for manufacturing the same, and a blood purification module.

摘要翻译： 本发明提供了一种中空纤维膜，其中确保了来自透析液一侧的膜强度和耐压性，在来自外部的反复压力负载之后的透水性保持率高，对外部的压力的耐受性优异， 模块的组装性（粘附部分的低泄漏率）同时是令人满意的。 本发明还提供了其制造方法和血液净化模块。

公开(公告)号：US20110290709A1

公开(公告)日：2011-12-01

申请号：US13147721

申请日：2010-02-02

申请人： Makoto Ohno ,  Isamu Yamamoto ,  Takahito Sagara ,  Kimihiro Mabuchi ,  Tohru Uenishi ,  Shinya Koyama

发明人： Makoto Ohno ,  Isamu Yamamoto ,  Takahito Sagara ,  Kimihiro Mabuchi ,  Tohru Uenishi ,  Shinya Koyama

IPC分类号： B01D71/68 ,  B01D69/08 ,  D01D5/06 ,  B01D63/02

CPC分类号： B01D69/087 ,  A61M1/1621 ,  B01D63/02 ,  B01D71/68 ,  B01D2313/04

摘要： The present invention provides a hollow fiber membrane where the membrane strength and pressure resistance to pressurization from the dialysate side is ensured, the retaining rate of water permeability after the repeated pressure load from outside is high, the resistance to the pressure from outside is excellent and the assembling property into module (low leakage rate at the adhered part) is satisfactory at the same time. The present invention also provides a method for manufacturing the same, and a blood purification module.An annealing spinning method was found where a spinning dope is discharged from a nozzle into a coagulation bath, an appropriate elongation is applied so as to enhance the membrane strength, an elongation is continued during a water-washing step so as not to relax the elongation, and no elongation is applied during drying whereby the strain is relaxed. By the annealing spinning, a hollow fiber membrane and a blood purification module can be obtained where although the water permeability is low, the efficiency is high, no risk of backfiltration is resulted, the pressure resistance and strength are enhanced due to elongation, the stability is enhanced due to annealing during drying, the safety and assembling property into module are excellent.

摘要翻译： 本发明提供了一种中空纤维膜，其中确保了来自透析液一侧的膜强度和耐压性，在来自外部的反复压力负载之后的透水性保持率高，对外部的压力的耐受性优异， 模块的组装性（粘附部分的低泄漏率）同时是令人满意的。 本发明还提供了其制造方法和血液净化模块。 发现退火纺丝法，其中纺丝原液从喷嘴排出到凝固浴中，施加适当的伸长率以提高膜强度，在水洗步骤期间持续延伸以便不使伸长率松弛 ，并且在干燥期间不施加伸长率，从而使应变松弛。 通过退火纺丝，可以获得中空纤维膜和血液净化组件，其中透水性低，效率高，不会产生反渗透的风险，耐压性和强度由于伸长而提高，稳定性 由于干燥过程中的退火而增强，模块的安全性和组装性优异。