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    Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains
    1.
    发明申请
    Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains 失效
    使用N-结合型糖链诊断胰腺癌的方法

    公开(公告)号：US20110065141A1

    公开(公告)日：2011-03-17

    申请号：US12991340

    申请日：2009-05-08

    申请人： Tokuzo Arao ,  Kazuko Matsumoto ,  Kazuto Nishio ,  Hiroki Sakamoto ,  Masayuki Kitano ,  Masatoshi Kudo

    发明人： Tokuzo Arao ,  Kazuko Matsumoto ,  Kazuto Nishio ,  Hiroki Sakamoto ,  Masayuki Kitano ,  Masatoshi Kudo

    IPC分类号： C12Q1/37 ,  C12Q1/34

    CPC分类号： G01N33/57438 ,  Y10T436/24

    摘要： The present invention is to provide a novel marker for diagnosing pancreatic cancer, a method for determining if a subject has pancreatic cancer utilizing the marker, etc. The present inventors collected blood from patients of 78 cases in total including patients of 24 cases with pancreaticobiliary-duct benign disorder (16 gallstone cases and 8 pancreatitis cases) and patients of 54 cases with pancreatic cancer, and mass spectrometry was performed on N-linked sugar chains in plasma. From the 74 mass-spectrometric peaks detected, 65 sugar chains were extracted based on the results of PAM analysis. These extracted sugar chains were then used to predict pancreatic cancer or pancreaticobiliary-duct benign disorder, to correctly diagnose 74% cases. Further, a T-test was performed between the two groups, the group of pancreaticobiliary-duct benign disorder and the group of pancreatic cancer, which identified two sugar chains, the sugar chain of m/z 3031 and the sugar chain of m/z 2362, as sugar chains demonstrating significant difference (p

    摘要翻译： 本发明提供一种用于诊断胰腺癌的新型标记物，用于确定受试者是否使用标记物的胰腺癌的方法等。本发明人从78例患者中收集了总共包括24例胰腺胆管癌患者的血液， 膀胱良性疾病（16例胆囊病例和8例胰腺炎病例）和54例胰腺癌患者，并对血浆中的N链糖链进行质谱分析。 根据PAM分析结果，从检测到的74个质谱峰中提取出65个糖链。 然后将这些提取的糖链用于预测胰腺癌或胰胆管良性疾病，以正确诊断74％的病例。 此外，在两组之间进行T检验，即胰胆管良性病变组和胰腺癌组，鉴定了两条糖链，m / z 3031的糖链和m / z的糖链 2362，由于糖链显示出显着性差异（p <0.05），并且两组之间的表达水平呈现2倍或更大的差异。 使用这些糖链的正确检测率用六个分类器计算，所有这些分类器都得到约70％的正确检测结果。