公开(公告)号：US20040161383A1

公开(公告)日：2004-08-19

申请号：US10746327

申请日：2003-12-23

申请人： Tokyo Gas Company Limited

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata ,  Asuka Ito

IPC分类号： A61K051/00

CPC分类号： C07K7/06 ,  A61K49/1815 ,  A61K51/1206 ,  C07K5/06026 ,  C07K5/06078 ,  C07K5/06095 ,  C12Q1/37 ,  Y02P20/55

摘要： A diagnostic agent for pancreatic exocrine function comprising an amino acid or a peptide containing at least one 13C or 14C atom, or a pharmaceutically acceptable salt thereof other than Bz-Tyr-13C-PABA is provided. A 13C- or 14C-labeled compound represented by the following formula (II):X2nullR2nullY2nullZ1nullnull(II)or a salt thereof, wherein X2 is a hydrogen atom or a protecting group, R2 is a peptide of 2 to 5 amino acids, an amino acid or a single bond, Y2 is an amino acid, Z1 is an amino acid optionally having a protecting group, and at least one of the amino acids in R2, Y2 and Z1, or at least one of the protecting groups in X2 and Z1 when the protecting groups contain a carbon atom, is 13C or 14C-labeled.

摘要翻译： 提供了包含含有至少一个13 C或14 C原子的氨基酸或肽的胰外分泌功能的诊断剂或其除Bz-Tyr-CABAA以外的药学上可接受的盐。 由下式（II）表示的C 13或C 14标记化合物：X 2 -R 2 -Y 2 -Z 1（II）或其盐，其中X 2为氢原子或保护基，R 2 是2至5个氨基酸的肽，氨基酸或单键，Y2是氨基酸，Z1是任选具有保护基团的氨基酸，并且R2，Y2和Z1中的至少一个氨基酸， 或当保护基含有碳原子时，X 2和Z 1中的至少一个保护基团是13 C或14 C标记的。