公开(公告)号：US3954776A

公开(公告)日：1976-05-04

申请号：US499948

申请日：1974-08-23

申请人： Tomio Muro ,  Sogo Fukuzawa ,  Yasuaki Chihara ,  Tohru Nakao ,  Kiyoshi Ogawa

发明人： Tomio Muro ,  Sogo Fukuzawa ,  Yasuaki Chihara ,  Tohru Nakao ,  Kiyoshi Ogawa

IPC分类号： C07D295/092 ,  C07D211/14

CPC分类号： C07D295/088 ,  Y10S514/818 ,  Y10S514/821

摘要： 1-[Methylated piperidino (and pyrrolidin-1-yl)]-3-(substituted phenoxy)-2-propanols of the formula: ##SPC1##Wherein R is a 2-thienylmethyl group, a 2-pyridylmethyl group, a 2-pyridyl group, a tetrahydrofurfuryloxy group, a furfuryloxy group, a 2-thienylmethoxy group, a 2-pyridyloxy group or a group of the formula R.sup.5 --X--A--O-- wherein R.sup.5 is a lower alkyl group, X is --O--, --S-- or --SO.sub.2 --, and A is a lower alkylene group or a --CH.sub.2 --C.ident.C--CH.sub.2 -- group, R.sup.1 is a hydrogen atom, a lower alkyl group or a halogen atom, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom or a methyl group, and n is zero or 1, and pharmaceutically acceptable acid addition and quarternary ammonium salts thereof are disclosed. They exhibit antiarrhythmic action, local anaesthetic action, analgesic action and gastric juice secretion inhibiting action.

摘要翻译： 1- [甲基化哌啶子基（和吡咯烷-1-基）] - 3-（取代的苯氧基）-2-丙醇，其具有下式：

公开(公告)号：US4005084A

公开(公告)日：1977-01-25

申请号：US594913

申请日：1975-07-10

申请人： Tomio Muro ,  Yasuaki Chihara ,  Sogo Fukuzawa ,  Kiyoshi Ogawa ,  Akira Nakanishi

发明人： Tomio Muro ,  Yasuaki Chihara ,  Sogo Fukuzawa ,  Kiyoshi Ogawa ,  Akira Nakanishi

IPC分类号： C07D333/16 ,  C07D413/12

CPC分类号： C07D333/16 ,  Y10S514/927

摘要： Morpholine compounds of the formula: ##STR1##wherein each of R.sup.1 and R.sup.2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and pharmaceutically acceptable acid addition salts thereof, have strong inhibitory activities on peptic ulcer, gastric motility and gastric secretion but have very weak acetylcholine antagonistic activity.

摘要翻译： 下式的吗啉化合物：其中R 1和R 2各自为氢原子或具有1至4个碳原子的烷基及其药学上可接受的酸加成盐，对消化性溃疡，胃动力和胃部具有很强的抑制活性 分泌却具有非常弱的乙酰胆碱拮抗作用。