公开(公告)号：US5011824A

公开(公告)日：1991-04-30

申请号：US436058

申请日：1989-11-13

申请人： Tomoaki Masada ,  Yasuhiko Ueno ,  Eiji Hayakawa ,  Hirotake Naganuma ,  Mitsuru Terajima ,  Tokuyuki Kuroda ,  Katsuichi Shuto ,  Shunji Ichikawa

发明人： Tomoaki Masada ,  Yasuhiko Ueno ,  Eiji Hayakawa ,  Hirotake Naganuma ,  Mitsuru Terajima ,  Tokuyuki Kuroda ,  Katsuichi Shuto ,  Shunji Ichikawa

IPC分类号： A61K9/02 ,  A61K38/22

CPC分类号： A61K9/02 ,  A61K38/2214

摘要： A motilin preparation in the form of a rectal suppository containing motilin together with a pH controller capable of adjusting the pH value of the intrarectal fluid to 8.0 to 10.0, which is highly useful as a rectal suppository.

公开(公告)号：US06254889B1

公开(公告)日：2001-07-03

申请号：US08809651

申请日：1997-03-26

申请人： Makoto Kigoshi ,  Tomoaki Masada ,  Yasuhiko Ueno ,  Yasuhiro Ishikawa ,  Eiji Hayakawa

发明人： Makoto Kigoshi ,  Tomoaki Masada ,  Yasuhiko Ueno ,  Yasuhiro Ishikawa ,  Eiji Hayakawa

IPC分类号： A61K910

CPC分类号： C07D473/06 ,  A61K9/146 ,  C07D473/04

摘要： The present invention relates to a solid dispersion and a solid dispersion dosage form which comprise a xanthine derivative represented by the following formula (I) or a pharmacologically allowable salt thereof and a polymer. (In the above formula, R1 and R2 are the same or different, and represent substituted or unsubstituted lower alkyl groups, and Q represents a hydrogen atom or a hydroxyl group.)

摘要翻译： 本发明涉及一种固体分散体和固体分散体剂型，其包含由下式（I）表示的黄嘌呤衍生物或其药理学允许的盐和聚合物（在上式中，R 1和R 2相同或不同， 不同，表示取代或未取代的低级烷基，Q表示氢原子或羟基。

公开(公告)号：US5700492A

公开(公告)日：1997-12-23

申请号：US332533

申请日：1994-10-31

申请人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Yoshika Sanada ,  Teiichi Miwa ,  Tomoaki Masada

发明人： Kiyoshi Morimoto ,  Yasushi Watanabe ,  Yoshika Sanada ,  Teiichi Miwa ,  Tomoaki Masada

IPC分类号： A61J3/10 ,  B30B11/08 ,  B30B15/00 ,  B28B21/00

CPC分类号： B30B15/0011 ,  Y10S264/37

摘要： A rotary-type tabletting machine with lubricant spraying means, wherein a turn table has plural penetrated holes comprising dies provided at fixed intervals in a ring-like arrangement, each hole is provided with a pair of punches above and under the hole, each pair of punches is rotated together with the turn table and execute piston operation so that tablets are continuously produced by compressing pharmaceutical material filled in the die. The rotary-type tabletting machine is provided with a spraying chamber with an upper open end for inserting an upper punch and enclosing the die when the turn table moves to a rotation position which is after a rotation position where a molded table is discharged and before a rotation position where pharmaceutical material is filled in the die. A spray connected with the spraying chamber sprays lubricant in the spraying chamber, and pulsating air generating means connected with the spraying chamber diffuses. The lubricant sprayed in the spraying chamber.

摘要翻译： 一种具有润滑剂喷射装置的旋转式压片机，其特征在于，转台具有多个穿孔，所述多个贯穿孔包括以环状布置的固定间隔设置的模具，每个孔在所述孔的上方和下方设置有一对冲孔， 冲头与转台一起旋转并执行活塞操作，使得通过压缩填充在模具中的药物材料来连续生产片剂。 旋转式压片机设置有喷雾室，其具有用于插入上冲头的上开口端，并且当转台移动到在模制台排出的旋转位置之后的旋转位置并且在 模具中填充药物的旋转位置。 与喷雾室连接的喷雾器在喷雾室中喷射润滑剂，并且与喷射室连接的脉动空气发生装置扩散。 润滑剂喷洒在喷雾室中。

公开(公告)号：US5565212A

公开(公告)日：1996-10-15

申请号：US405458

申请日：1995-03-16

申请人： Yorozu Yokomori ,  Toshikazu Murayama ,  Tomoaki Masada ,  Motohiro Ohta ,  Masaki Azuma ,  Yoshio Yumiba

发明人： Yorozu Yokomori ,  Toshikazu Murayama ,  Tomoaki Masada ,  Motohiro Ohta ,  Masaki Azuma ,  Yoshio Yumiba

IPC分类号： A23K1/16 ,  A23K1/00 ,  A23K1/18 ,  A61K9/28 ,  A61K9/50

CPC分类号： A61K9/5036 ,  A23K40/35 ,  A61K9/501 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047

摘要： Disclosed is a process for producing a composition for ruminants, which is characterized in that a nucleus containing a physiologically active substance is coated with a coating material prepared by suspending in water (i) an emulsion comprising water and at least one hydrophobic substance hardly soluble in water and (ii) a slurry containing at least one polymer soluble in water of pH 5.0 or below and insoluble in water of pH over 5.0 In the process, an aqueous suspension is used for coating instead of a meterial dissolved in an organic solvent.

摘要翻译： 本发明公开了一种反刍动物用组合物的制造方法，其特征在于，含有生理活性物质的细胞核涂覆有通过在水中悬浮而制备的涂料（i）包含水和至少一种难溶于 水和（ii）含有至少一种可溶于pH 5.0或以下的水的聚合物并且不溶于pH超过5.0的水的浆料。在该方法中，使用水性悬浮液代替溶解在有机溶剂中的水溶液。