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47 条记录 (耗时 0.039 秒)

    Method for stabilizing duocarmycin derivatives
    3.
    发明授权
    Method for stabilizing duocarmycin derivatives 失效
    稳定杜卡霉素衍生物的方法

    公开(公告)号：US5703080A

    公开(公告)日：1997-12-30

    申请号：US737145

    申请日：1996-10-30

    申请人： Masashi Nakakura ,  Yuji Ueno ,  Eiji Hayakawa ,  Tokuyuki Kuroda

    发明人： Masashi Nakakura ,  Yuji Ueno ,  Eiji Hayakawa ,  Tokuyuki Kuroda

    IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K9/19 ,  A61K31/495 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61P35/00 ,  C07D241/04

    CPC分类号： A61K9/19 ,  A61K31/495 ,  A61K47/02 ,  A61K47/26 ,  A61K9/0019

    摘要： Stabilized duocarmycin derivatives represented by formula (I): ##STR1## wherein R is lower alkyl, allyl or benzyl, and X is Cl or Br, are prepared by adding at least a compound selected from the group consisting of a saccharide, an electrolyte, a water-soluble polymer, a polyhydric alcohol and a surfactant to a solution containing the duocarmycin derivatives. Also provided are freeze-dried pharmaceutical preparations containing the stabilized duocarmycin derivatives.

    摘要翻译： PCT No.PCT / JP95 / 00962 Sec。 371日期1996年10月30日 102（e）日期1996年10月30日PCT提交1995年5月19日PCT公布。 公开号WO95 / 31971 日期：1995年11月30日由式（I）表示的稳定化的二焦虑霉素衍生物：其中R是低级烷基，烯丙基或苄基，X是Cl或Br，通过加入至少一种选自 来自由糖类，电解质，水溶性聚合物，多元醇和表面活性剂组成的组，与含有二焦耳霉素衍生物的溶液。 还提供了含有稳定的二焦耳霉素衍生物的冷冻干燥的药物制剂。

    Lithographic printing plate precursor
    5.
    发明授权
    Lithographic printing plate precursor 有权
    平版印刷版前体

    公开(公告)号：US08835099B2

    公开(公告)日：2014-09-16

    申请号：US13322922

    申请日：2010-05-31

    申请人： Yasushi Miyamoto ,  Yasuhiro Asawa ,  Maru Aburano ,  Eiji Hayakawa ,  Satoko Kumazumi

    发明人： Yasushi Miyamoto ,  Yasuhiro Asawa ,  Maru Aburano ,  Eiji Hayakawa ,  Satoko Kumazumi

    IPC分类号： B41M5/00 ,  B41N1/00 ,  G03F7/00 ,  G03F7/26 ,  G03F7/11 ,  B41C1/10

    CPC分类号： G03F7/11 ,  B41C1/1008 ,  B41C1/1016 ,  B41C2201/04 ,  B41C2210/02 ,  B41C2210/04 ,  B41C2210/06 ,  B41C2210/14 ,  B41C2210/22 ,  B41C2210/24 ,  B41C2210/266

    摘要： The present invention provides a lithographic printing plate precursor which exhibits satisfactory ink cleanup and restart toning characteristics during printing.Disclosed is a lithographic printing plate precursor comprising a substrate having thereon in order an interlayer containing a copolymer comprising K units and L units, and an image-forming layer, wherein said K unit is derived from a monomer of the formula I: wherein R1 represents a hydrogen atom, a C1-22 linear, branched or cyclic alkyl group, a C1-22 linear, branched or cyclic, substituted alkyl group, a C6-24 aryl group or substituted aryl group, wherein the substituent is selected from a C1-4alkyl group, an aryl group, a halogen atom, a keto group, an ester group, an alkoxy group, or a cyano group; Y represent a single bond, or a C1-22 linear, branched or cyclic alkylene; or CH2═CHPO(OH)2; and said L unit is derived from a monomer of the formula II: CH2═CRCONH2  (II) wherein R is H or CH3, and said K units are present from more than 3% and less than 40% and said L units are present from more than 60% and less than 97% in the copolymer.

    摘要翻译： 本发明提供一种平版印刷版原版，其在印刷过程中表现出令人满意的油墨净化和重新启动调色特性。 公开了一种平版印刷版原版，其包含基板，其上具有包含含有K个单元和L个单元的共聚物的中间层和图像形成层，其中所述K单元衍生自式I的单体：其中R1表示 氢原子，C1-22直链，支链或环状烷基，C1-22直链，支链或环状取代的烷基，C6-24芳基或取代的芳基，其中取代基选自C1- 4-烷基，芳基，卤素原子，酮基，酯基，烷氧基或氰基; Y表示单键或C1-22直链，支链或环状亚烷基; 或CH 2 = CHPO（OH）2; 并且所述L单元衍生自式II的单体：CH 2 = CRCONH 2（II）其中R是H或CH 3，并且所述K个单元存在于大于3％且小于40％的范围内，并且所述L单元存在于 在共聚物中超过60％且小于97％。

    Photosensitive planographic printing plate
    7.
    发明授权
    Photosensitive planographic printing plate 有权
    感光平版印刷版

    公开(公告)号：US07883830B2

    公开(公告)日：2011-02-08

    申请号：US11817876

    申请日：2006-03-15

    申请人： Koji Hayashi ,  Eiji Hayakawa

    发明人： Koji Hayashi ,  Eiji Hayakawa

    IPC分类号： G03F7/00 ,  G03F7/26

    CPC分类号： G03F7/11 ,  B41C1/1016 ,  B41C2201/02 ,  B41C2201/04 ,  B41C2210/04 ,  B41C2210/06 ,  B41C2210/22 ,  B41C2210/24 ,  G03F7/0752

    摘要： A photosensitive planographic printing plate comprising a substrate and a photosensitive layer including a photopolymerizable compound, wherein the photosensitive layer and the substrate are provided between them with an undercoat layer including a (co)polymer having structural units having ethylenically unsaturated groups bonded with silicon atoms and phosphonic acid groups.

    摘要翻译： 一种光敏平版印刷版，其特征在于，具有基材和含有光聚合性化合物的感光层，其中，所述感光层与所述基材之间设置有包含具有与硅原子键合的烯键式不饱和基团的结构单元的（共）聚合物的底涂层， 膦酸基团。

    INTRABUCCALLY RAPIDLY DISINTEGRATING TABLET AND A PRODUCTION METHOD OF THE TABLETS
    10.
    发明申请
    INTRABUCCALLY RAPIDLY DISINTEGRATING TABLET AND A PRODUCTION METHOD OF THE TABLETS 有权
    快速消毒片和片剂的生产方法

    公开(公告)号：US20120135076A1

    公开(公告)日：2012-05-31

    申请号：US13282271

    申请日：2011-10-26

    申请人： Motohiro OHTA ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

    发明人： Motohiro OHTA ,  Eiji Hayakawa ,  Kunio Ito ,  Sanji Tokuno ,  Kiyoshi Morimoto ,  Yasushi Watanabe

    IPC分类号： A61K9/20 ,  B02C23/00

    CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

    摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

    摘要翻译： 通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。 通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于 通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。