公开(公告)号：US20120149598A1

公开(公告)日：2012-06-14

申请号：US13145014

申请日：2010-01-22

申请人： Tomoyuki Inoue ,  Fumihiko Takamatsu ,  Naoyuki Maeda ,  Kohji Nishida ,  Yasuo Tano

发明人： Tomoyuki Inoue ,  Fumihiko Takamatsu ,  Naoyuki Maeda ,  Kohji Nishida ,  Yasuo Tano

IPC分类号： C40B30/06 ,  C12Q1/02 ,  C12N5/10

CPC分类号： C12N5/0621 ,  C12N2500/25 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2502/99 ,  C12N2510/04 ,  C12N2533/54 ,  C12Q1/6897

摘要： The present invention provides a feeder cell for target cell induction, wherein the feeder cell is transduced with an immortalizing gene and a suicide gene; and a production process for a target cell sheet using the feeder cell for target cell induction.

摘要翻译： 本发明提供用于靶细胞诱导的饲养细胞，其中所述饲养细胞用永生化基因和自杀基因转导; 以及使用用于靶细胞诱导的饲养细胞的靶细胞片的制备方法。

公开(公告)号：US20080183242A1

公开(公告)日：2008-07-31

申请号：US11698948

申请日：2007-01-29

申请人： Yasuo Tano ,  Hirokazu Sakaguchi ,  Hugo Quiroz Mercado ,  Eiji Yonezawa ,  Hiroyuki Kanda

发明人： Yasuo Tano ,  Hirokazu Sakaguchi ,  Hugo Quiroz Mercado ,  Eiji Yonezawa ,  Hiroyuki Kanda

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： A method for improving visual ability of even a patient's non-operative eye is provided. The electrical stimulation method for improving vision of patient's eyes comprises placing an electrode in one of patient's right and left eyes, and outputting an electrical stimulation pulse signal from the electrode placed in the patient's eye under a predetermined stimulation condition to stimulate cells constituting a retina or optic nerve, thereby improving vision of the other patient's eye with no electrode being placed.

摘要翻译： 提供了一种提高患者非手术眼睛视力的方法。 用于改善患者眼睛视力的电刺激方法包括将电极放置在患者的右眼和左眼之一中，并且在预定的刺激条件下从放置在患者眼睛中的电极输出电刺激脉冲信号，以刺激构成视网膜的细胞或 视神经，从而改善没有放置电极的其他患者眼睛的视力。

公开(公告)号：US20070027502A1

公开(公告)日：2007-02-01

申请号：US11492987

申请日：2006-07-26

申请人： Yasuo Tano ,  Takashi Fujikado

发明人： Yasuo Tano ,  Takashi Fujikado

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： A visual restoration aiding device for restoring vision of a patient, comprises: a signal generation unit including a substrate to be placed on an outer side of a choroid of a patient's eye and a plurality of electrodes arranged on the substrate for applying electrical stimulation pulse signals to cells constituting a retina; a photographing unit which photographs an object to be recognized by the patient; and a processing unit which converts image data obtained by the photographing unit to data for electrical stimulation pulse signal and transmits the converted data to the signal generation unit: wherein, based on the data for electrical stimulation pulse signal transmitted from the processing unit, the signal generation unit forms a waveform of an electrical stimulation pulse signal to be outputted from each electrode into a biphasic rectangular wave including rectangular waves of opposite polarities, and sets a pulse width of the electrical stimulation pulse signal to 0.2 msec. or more and 2 msec. or less.

摘要翻译： 一种用于恢复患者视力的视觉恢复辅助装置，包括：信号产生单元，包括放置在患者眼睛脉络膜外侧的基底和布置在基底上的多个电极，用于施加电刺激脉冲信号 构成视网膜的细胞; 拍摄单元，其拍摄患者要识别的对象; 以及处理单元，其将由拍摄单元获取的图像数据转换为电刺激脉冲信号的数据，并将转换的数据发送到信号生成单元：其中，基于从处理单元发送的电刺激脉冲信号的数据， 生成单元形成从每个电极输出的电刺激脉冲信号的波形为包括相反极性的矩形波的双相矩形波，并将电刺激脉冲信号的脉冲宽度设置为0.2毫秒。 或更多和2毫秒。 或更少。

公开(公告)号：US5300063A

公开(公告)日：1994-04-05

申请号：US879386

申请日：1992-05-07

申请人： Yasuo Tano ,  Masanori Enomoto ,  Yasuo Ota

发明人： Yasuo Tano ,  Masanori Enomoto ,  Yasuo Ota

IPC分类号： A61B18/20 ,  A61F9/011 ,  A61B17/32

CPC分类号： A61F9/00821 ,  A61B2018/2025 ,  A61F2009/00863

摘要： An ophthalmic laser apparatus has a proper exit angle from a probe to prevent a sclera from being damaged when the probe is used to treat an eye of a patient. A laser beam emitted from a laser oscillator is directed to a light cable receptacle connector by an optical system. The laser beam is directed to a delivery optical system or a probe by a light cable having a connecting part at one end thereof to be connected to the light cable receptacle connector. The probe is bent near an end thereof and the end of the probe is generally spherically shaped.

摘要翻译： 眼科激光设备具有与探针适当的出射角，以防止当探针用于治疗患者眼睛时的巩膜受损。 从激光振荡器发射的激光束通过光学系统被引导到光缆插座连接器。 激光束通过具有在其一端的连接部分的光缆被引导到输送光学系统或探针，以连接到光缆插座连接器。 探针在其一端附近弯曲，并且探针的端部通常为球形。

公开(公告)号：US08090447B2

公开(公告)日：2012-01-03

申请号：US11492987

申请日：2006-07-26

申请人： Yasuo Tano ,  Takashi Fujikado

发明人： Yasuo Tano ,  Takashi Fujikado

IPC分类号： A61N1/18

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： A visual restoration aiding device for restoring vision of a patient, comprises: a signal generation unit including a substrate to be placed on an outer side of a choroid of a patient's eye and a plurality of electrodes arranged on the substrate for applying electrical stimulation pulse signals to cells constituting a retina; a photographing unit which photographs an object to be recognized by the patient; and a processing unit which converts image data obtained by the photographing unit to data for electrical stimulation pulse signal and transmits the converted data to the signal generation unit: wherein, based on the data for electrical stimulation pulse signal transmitted from the processing unit, the signal generation unit forms a waveform of an electrical stimulation pulse signal to be outputted from each electrode into a biphasic rectangular wave including rectangular waves of opposite polarities, and sets a pulse width of the electrical stimulation pulse signal to 0.2 msec. or more and 2 msec. or less.

摘要翻译： 一种用于恢复患者视力的视觉恢复辅助装置，包括：信号产生单元，包括放置在患者眼睛脉络膜外侧的基底和布置在基底上的多个电极，用于施加电刺激脉冲信号 构成视网膜的细胞; 拍摄单元，其拍摄患者要识别的对象; 以及处理单元，其将由拍摄单元获取的图像数据转换为电刺激脉冲信号的数据，并将转换的数据发送到信号生成单元：其中，基于从处理单元发送的电刺激脉冲信号的数据， 生成单元形成从每个电极输出的电刺激脉冲信号的波形为包括相反极性的矩形波的双相矩形波，并将电刺激脉冲信号的脉冲宽度设置为0.2毫秒。 或更多和2毫秒。 或更少。

公开(公告)号：US07706886B2

公开(公告)日：2010-04-27

申请号：US11333242

申请日：2006-01-18

申请人： Takeshi Morimoto ,  Tomomitsu Miyoshi ,  Takashi Fujikado ,  Yasuo Tano ,  Yutaka Fukuda

发明人： Takeshi Morimoto ,  Tomomitsu Miyoshi ,  Takashi Fujikado ,  Yasuo Tano ,  Yutaka Fukuda

IPC分类号： A61N1/36

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： An ophthalmic treatment method for inhibiting death of retinal constitutive cells of an eye by stimulating the cells includes a first step of placing a positive electrode and a negative electrode in such positions outside the eye that the electrodes provide electrical stimulation to the cells, at least one of the electrodes being placed on one of a cornea and sclera of the eye; and a second step of generating an electrical stimulation pulse having an electric current set at 20 μA or more but not exceeding 300 μA from each placed electrode.

摘要翻译： 通过刺激细胞来抑制眼睛的视网膜组成型细胞死亡的眼科治疗方法包括将正电极和负极放置在眼外的这些位置的电极的第一步骤，电极向细胞提供电刺激，至少一个 的电极放置在眼睛的角膜和巩膜中的一个上; 以及第二步骤，从每个放置的电极产生电刺激脉冲，其电流设定在20μA以上但不超过300μA。

公开(公告)号：US20060058857A1

公开(公告)日：2006-03-16

申请号：US10537266

申请日：2003-12-04

申请人： Yasuo Tano ,  Takashi Fujikado ,  Yutaka Fukuda ,  Tetsuya Yagi

发明人： Yasuo Tano ,  Takashi Fujikado ,  Yutaka Fukuda ,  Tetsuya Yagi

IPC分类号： A61N1/18

CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/0543 ,  A61N1/37229 ,  A61N1/3727

摘要： An object is to provide an artificial vision system ensuring a wide field of view without damaging a retina. In the artificial vision system, a plurality of electrodes (23) are to be implanted so as to stick in an optic papilla of an eye of a patient. A signal for stimulation pulse is generated based on an image captured by an image pick up device (11) to be disposed outside a body of the patient. The electrical stimulation signals outputted from the electrodes (23) based on the signals for stimulation pulse stimulate an optic nerve of the eye, thereby enabling the patient to visually recognize the image from the image pickup device (11).

摘要翻译： 目的是提供一种人造视觉系统，确保广泛的视野，而不损害视网膜。 在人造视觉系统中，要植入多个电极（23）以便粘贴在患者眼睛的视神经乳头中。 基于由图像拾取装置（11）捕获的图像来生成用于刺激脉冲的信号，以设置在患者身体外部。 基于用于刺激脉冲的信号从电极（23）输出的电刺激信号刺激眼睛的视神经，从而使得患者能够从图像拾取装置（11）可视地识别图像。

公开(公告)号：US5562691A

公开(公告)日：1996-10-08

申请号：US267364

申请日：1994-06-29

申请人： Yasuo Tano ,  Kiyoshi Makihara

发明人： Yasuo Tano ,  Kiyoshi Makihara

IPC分类号： A61B17/00 ,  A61F9/007 ,  A61B17/32

CPC分类号： A61F9/00763 ,  A61B2017/00544 ,  A61F9/00754

摘要： An ophthalmic surgical apparatus for vitreous surgery in the eyeball comprises a probe provided with a guide knife, having an end portion formed in a predetermined curve, and a dissecting knife movable along the curve of the guide knife to dissect proliferated membrane, moving device that moves the dissecting knife so as to reciprocate between an initial position and the end portion of the guide knife.

摘要翻译： 一种用于眼球玻璃体手术的眼科手术装置包括具有导向刀的探针，其具有以预定曲线形成的端部，以及可沿着导向刀的曲线移动以解剖增殖膜的解剖刀，移动装置移动 所述解剖刀在所述引导刀的初始位置与所述端部之间往复运动。

公开(公告)号：US08265764B2

公开(公告)日：2012-09-11

申请号：US10537266

申请日：2003-12-04

申请人： Yasuo Tano ,  Takashi Fujikado ,  Yutaka Fukuda ,  Tetsuya Yagi

发明人： Yasuo Tano ,  Takashi Fujikado ,  Yutaka Fukuda ,  Tetsuya Yagi

IPC分类号： A61N1/00 ,  A61B5/04

CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/0543 ,  A61N1/37229 ,  A61N1/3727

摘要： An object is to provide an artificial vision system ensuring a wide field of view without damaging a retina. In the artificial vision system, a plurality of electrodes (23) are to be implanted so as to stick in an optic papilla of an eye of a patient. A signal for stimulation pulse is generated based on an image captured by an image pick up device (11) to be disposed outside a body of the patient. The electrical stimulation signals outputted from the electrodes (23) based on the signals for stimulation pulse stimulate an optic nerve of the eye, thereby enabling the patient to visually recognize the image from the image pickup device (11).

摘要翻译： 目的是提供一种人造视觉系统，确保广泛的视野，而不损害视网膜。 在人造视觉系统中，要植入多个电极（23）以便粘贴在患者眼睛的视神经乳头中。 基于由图像拾取装置（11）捕获的图像来生成用于刺激脉冲的信号，以设置在患者身体外部。 基于用于刺激脉冲的信号从电极（23）输出的电刺激信号刺激眼睛的视神经，从而使得患者能够从图像拾取装置（11）可视地识别图像。

公开(公告)号：US07974699B2

公开(公告)日：2011-07-05

申请号：US11727155

申请日：2007-03-23

申请人： Yasuo Tano ,  Hirokazu Sakaguchi ,  Eiji Yonezawa ,  Hiroyuki Kanda

发明人： Yasuo Tano ,  Hirokazu Sakaguchi ,  Eiji Yonezawa ,  Hiroyuki Kanda

IPC分类号： A61N1/36

CPC分类号： A61N1/36046

摘要： A vision regeneration assisting device for regenerating vision of a patient, comprising: a plurality of electrodes which are stuck and placed into an optic disc of the patient; a storage unit which stores a generation position of a phosphene specific to the patient in association with the first output conditions for the stimulation signal that has caused to generate the phosphene, the storage unit storing various first output conditions for the stimulation signals and the generation positions of the phosphenes caused by the stimulation signals based on the various first output conditions in association with each other; a processor which sets second output conditions for the stimulation signal based on image data obtained by an external photography unit and the generation positions of the phosphenes stored in the storage unit, and converts the obtained image data into data for the stimulation signal based on the set second output conditions.

摘要翻译： 一种用于再生患者视力的视觉再生辅助装置，包括：多个电极，其被卡住并放置在患者的视盘中; 存储单元，其与针对已经产生磷光体的刺激信号的第一输出条件相关联地存储与患者特异的磷光体的产生位置，所述存储单元存储用于刺激信号和生成位置的各种第一输出条件 基于相互关联的各种第一输出条件由刺激信号引起的磷光体; 处理器，其基于由外部摄影单元获得的图像数据和存储在存储单元中的磷光体的生成位置，为刺激信号设定第二输出条件，并且将获得的图像数据转换为基于该组的刺激信号的数据 第二个输出条件。