公开(公告)号：US08067001B2

公开(公告)日：2011-11-29

申请号：US12822732

申请日：2010-06-24

申请人： Tong Zhou ,  Kimishisa Ichikawa ,  Robert P. Kimberly ,  William J. Koopman

发明人： Tong Zhou ,  Kimishisa Ichikawa ,  Robert P. Kimberly ,  William J. Koopman

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/30

CPC分类号： A61K39/39558 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/6863

摘要： An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.

摘要翻译： 本发明的抗体与人DR5相互作用以在受体下游产生激动或拮抗作用，包括抑制细胞增殖和细胞凋亡。 已经阐明了抗DR5抗体的核酸序列和氨基酸序列，并且已经产生含有和表达这些序列的载体和细胞。 具体涉及抗体的方法和用途，包括治疗凋亡相关疾病和治疗失调的细胞生长。