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    Human fas gene promoter region
    4.
    发明授权
    Human fas gene promoter region 失效
    人类fas基因启动子区

    公开(公告)号：US5888764A

    公开(公告)日：1999-03-30

    申请号：US377522

    申请日：1995-01-20

    申请人： John D. Mountz ,  Changdan Liu ,  Jianhua Cheng ,  William J. Koopman ,  Tong Zhou

    发明人： John D. Mountz ,  Changdan Liu ,  Jianhua Cheng ,  William J. Koopman ,  Tong Zhou

    IPC分类号： A01K67/027 ,  A61K38/00 ,  C07K14/715 ,  C12N1/21 ,  C12N15/12 ,  C12N15/67 ,  C12Q1/68 ,  C12N5/10 ,  C12N15/11 ,  C12P21/00

    CPC分类号： A01K67/0275 ,  C07K14/715 ,  C12N15/67 ,  A01K2217/05 ,  A61K38/00 ,  C12N2799/022 ,  C12N2799/027

    摘要： Disclosed is a 5' flanking sequence of the human fas gene containing a promoter region. This sequence also contains at least three transcription initiation sites, as well as consensus sequences for AP-1, GF-1, NY-Y, CP-2, EB20, and c-myb. Also disclosed are methods of altering senescence of the immune system by modifying Fas activity in cells to increase or decrease apoptosis. Fas expression and function on T cells from old (22-26-month-old) mice is also compared to young (2-month-old) mice and old CD2-fas transgenic mice. Fas expression and ligand-induced apoptosis was decreased on T cells from old mice compared to young mice. In 26-month-old CD2-fas transgenic mice, Fas and CD44 expression, Fas-induced apoptosis, T cell proliferation and cytokine production were comparable to that of the young mice. These results suggest that T cell senescence with age is associated with defective apoptosis and that the CD2-fas transgene allows the maintenance of Fas apoptosis function and T cell function in aged mice comparable to that of young mice.

    摘要翻译： 披露了含有启动子区的人fas基因的5'侧翼序列。 该序列还含有至少三个转录起始位点，以及AP-1，GF-1，NY-Y，CP-2，EB20和c-myb的共有序列。 还公开了通过改变细胞中的Fas活性来增加或减少凋亡来改变免疫系统衰老的方法。 将老年（22-26个月大）小鼠的T细胞的Fas表达和功能与年轻（2月龄）的小鼠和老的CD2-fas转基因小鼠进行比较。 与老年小鼠相比，来自老鼠的T细胞的Fas表达和配体诱导的凋亡降低。 在26个月大的CD2-fas转基因小鼠中，Fas和CD44表达，Fas诱导的凋亡，T细胞增殖和细胞因子产生与年轻小鼠相当。 这些结果表明，随着年龄的增长，T细胞衰老与细胞凋亡有关，CD2-fas转基因能够维持老年小鼠Fas细胞凋亡功能和T细胞功能，与年轻小鼠相当。