公开(公告)号：US20200276208A1

公开(公告)日：2020-09-03

申请号：US16597065

申请日：2019-10-09

申请人： Tonix Pharma Holdings Limited

发明人： Stefano Luca Giaffreda ,  Enrico Modena ,  Serena Fabbroni ,  Michel Chiarucci ,  Mark T. Edgar

IPC分类号： A61K31/554 ,  C07D281/02

摘要： Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I:

公开(公告)号：US10946027B2

公开(公告)日：2021-03-16

申请号：US16597065

申请日：2019-10-09

申请人： Tonix Pharma Holdings Limited

发明人： Stefano Luca Giaffreda ,  Enrico Modena ,  Serena Fabbroni ,  Michel Chiarucci ,  Mark T. Edgar

IPC分类号： A61K31/554 ,  A61P25/24 ,  C07D281/02

摘要： Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I:

公开(公告)号：US10449203B2

公开(公告)日：2019-10-22

申请号：US15856818

申请日：2017-12-28

申请人： Tonix Pharma Holdings Limited

发明人： Stefano Luca Giaffreda ,  Enrico Modena ,  Serena Fabbroni ,  Michel Chiarucci ,  Mark T. Edgar

IPC分类号： C07D281/02 ,  A61K31/554 ,  A61P25/24

摘要： Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I:

公开(公告)号：US20180338984A1

公开(公告)日：2018-11-29

申请号：US15856818

申请日：2017-12-28

申请人： Tonix Pharma Holdings Limited

发明人： Stefano Luca Giaffreda ,  Enrico Modena ,  Serena Fabbroni ,  Michel Chiarucci ,  Mark T. Edgar

IPC分类号： A61K31/554

摘要： Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I: