公开(公告)号：US20090048445A1

公开(公告)日：2009-02-19

申请号：US11991799

申请日：2006-10-16

申请人： Toru Takabatake ,  Hiroaki Saito ,  Yusuke Sumiyoshi

发明人： Toru Takabatake ,  Hiroaki Saito ,  Yusuke Sumiyoshi

IPC分类号： C07D241/36 ,  C07D271/12

CPC分类号： C07D241/52

摘要： There is disclosed a method of synthesizing a quinoxaline derivative in which toxicity, corrosiveness and permeation are low and which is excellent in safety and which attains a reduced reaction time, a greatly improved yield and excellent economical efficiency. The object is achieved by a method of synthesizing a quinoxaline derivative which comprises adsorbing a benzofuroxan derivative and a β-diketone derivative on a solid support, and then heating the derivatives in a solid state by microwave irradiation to dehydrocyclize them.

摘要翻译： 公开了一种合成喹喔啉衍生物的方法，其中毒性，腐蚀性和渗透性低，安全性优异，反应时间缩短，产率大幅提高，经济效益优良。 该目的通过合成喹喔啉衍生物的方法来实现，该方法包括将苯并呋喃衍生物和β-二酮衍生物吸附在固体支持物上，然后通过微波辐射加热固体衍生物以使其脱氢环化。

公开(公告)号：US07968713B2

公开(公告)日：2011-06-28

申请号：US11991799

申请日：2006-10-16

申请人： Toru Takabatake ,  Hiroaki Saito ,  Yusuke Sumiyoshi

发明人： Toru Takabatake ,  Hiroaki Saito ,  Yusuke Sumiyoshi

IPC分类号： C07D241/36

CPC分类号： C07D241/52

摘要： There is disclosed a method of synthesizing a quinoxaline derivative in which toxicity, corrosiveness and permeation are low and which is excellent in safety and which attains a reduced reaction time, a greatly improved yield and excellent economical efficiency. The object is achieved by a method of synthesizing a quinoxaline derivative which comprises adsorbing a benzofuroxan derivative and a β-diketone derivative on a solid support, and then heating the derivatives in a solid state by microwave irradiation to dehydrocyclize them. An example of a quinoxaline derivative is a compound of formula (4):

摘要翻译： 公开了一种合成喹喔啉衍生物的方法，其中毒性，腐蚀性和渗透性低，安全性优异，反应时间缩短，产率大幅提高，经济效益优良。 该目的通过合成喹喔啉衍生物的方法来实现，该方法包括在固体支持物上吸附苯并呋喃衍生物和β-二酮衍生物，然后通过微波照射加热固体衍生物以使其脱氢环化。 喹喔啉衍生物的实例是式（4）的化合物：