公开(公告)号：US20050069891A1

公开(公告)日：2005-03-31

申请号：US10501647

申请日：2003-01-15

申请人： Toshiaki Susuki ,  Naoyuki Kamatani ,  Junji Tanaka

发明人： Toshiaki Susuki ,  Naoyuki Kamatani ,  Junji Tanaka

IPC分类号： C12N15/09 ,  C12Q1/68

CPC分类号： G16B20/00

摘要： The present invention is intended to provide a technique relating to a method of specifying an SNP which comprises repeating presumption of an SNP serving as a marker and detailed typing of SNPs around the same, thus gradually narrowing down the focus to the base sequence domain in which the ‘target’ SNP is likely contained and finally specifying the ‘target’ SNP at a high efficiency. As FIG. 1 shows, the method of specifying an SNP comprises: (1) determining a drug to be developed which is the subject of the determination; (2) collecting samples to be analyzed; (3) determining a ‘scanning domain (base sequence domain)’; (4) determining ‘typing’ SNPs; (5) SNP typing by the wet process and analyzing haplotypes based on the typing data; (6) presuming a ‘marker’ SNP (determining the analytical data); and (7) specifying the ‘target’ SNP (target SNP). A cycle consisting of the stage (1) to (7) is repeated as a treatment cycle.

摘要翻译： 本发明旨在提供一种涉及一种指定SNP的方法的技术，其包括重复将SNP作为标记的推测，并且在其周围的SNP的详细分型，从而逐渐将焦点缩小到碱基序列区，其中 “目标”SNP可能包含在内，最终以高效率指定“目标”SNP。 如图。 如图1所示，指定SNP的方法包括：（1）确定作为确定对象的待开发药物; （2）收集待分析样品; （3）确定“扫描域（碱基序列域）”; （4）确定“打字”SNP; （5）通过湿法进行SNP分型，并根据分型数据分析单体型; （6）假设“标记”SNP（确定分析数据）; 和（7）指定“目标”SNP（目标SNP）。 重复由阶段（1）至（7）组成的周期作为治疗周期。