公开(公告)号：US20120114738A1

公开(公告)日：2012-05-10

申请号：US13351750

申请日：2012-01-17

申请人： Toshikazu KOMODA ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

发明人： Toshikazu KOMODA ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

IPC分类号： A61K9/70 ,  A61K31/136

CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/10

摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2′,5′-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30.

摘要翻译： 本发明提供了具有优异的DMAE或其药理学上可接受的盐的保存稳定性和透皮吸收性的透皮贴剂。 贴剂在支撑体的一个表面上具有一体层压的支撑体和石膏层，石膏层包括：2-氨基-1-（2'，5'-二甲氧基苯基）乙醇或其药理学上可接受的盐; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有烷基的丙烯酸烷基酯的单体共聚而成的丙烯酸粘合剂为40〜98重量％ 碳数为2〜20; 和1〜30重量％的具有碳原子数为10〜30的烷基的饱和脂肪族一元醇。