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    Transdermal patch
    1.
    发明申请
    Transdermal patch 审中-公开
    透皮贴片

    公开(公告)号：US20090258063A1

    公开(公告)日：2009-10-15

    申请号：US12310840

    申请日：2007-09-11

    申请人： Hiroko Udagawa ,  Toshikazu Komoda ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    发明人： Hiroko Udagawa ,  Toshikazu Komoda ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    IPC分类号： A61K9/70 ,  A61P9/12

    CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/14

    摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAEs. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: DMAEs; an acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and fatty acid ester prepared by dehydro-condensing saturated fatty acid having an alkyl group with a carbon number of 10 to 20 and saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 2 to 20, wherein solubility of the DMAEs is 0.05 to 5 g at 25° C. with respect to the fatty acid ester.

    摘要翻译： 本发明提供了具有优异的DMAE保存稳定性和透皮吸收性的透皮贴片。 补片具有一体地层叠在支撑体的一个表面上的支撑体和石膏层，并且膏药层包括：DMAE; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有碳原子数为2的烷基的丙烯酸烷基酯的丙烯酸粘合剂 到20 和通过使具有碳原子数为10〜20的烷基的饱和脂肪酸和碳数为2〜20的烷基的饱和脂肪族一元醇脱水缩合而制备的脂肪酸酯，其中DMAE的溶解度为0.05〜 在25℃下相对于脂肪酸酯为5g。

    TRANSDERMAL PATCH
    2.
    发明申请
    TRANSDERMAL PATCH 审中-公开
    透明贴

    公开(公告)号：US20120171274A1

    公开(公告)日：2012-07-05

    申请号：US13351724

    申请日：2012-01-17

    申请人： Hiroko Udagawa ,  Toshikazu Komoda ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    发明人： Hiroko Udagawa ,  Toshikazu Komoda ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    IPC分类号： A61K9/70 ,  A61P9/00 ,  A61K31/137

    CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/14

    摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAEs. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: DMAEs; an acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and fatty acid ester prepared by dehydro-condensing saturated fatty acid having an alkyl group with a carbon number of 10 to 20 and saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 2 to 20, wherein solubility of the DMAEs is 0.05 to 5 g at 25° C. with respect to the fatty acid ester.

    摘要翻译： 本发明提供了具有优异的DMAE保存稳定性和透皮吸收性的透皮贴片。 补片具有一体地层叠在支撑体的一个表面上的支撑体和石膏层，并且膏药层包括：DMAE; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有碳数为2的烷基的丙烯酸烷基酯的丙烯酸粘合剂 到20 和通过使具有碳原子数为10〜20的烷基的饱和脂肪酸和碳数为2〜20的烷基的饱和脂肪族一元醇脱水缩合而制备的脂肪酸酯，其中DMAE的溶解度为0.05〜 在25℃下相对于脂肪酸酯为5g。

    TRANSDERMAL PATCH
    3.
    发明申请
    TRANSDERMAL PATCH 审中-公开
    透明贴

    公开(公告)号：US20120114738A1

    公开(公告)日：2012-05-10

    申请号：US13351750

    申请日：2012-01-17

    申请人： Toshikazu KOMODA ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    发明人： Toshikazu KOMODA ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    IPC分类号： A61K9/70 ,  A61K31/136

    CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/10

    摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2′,5′-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30.

    摘要翻译： 本发明提供了具有优异的DMAE或其药理学上可接受的盐的保存稳定性和透皮吸收性的透皮贴剂。 贴剂在支撑体的一个表面上具有一体层压的支撑体和石膏层，石膏层包括：2-氨基-1-（2'，5'-二甲氧基苯基）乙醇或其药理学上可接受的盐; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有烷基的丙烯酸烷基酯的单体共聚而成的丙烯酸粘合剂为40〜98重量％ 碳数为2〜20; 和1〜30重量％的具有碳原子数为10〜30的烷基的饱和脂肪族一元醇。

    Transdermal patch
    4.
    发明申请
    Transdermal patch 审中-公开
    透皮贴片

    公开(公告)号：US20090317452A1

    公开(公告)日：2009-12-24

    申请号：US12310845

    申请日：2007-09-11

    申请人： Toshikazu Komoda ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    发明人： Toshikazu Komoda ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    IPC分类号： A61K9/70 ,  A61K31/136 ,  A61P9/02

    CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/10

    摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2′,5′-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30.

    摘要翻译： 本发明提供了具有优异的DMAE或其药理学上可接受的盐的保存稳定性和透皮吸收性的透皮贴剂。 贴剂在支撑体的一个表面上具有一体层压的支撑体和石膏层，石膏层包括：2-氨基-1-（2'，5'-二甲氧基苯基）乙醇或其药理学上可接受的盐; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有烷基的丙烯酸烷基酯的单体共聚而成的丙烯酸粘合剂为40〜98重量％ 碳数为2〜20; 和1〜30重量％的具有碳原子数为10〜30的烷基的饱和脂肪族一元醇。

    Indole derivatives substituted with long-chain alcohols and medicaments containing them
    6.
    发明授权
    Indole derivatives substituted with long-chain alcohols and medicaments containing them 失效
    被长链醇取代的吲哚衍生物和含有它们的药物

    公开(公告)号：US07902249B2

    公开(公告)日：2011-03-08

    申请号：US12132345

    申请日：2008-06-03

    申请人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    发明人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    IPC分类号： A61K31/404 ,  C07D209/04

    CPC分类号： C07D209/12

    摘要： Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.

    摘要翻译： 提供由下式（I）表示的吲哚长链醇或其水合物或异构体：其中R1，R2，R3和R4各自独立地表示氢原子，甲基，乙酰基或 羟基，n表示0〜20的数; 以及含有该组合物的药物组合物。 吲哚长链醇（I）表现出优异的神经生长促进作用，以及有效的抗氧化和抗肿瘤作用，因此可用作脑疾病包括痴呆症和恶性肿瘤的预防和/或治疗剂 包括脑肿瘤。