公开(公告)号：US4794118A

公开(公告)日：1988-12-27

申请号：US887720

申请日：1986-07-18

申请人： Toshinobu Kunii ,  Norio Minami ,  Fumihiro Ozaki ,  Nobuyuki Mori ,  Mikio Takeda ,  Hiroshi Katoh

发明人： Toshinobu Kunii ,  Norio Minami ,  Fumihiro Ozaki ,  Nobuyuki Mori ,  Mikio Takeda ,  Hiroshi Katoh

IPC分类号： C07D319/16 ,  A61K31/335 ,  A61K31/357 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D319/20 ,  C07D405/12 ,  C07D413/12

CPC分类号： C07D405/12 ,  C07D319/20

摘要： 1,4-Benzodioxane derivatives represented by the following general formula: ##STR1## wherein p stands for an integer of 0-2, X and Y are same or different, and each represent a hydrogen atom; or a group represented by the formula --OR in which R denotes a hydrogen atom, a lower alkyl, lower alkoxycarbonyl or acyl group, or a group represented by the formula ##STR2## m being an integer of 1 or 2; cyano group; or carboxy group, n is an integer of 1-3, exclusive of the case wherein p=0 and X=Y=H, or a pharmacologically acceptable salt thereof. Their process for the preparation, their use as therpeutic and/or preventive compositions for ischemic heart diseases and heart failure and their application for the control of blood pressure during surgical operations are also described.

公开(公告)号：US4959376A

公开(公告)日：1990-09-25

申请号：US253023

申请日：1988-10-04

申请人： Toshinobu Kunii ,  Norio Minami ,  Fumihiro Ozaki ,  Nobuyuki Mori ,  Mikio Takeda ,  Hiroshi Katoh

发明人： Toshinobu Kunii ,  Norio Minami ,  Fumihiro Ozaki ,  Nobuyuki Mori ,  Mikio Takeda ,  Hiroshi Katoh

IPC分类号： C07D319/16 ,  A61K31/335 ,  A61K31/357 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D319/20 ,  C07D405/12

CPC分类号： C07D405/12 ,  C07D319/20

摘要： 1,4-Benzodioxane derivatives represented by the following general formula: ##STR1## wherein p stands for an integer of 0-2, X and Y are same or different, and each represent a hydrogen atom; or a group represented by the formula --OR in which R denotes a hydrogen atom, a lower alkyl, lower alkoxycarbonyl or acyl group, or a group represented by the formula ##STR2## m being an integer of 1 or 2; cyano group; or carboxy group, n is an integer of 1-3, exclusive of the case wherein p=0 and X=Y=H, or a pharmacologically acceptable salt thereof. Their process for the preparation, their use as therapeutic and/or preventive compositions for ischemic heart diseases and heart failure and their application for the control of blood pressure during surgical operations are also described.

公开(公告)号：US4540704A

公开(公告)日：1985-09-10

申请号：US500801

申请日：1983-06-07

申请人： Kouichiro Ueda ,  Satoru Tanaka ,  Toshinobu Kunii ,  Kengo Kagei ,  Tadashi Sato ,  Ono Hideki ,  Issei Ohtsuka ,  Mayumi Kawase ,  Toshiharu Ohgoh ,  Tsuneo Wakabayashi

发明人： Kouichiro Ueda ,  Satoru Tanaka ,  Toshinobu Kunii ,  Kengo Kagei ,  Tadashi Sato ,  Ono Hideki ,  Issei Ohtsuka ,  Mayumi Kawase ,  Toshiharu Ohgoh ,  Tsuneo Wakabayashi

IPC分类号： A61K31/415 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/02 ,  A61P27/02 ,  A61P27/12 ,  C07D233/72 ,  C07D491/107 ,  C07D493/10 ,  C07D495/10

CPC分类号： C07D493/10 ,  C07D495/10

摘要： Novel hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, independently represent a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; Y represents an oxygen atom or sulfur atom, R.sub.1 and R.sub.2, which may be the same or different, independently represent a hydrogen atom, a lower alkyl group or phenyl group, or both may form a ring with carbon atoms, excluding the case wherein both R.sub.1 and R.sub.2 are hydrogen atom, and n represents 0 or 1. The novel hydantoin derivatives and salts thereof have excellent effects for the treatment of the complications of diabetes mellitus.

摘要翻译： 新颖的乙内酰脲衍生物及其盐，其制备方法和含有它们的药物，其中乙内酰脲衍生物由以下通式表示：其中X1和X2可以相同或不同，独立地表示 氢原子，卤素原子，低级烷基或低级烷氧基; Y表示氧原子或硫原子，可以相同或不同的R 1和R 2独立地表示氢原子，低级烷基或苯基，或两者可以形成具有碳原子的环，不同之处在于两者 R1和R2是氢原子，n代表0或1.新的乙内酰脲衍生物及其盐具有治疗糖尿病并发症的优异效果。

公开(公告)号：US4780472A

公开(公告)日：1988-10-25

申请号：US117887

申请日：1987-11-02

申请人： Kouichiro Ueda ,  Satoru Tanaka ,  Toshinobu Kunii ,  Kengo Kagei ,  Tadashi Sato ,  Hideki Ono ,  Issei Ohtsuka ,  Mayumi Kawase ,  Toshiharu Ohgoh ,  Tsuneo Wakabayashi

发明人： Kouichiro Ueda ,  Satoru Tanaka ,  Toshinobu Kunii ,  Kengo Kagei ,  Tadashi Sato ,  Hideki Ono ,  Issei Ohtsuka ,  Mayumi Kawase ,  Toshiharu Ohgoh ,  Tsuneo Wakabayashi

IPC分类号： A61K31/415 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/02 ,  A61P27/02 ,  A61P27/12 ,  C07D233/72 ,  C07D491/107 ,  C07D493/10 ,  C07D495/10

CPC分类号： C07D493/10 ,  C07D495/10

摘要： Hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein the substituents are defined hereinbelow. The hydantoin derivatives and salts thereof have excellent effects for the treamtment of the complications of the diabetes mellitus.

摘要翻译： 乙内酰脲衍生物及其盐，其制备方法和含有其的药物，其中乙内酰脲衍生物由以下通式表示：其中取代基在下文定义。 乙内酰脲衍生物及其盐对糖尿病并发症的改善具有优异的效果。

公开(公告)号：US4874869A

公开(公告)日：1989-10-17

申请号：US73915

申请日：1987-07-13

申请人： Kouichiro Ueda ,  Satoru Tanaka ,  Toshinobu Kunii ,  Kengo Kagei ,  Tadashi Sato ,  Hideki Ono ,  Issei Ohtsuka ,  Mayumi Kawase ,  Toshiharu Ohgoh ,  Tsuneo Wakabayashi

发明人： Kouichiro Ueda ,  Satoru Tanaka ,  Toshinobu Kunii ,  Kengo Kagei ,  Tadashi Sato ,  Hideki Ono ,  Issei Ohtsuka ,  Mayumi Kawase ,  Toshiharu Ohgoh ,  Tsuneo Wakabayashi

IPC分类号： A61K31/415 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/02 ,  A61P27/02 ,  A61P27/12 ,  C07D233/72 ,  C07D491/107 ,  C07D493/10 ,  C07D495/10

CPC分类号： C07D493/10 ,  C07D495/10

摘要： Novel hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, mean independently hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; Y means oxygen atom or sulfur atom, R.sub.1 and R.sub.2, which may be the same or different, mean independently hydrogen atom, a lower alkyl group or phenyl group, or the both may form a ring with a carbon atom which is combined with them, excluding the case wherein both R.sub.1 and R.sub.2 are hydrogen atom at the same time, and n means an integer of 0 or 1. The novel hydantoin derivatives and salts thereof have excellent effects for the treatment of the complications of the diabetes mellitus.

摘要翻译： 新颖的乙内酰脲衍生物及其盐，其制备方法和含有它们的药物，其中乙内酰脲衍生物由以下通式表示：其中X1和X2可以相同或不同，独立地表示氢 原子，卤素原子，低级烷基或低级烷氧基; Y表示氧原子或硫原子，可以相同或不同的R 1和R 2独立地表示氢原子，低级烷基或苯基，或者二者可以与与它们结合的碳原子形成环， 不包括R1和R2同时为氢原子的情况，n表示0或1的整数。新的乙内酰脲衍生物及其盐对于治疗糖尿病并发症具有优异的效果。