公开(公告)号：US20120276531A1

公开(公告)日：2012-11-01

申请号：US13415508

申请日：2012-03-08

申请人： Toshiyuki Saito ,  Yoji Mikami ,  Masahiro Kinugasa ,  Kazuya Mori ,  Michiyo Sugimoto ,  Koji Uchida

发明人： Toshiyuki Saito ,  Yoji Mikami ,  Masahiro Kinugasa ,  Kazuya Mori ,  Michiyo Sugimoto ,  Koji Uchida

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： To provide a novel method for determining the risk of lymph node metastasis of breast cancer uses as an index the difference in the expression levels of marker genes in at least one material selected from the group consisting of a breast tissue and a breast cell of a patient. The method includes measuring an expression level of a marker gene in at least one material selected from the group consisting of a breast tissue and a breast cell of a patient with breast cancer, and determining the risk of lymph node metastasis of breast cancer in the patient using the expression level of the marker gene as an index.

摘要翻译： 提供一种用于确定乳腺癌用途的淋巴结转移的风险的新方法作为指标，其选自由患者的乳房组织和乳腺细胞组成的组中的至少一种材料中的标记基因的表达水平的差异 。 该方法包括测量在选自乳腺组织和乳腺癌患者的乳腺细胞的至少一种材料中的标记基因的表达水平，并确定患者中乳腺癌淋巴结转移的风险 使用标记基因的表达水平作为指标。

公开(公告)号：US20090011423A1

公开(公告)日：2009-01-08

申请号：US12183610

申请日：2008-07-31

申请人： Toshiyuki Saito ,  Yoji Mikami ,  Masahiro Kinugasa ,  Kazuya Mori ,  Michiyo Sugimoto ,  Koji Uchida

发明人： Toshiyuki Saito ,  Yoji Mikami ,  Masahiro Kinugasa ,  Kazuya Mori ,  Michiyo Sugimoto ,  Koji Uchida

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： To provide a novel method for determining the risk of lymph node metastasis of breast cancer uses as an index the difference in the expression levels of marker genes between metastatic breast cancer tissue (or cell) and non-metastatic breast cancer tissue (or cell). The method involves (1) measuring the expression level of a gene having a base sequence in human metastatic breast cancer tissue (or cell), (2) measuring the expression level of the same gene in human non-metastatic breast cancer tissue (or cell), and (3) comparing the expression level of (1) with the expression level of (2) and determine the risk of lymph node metastasis of breast cancer based on the difference between the expression levels.

摘要翻译： 提供一种确定乳腺癌淋巴结转移风险的新方法作为转移性乳腺癌组织（或细胞）与非转移性乳腺癌组织（或细胞）之间标记基因表达水平差异的指标。 该方法包括（1）测量人转移性乳腺癌组织（或细胞）中具有碱基序列的基因的表达水平，（2）测量人非转移性乳腺癌组织（或细胞）中相同基因的表达水平 ）和（3）比较（1）的表达水平与（2）的表达水平，并根据表达水平之间的差异确定乳腺癌淋巴结转移的风险。