公开(公告)号：US12240824B2

公开(公告)日：2025-03-04

申请号：US17058574

申请日：2019-05-29

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Saswata Karmakar ,  Frank DeRosa ,  Michael Heartlein

IPC: C07C401/00 ,  A61K9/127 ,  C07C225/14 ,  C07C229/12 ,  C07C323/25 ,  C07C323/27 ,  C07C403/12 ,  C07D311/20 ,  A61K31/592 ,  A61K31/593

Abstract: Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20230071228A1

公开(公告)日：2023-03-09

申请号：US17291937

申请日：2019-11-07

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Frank DeRosa ,  Shrirang Karve ,  Michael Heartlein ,  Saswata Karmakar ,  Ryan Landis

IPC: C07D241/04 ,  A61K47/24 ,  A61K31/7105 ,  A61K9/127

Abstract: The present invention provides, in part, cyclic amino acid lipid compounds of formula (A′), and sub-formulas thereof or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20220177423A1

公开(公告)日：2022-06-09

申请号：US17604244

申请日：2020-04-17

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Saswata Karmakar ,  Frank DeRosa

IPC: C07C323/58 ,  A61K9/127 ,  A61K38/17 ,  A61K38/45

Abstract: The present invention provides, in part cystine cationic lipid compounds of formula A, and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20210206739A1

公开(公告)日：2021-07-08

申请号：US17058574

申请日：2019-05-29

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Saswata Karmakar ,  Frank DeRosa ,  Michael Heartlein

IPC: C07D311/20 ,  C07C225/14 ,  C07C229/12 ,  C07C323/25 ,  C07C323/27 ,  C07C403/12

Abstract: Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.