公开(公告)号：US20180153822A1

公开(公告)日：2018-06-07

申请号：US15809680

申请日：2017-11-10

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Frank DeRosa ,  Zarna Bhavsar ,  Michael Heartlein

IPC: A61K9/51 ,  A61K38/53 ,  A61K38/44 ,  A61K38/18 ,  A61K38/17 ,  A61K38/45

CPC classification number: A61K9/5192 ,  A61K9/1272 ,  A61K9/5123 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/44 ,  A61K38/45 ,  A61K38/53 ,  A61K47/22 ,  A61K47/28 ,  C12N15/88 ,  C12Y114/16001 ,  C12Y201/03003 ,  C12Y603/04005

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA.

公开(公告)号：US20240041789A1

公开(公告)日：2024-02-08

申请号：US18328206

申请日：2023-06-02

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Frank DeRosa ,  Zarna Bhavsar ,  Michael Heartlein

IPC: A61K9/51 ,  A61K38/45 ,  A61K38/18 ,  A61K38/17 ,  A61K38/44 ,  A61K38/53 ,  A61K9/127 ,  A61K47/22 ,  C12N15/88 ,  A61K47/28

CPC classification number: A61K9/5192 ,  A61K9/5123 ,  A61K38/45 ,  C12Y201/03003 ,  A61K38/1816 ,  C12Y603/04005 ,  A61K38/177 ,  A61K38/44 ,  C12Y114/16001 ,  A61K38/53 ,  A61K9/1272 ,  A61K47/22 ,  C12N15/88 ,  A61K47/28

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA.

公开(公告)号：US20230065040A1

公开(公告)日：2023-03-02

申请号：US17841194

申请日：2022-06-15

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Frank DeRosa ,  Zarna Bhavsar ,  Michael Heartlein

IPC: A61K31/7105 ,  A61K9/127 ,  A61P3/00 ,  A61K38/45 ,  C12N9/26 ,  A61K9/00 ,  A61K47/69 ,  A61K38/47

Abstract: The present invention provides, among other things, methods of formulating nucleic acid-containing nanoparticles with an enzyme to afford efficient delivery of payload to a cell or tissue of interest via subcutaneous administration. In some embodiments, the present invention provides a process in which mRNA-loaded lipid nanoparticles are co-mixed with various amounts of hyaluronidase and administered via subcutaneous administration. The resulting payload can be efficiently delivered to the liver and other organs or tissues of a treated subject.

公开(公告)号：US20210220449A1

公开(公告)日：2021-07-22

申请号：US17055251

申请日：2019-05-14

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Frank DeRosa ,  Zarna Bhavsar ,  Michael Heartlein

IPC: A61K38/47 ,  A61K47/54 ,  A61K31/7105 ,  A61K9/51

Abstract: The present invention provides, among other things, methods of formulating nucleic acid-containing nanoparticles with an mRNA encoding an enzyme to afford efficient delivery of payload to a cell or tissue of interest via subcutaneous administration. The resulting payload can be efficiently delivered to the liver and other organs or tissues of a treated subject.

公开(公告)号：US20190298755A1

公开(公告)日：2019-10-03

申请号：US16349229

申请日：2017-11-10

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Frank DeRosa ,  Zarna Bhavsar ,  Michael Heartlein

IPC: A61K31/7105 ,  A61P3/00 ,  C12N9/26 ,  A61K9/00 ,  A61K38/47 ,  A61K9/127 ,  A61K47/69

Abstract: The present invention provides, among other things, methods of formulating nucleic acid-containing nanoparticles with an enzyme to afford efficient delivery of payload to a cell or tissue of interest via subcutaneous administration. In some embodiments, the present invention provides a process in which mRNA-loaded lipid nanoparticles are co-mixed with various amounts of hyaluronidase and administered via subcutaneous administration. The resulting payload can be efficiently delivered to the liver and other organs or tissues of a treated subject.