公开(公告)号：US12018066B1

公开(公告)日：2024-06-25

申请号：US17514903

申请日：2021-10-29

Applicant: Triad National Security, LLC

Inventor： Antonietta Maria Lillo ,  Nileena Velappan ,  Geoffrey S. Waldo

IPC: C07K16/00 ,  C07K16/10

CPC classification number: C07K16/10 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/92

Abstract: The invention provides antibodies that specifically bind the SARS-CoV-2 receptor binding domain. The antibodies are useful in treating SARS-CoV-2 virus infection and in diagnostic methods, agents, and kits thereof.

公开(公告)号：US11702465B1

公开(公告)日：2023-07-18

申请号：US17033516

申请日：2020-09-25

Applicant: Triad National Security, LLC

Inventor： Antonietta Maria Lillo ,  Nileena Velappan ,  Armand Earl Ko Dichosa ,  Stosh Anthony Kozimor ,  Laura Margaret Lilley

IPC: C07K16/12 ,  A61K51/10 ,  A61P31/06 ,  G01N33/569 ,  A61K39/00

CPC classification number: C07K16/1228 ,  A61K51/1009 ,  A61P31/06 ,  G01N33/56916 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30 ,  G01N2800/26

Abstract: Monoclonal antibodies that specifically bind the F1 antigen of Yersinia pestis with high affinity are described. Use of the monoclonal antibodies for the detection of Y. pestis infection and the diagnosis of plague are also described. Immunoconjugates of the monoclonal antibodies and a radionuclide can also be used for the treatment of a Y. pestis infection.