公开(公告)号：US20180169134A1

公开(公告)日：2018-06-21

申请号：US15895677

申请日：2018-02-13

申请人： Tricol Biomedical, Inc.

发明人： Simon McCarthy ,  Barbara McGrath ,  Sam Kuhn ,  Jess Kimball ,  Michael Stolten ,  Amanda Bennett

IPC分类号： A61K31/722 ,  A61K9/19 ,  A61K9/16 ,  A61K47/12 ,  A61K9/70

CPC分类号： A61K31/722 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/19 ,  A61K9/70 ,  A61K47/12

摘要： The present invention comprises chitosan materials and methods of using carbonic acid for aqueous solubilization of neutralized or pre-treated chitosan gels and provides, among other things, substantially acid salt free composition native final forms without requiring subsequent acid salt elution. The invention includes chitosan-based solid and semi-solid material forms, optionally reinforced with chitosan fibers, such as powders, fibers, films, matrices, sponges, implants, scaffolds, fillers, and hydrogels. Native final forms are produced from chitosan powder solubilized in an aqueous acidic solution, processed to form a high pH hydrated chitosan gel precipitate material that is then neutralized by water washing and re-solubilized substantially to chitosan solution using carbonic acid. Chitosan materials can be mixed in solution with one or more of other hydrophilic polymers to create compositional heterogeneity and pharmaceutical agents to achieve controlled release of the agent(s) from the final forms at the site of application.

公开(公告)号：US11234998B2

公开(公告)日：2022-02-01

申请号：US16821459

申请日：2020-03-17

申请人： Tricol Biomedical, Inc.

发明人： Simon McCarthy ,  Barbara McGrath ,  Sam Kuhn ,  Jess Kimball ,  Michael Stolten ,  Amanda Bennett

IPC分类号： A61K31/722 ,  A61K9/70 ,  A61K47/12 ,  A61K9/16 ,  A61K9/19

摘要： The present invention comprises chitosan materials and methods of using carbonic acid for aqueous solubilization of neutralized or pre-treated chitosan gels and provides, among other things, substantially acid salt free composition native final forms without requiring subsequent acid salt elution. The invention includes chitosan-based solid and semi-solid material forms, optionally reinforced with chitosan fibers, such as powders, fibers, films, matrices, sponges, implants, scaffolds, fillers, and hydrogels. Native final forms are produced from chitosan powder solubilized in an aqueous acidic solution, processed to form a high pH hydrated chitosan gel precipitate material that is then neutralized by water washing and re-solubilized substantially to chitosan solution using carbonic acid. Chitosan materials can be mixed in solution with one or more of other hydrophilic polymers to create compositional heterogeneity and pharmaceutical agents to achieve controlled release of the agent(s) from the final forms at the site of application.

公开(公告)号：US09925210B2

公开(公告)日：2018-03-27

申请号：US14614316

申请日：2015-02-04

申请人： Tricol Biomedical, Inc.

发明人： Simon McCarthy ,  Barbara McGrath ,  Sam Kuhn ,  Jess Kimball ,  Michael Stolten ,  Amanda Bennett

IPC分类号： A61K31/722 ,  A61K9/19 ,  A61K9/16 ,  A61K47/12 ,  A61K9/70

CPC分类号： A61K31/722 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/19 ,  A61K9/70 ,  A61K47/12

摘要： The present invention comprises chitosan materials and methods of using carbonic acid for aqueous solubilization of neutralized or pre-treated chitosan gels and provides, among other things, substantially acid salt free composition native final forms without requiring subsequent acid salt elution. The invention includes chitosan-based solid and semi-solid material forms, optionally reinforced with chitosan fibers, such as powders, fibers, films, matrices, sponges, implants, scaffolds, fillers, and hydrogels. Native final forms are produced from chitosan powder solubilized in an aqueous acidic solution, processed to form a high pH hydrated chitosan gel precipitate material that is then neutralized by water washing and re-solubilized substantially to chitosan solution using carbonic acid. Chitosan materials can be mixed in solution with one or more of other hydrophilic polymers to create compositional heterogeneity and pharmaceutical agents to achieve controlled release of the agent(s) from the final forms at the site of application.