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公开(公告)号：US20180193531A1
公开(公告)日：2018-07-12
申请号：US15895674
申请日：2018-02-13
发明人： Barbara McGrath , Simon McCarthy , Sam Kuhn , Alysha Wold , Michael Stolten , Amanda Bennett
摘要： The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
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公开(公告)号：US20170232134A1
公开(公告)日：2017-08-17
申请号：US15431168
申请日：2017-02-13
发明人： Brian Clare , Radim Dvorák , Simon McCarthy , Jiri Machát
CPC分类号： A61L15/28 , A61L15/425 , A61L24/0036 , A61L24/08 , A61L2400/04 , A61L2430/00 , D01D1/02 , D01D5/08 , D01D5/084 , D01D5/18 , D01D10/02 , D01F1/02 , D01F9/00 , C08L5/08
摘要： The present chitosan-based superfine fiber invention relates to compositions, formulations, and processes that result in numerous significant advantages for the production and use of superfine fiber bioactive matrices in biomedical applications. The present invention relates to superfine, chitosan-based fibers, wherein the chitosan-based fibers have a percentage chitosan content of at least about 20% w/w, and highly conformable and compliant matrices comprising such fibers, processes for their production, and related formulations. The superfine chitosan-based fibers of the invention preferably include microfibers with diameter less than or equal to about 10 microns and micron and submicron fibers that are about 2 microns and less.
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公开(公告)号：US11229724B2
公开(公告)日：2022-01-25
申请号：US16892865
申请日：2020-06-04
发明人： Barbara McGrath , Simon McCarthy , Sam Kuhn , Alysha Wold , Michael Stolten , Amanda Bennett
IPC分类号： A61L27/26 , A61L27/58 , C08L5/08 , C08B37/08 , A61K47/36 , A61K9/00 , A61K49/00 , G01N33/50 , G01N33/68 , A61L27/20 , C08L89/06
摘要： The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
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公开(公告)号：US11160901B2
公开(公告)日：2021-11-02
申请号：US15565388
申请日：2016-04-11
发明人： Maggie Bush , Sam Kuhn , Simon McCarthy
IPC分类号： A61L24/08 , A61L24/00 , C08L5/08 , A61K47/36 , A61K47/10 , A61K31/155 , A61K47/14 , A61K47/02 , A61K31/785 , A61K47/12 , A61K9/06
摘要： An aqueous chitosan gel system of novel non-scarring, non-interfering, transparent, stable, solubilized chitosan that controls bleeding is described herein. The aqueous chitosan gel system can comprise water, chitosan, an acid, a plasticizer, a rheology modifying agent, an antioxidant stabilizer, an alcohol, and a multi-valent salt. Additional components of the aqueous chitosan gel system can comprise a bifunctional organic acid, a tnfunctional organic acid, a multi-functional organic acid, a phosphoric acid, a polyphosphoric acid and a salt.
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公开(公告)号：US10709817B2
公开(公告)日：2020-07-14
申请号：US15895674
申请日：2018-02-13
发明人： Barbara McGrath , Simon McCarthy , Sam Kuhn , Alysha Wold , Michael Stolten , Amanda Bennett
IPC分类号： A61L27/26 , C08L89/06 , C08L5/08 , G01N33/50 , A61L27/58 , A61L27/20 , C08B37/08 , A61K47/36 , A61K9/00 , A61K49/00 , G01N33/68
摘要： The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
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公开(公告)号：US20180169134A1
公开(公告)日：2018-06-21
申请号：US15895677
申请日：2018-02-13
发明人： Simon McCarthy , Barbara McGrath , Sam Kuhn , Jess Kimball , Michael Stolten , Amanda Bennett
IPC分类号： A61K31/722 , A61K9/19 , A61K9/16 , A61K47/12 , A61K9/70
CPC分类号： A61K31/722 , A61K9/1652 , A61K9/1694 , A61K9/19 , A61K9/70 , A61K47/12
摘要： The present invention comprises chitosan materials and methods of using carbonic acid for aqueous solubilization of neutralized or pre-treated chitosan gels and provides, among other things, substantially acid salt free composition native final forms without requiring subsequent acid salt elution. The invention includes chitosan-based solid and semi-solid material forms, optionally reinforced with chitosan fibers, such as powders, fibers, films, matrices, sponges, implants, scaffolds, fillers, and hydrogels. Native final forms are produced from chitosan powder solubilized in an aqueous acidic solution, processed to form a high pH hydrated chitosan gel precipitate material that is then neutralized by water washing and re-solubilized substantially to chitosan solution using carbonic acid. Chitosan materials can be mixed in solution with one or more of other hydrophilic polymers to create compositional heterogeneity and pharmaceutical agents to achieve controlled release of the agent(s) from the final forms at the site of application.
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公开(公告)号：US09925310B2
公开(公告)日：2018-03-27
申请号：US15371010
申请日：2016-12-06
发明人： Barbara McGrath , Simon McCarthy , Sam Kuhn , Alysha Wold , Michael Stolten , Amanda Bennett
CPC分类号： A61L27/58 , A61K9/0024 , A61K47/36 , A61K49/0008 , A61L27/20 , A61L27/26 , A61L2400/04 , C08B37/003 , C08L5/08 , C08L89/06 , C08L2201/06 , G01N33/5014 , G01N33/6869 , G01N2333/545 , G01N2400/28
摘要： The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
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公开(公告)号：US09846163B2
公开(公告)日：2017-12-19
申请号：US14638770
申请日：2015-03-04
发明人： Barbara McGrath , Simon McCarthy , Sam Kuhn , Alysha Wold , Michael Stolten , Amanda Bennett
CPC分类号： A61L27/58 , A61K9/0024 , A61K47/36 , A61K49/0008 , A61L27/20 , A61L27/26 , A61L2400/04 , C08B37/003 , C08L5/08 , C08L89/06 , C08L2201/06 , G01N33/5014 , G01N33/6869 , G01N2333/545 , G01N2400/28
摘要： The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
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公开(公告)号：US20240216571A1
公开(公告)日：2024-07-04
申请号：US18415412
申请日：2024-01-17
发明人： Brian Clare , Radim Dvorák , Simon McCarthy , Jirí Machát
IPC分类号： A61L15/28 , A61L15/42 , A61L24/00 , A61L24/08 , A61L27/20 , A61L27/50 , A61L27/56 , D01D1/02 , D01D5/08 , D01D5/084 , D01D5/18 , D01D10/02 , D01F1/02 , D01F9/00
CPC分类号： A61L15/28 , A61L15/425 , A61L24/0036 , A61L24/08 , A61L27/20 , A61L27/50 , A61L27/56 , D01D5/08 , D01D5/084 , D01D5/18 , D01F9/00 , A61L2400/04 , A61L2430/00 , D01D1/02 , D01D10/02 , D01F1/02
摘要： The present chitosan-based superfine fiber invention relates to compositions, formulations, and processes that result in numerous significant advantages for the production and use of superfine fiber bioactive matrices in biomedical applications. The present invention relates to superfine, chitosan-based fibers, wherein the chitosan-based fibers have a percentage chitosan content of at least about 20% w/w, and highly conformable and compliant matrices comprising such fibers, processes for their production, and related formulations. The superfine chitosan-based fibers of the invention preferably include microfibers with diameter less than or equal to about 10 microns and micron and submicron fibers that are about 2 microns and less.
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公开(公告)号：US11890384B2
公开(公告)日：2024-02-06
申请号：US15431168
申请日：2017-02-13
IPC分类号： A61L15/28 , A61L15/42 , D01D5/18 , A61L27/50 , A61L27/56 , A61L24/08 , A61L27/20 , A61L24/00 , D01F9/00 , D01D5/08 , D01D5/084 , D01F1/02 , D01D10/02 , D01D1/02
CPC分类号： A61L15/28 , A61L15/425 , A61L24/0036 , A61L24/08 , A61L27/20 , A61L27/50 , A61L27/56 , D01D5/08 , D01D5/084 , D01D5/18 , D01F9/00 , A61L2400/04 , A61L2430/00 , D01D1/02 , D01D10/02 , D01F1/02 , A61L15/28 , C08L5/08 , A61L24/08 , C08L5/08 , A61L27/20 , C08L5/08
摘要： The present chitosan-based superfine fiber invention relates to compositions, formulations, and processes that result in numerous significant advantages for the production and use of superfine fiber bioactive matrices in biomedical applications. The present invention relates to superfine, chitosan-based fibers, wherein the chitosan-based fibers have a percentage chitosan content of at least about 20% w/w, and highly conformable and compliant matrices comprising such fibers, processes for their production, and related formulations. The superfine chitosan-based fibers of the invention preferably include microfibers with diameter less than or equal to about 10 microns and micron and submicron fibers that are about 2 microns and less.
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