公开(公告)号：US20060079536A1

公开(公告)日：2006-04-13

申请号：US10525158

申请日：2003-08-21

申请人： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Gyorkos ,  Scott Pratt ,  Christopher Corrette

发明人： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Gyorkos ,  Scott Pratt ,  Christopher Corrette

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： C07D487/04

摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.

摘要翻译： 提供了包含式（I）化合物的钙受体调节剂：其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X 1是CR 1，CR 1，R 2，N或NR 13， ; X 2是N或NR 3; Y是C，CR 4或N，Z是CR 5，CR 5，R 6，N或NR 7 ; Ar是任选取代的环状基团; R为H，任选取代的烃基等; “img id =”custom-character-00001“he =”1.78mm“wi =”2.12mm“file =”US20060079536A1-20060413-P00001.TIF“alt =”custom character“img-content =”character“img- format =“tif”/>是单键或双键; R 1，R 2，R 3，R 4，R 5， R 6，R 7和R 13独立地是H，任选取代的烃基; 或其盐或其前药。 式（II）和（III）的化合物：其中环A是任选取代的5-至7-元环; Q是C，CR 5或N; R 9，R 9，R 10，R 11和R 12都是 还可以提供H，任选取代的烃基等，或其盐。 还可以在式（II）中指定X 1，R 3，R 3，R 3，Y和X 3，和（ III）。

公开(公告)号：US20090215746A1

公开(公告)日：2009-08-27

申请号：US12263426

申请日：2008-10-31

申请人： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Charles Gyorkos ,  Scott Alan Pratt ,  Christopher Peter Corrette

发明人： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Charles Gyorkos ,  Scott Alan Pratt ,  Christopher Peter Corrette

IPC分类号： A61K31/519 ,  A61K31/55 ,  A61K31/541 ,  A61K31/5377 ,  C07D487/10 ,  C07D487/04 ,  A61P19/00

CPC分类号： C07D487/04

摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided.Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.

摘要翻译： 提供了包含式（I）化合物的钙受体调节剂：其中环A是任选取代的5至7元环; 环B是任选取代的5-至7-元杂环; X1是CR1，CR1R2，N或NR13; X2是N或NR3; Y为C，CR4或N，Z为CR5，CR5R6，N或NR7; Ar是任选取代的环状基团; R为H，任选取代的烃基等; ＆lt; img id =“CUSTOM-CHARACTER-00001”he =“3.13mm”wi =“8.47mm”file =“US20090215746A1-20090827-P00001.TIF”img-content =“character”img-format =“tif”/ >是单键或双键; R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 13独立地为H，任选取代的烃基; 或其盐或其前药。 式（II）和（III）的化合物：其中环A是任选取代的5-至7-元环; Q为C，CR5或N; R8，R9，R10，R11和R12独立地为氢，任选取代的烃基等，或其盐。 也如前所述，在式（II）和（III）中指定X1，R3，R1，Y和X3。

公开(公告)号：US07514441B2

公开(公告)日：2009-04-07

申请号：US10525158

申请日：2003-08-21

申请人： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Charles Gyorkos ,  Scott Alan Pratt ,  Christopher Peter Corrette

发明人： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Charles Gyorkos ,  Scott Alan Pratt ,  Christopher Peter Corrette

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P19/08 ,  A61P19/10

CPC分类号： C07D487/04

摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and  is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.

摘要翻译： 提供了包含式（I）化合物的钙受体调节剂：其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X1是CR1，CR1R2，N或NR13; X2是N或NR3; Y为C，CR4或N，Z为CR5，CR5R6，N或NR7; Ar是任选取代的环状基团; R为H，任选取代的烃基等; “=”1.78mm“wi =”3.89mm“file =”US07514441-20090407-P00001.TIF“alt =”自定义字符“img-content =”character“img- format =“tif”/>是单键或双键; R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 13独立地为H，任选取代的烃基; 或其盐或其前药。 式（II）和（III）的化合物：其中环A是任选取代的5-至7-元环; Q为C，CR5或N; R8，R9，R10，R11和R12独立地为氢，任选取代的烃基等，或其盐。 也如前所述，在式（II）和（III）中指定X1，R3，R1，Y和X3。

公开(公告)号：US06552054B1

公开(公告)日：2003-04-22

申请号：US10070150

申请日：2002-03-01

申请人： Tsuneo Yasuma ,  Masahiro Kawase ,  Akira Mori

发明人： Tsuneo Yasuma ,  Masahiro Kawase ,  Akira Mori

IPC分类号： A61K31425

CPC分类号： C07D405/12 ,  C07D311/24 ,  C07D413/12 ,  C07D417/12 ,  C07D493/04

摘要： The invention provides chromone derivatives of the following general formula, a process for preparing such chromone derivatives and a prophylactic and therapeutic agent comprising such chromone derivatives for bone diseases and chondropathy: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 is a hydrogen atom or hydrocarbon group; R3 is a hydrogen atom, hydrocarbon group or halogen; n is an integer of 0-3; or a salt thereof.

摘要翻译： 本发明提供以下通式的色酮衍生物，这种色酮衍生物的制备方法和包含骨疾病和软骨病的色酮衍生物的预防和治疗剂：其中环A为任选取代的苯环; R1是任选取代的非芳族杂环基; R2是氢原子或烃基; R3是氢原子，烃基或卤素; n为0-3的整数; 或其盐。

公开(公告)号：US06355672B1

公开(公告)日：2002-03-12

申请号：US09744857

申请日：2001-01-30

申请人： Tsuneo Yasuma ,  Haruhiko Makino ,  Akira Mori

发明人： Tsuneo Yasuma ,  Haruhiko Makino ,  Akira Mori

IPC分类号： C07D33708

CPC分类号： C07D263/44 ,  C07D211/88 ,  C07D233/74 ,  C07D277/04 ,  C07D295/135 ,  C07D495/04

摘要： The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

摘要翻译： 本发明提供下式的化合物：其中环A是任选取代的苯环; R1是任选取代的非芳族杂环基; R2和R3独立地为氢原子或任选取代的烃基; n为0-3的整数; 或其盐，其可用作具有成骨促进作用的药物和软骨素促进作用。本发明涉及具有抑制淀粉样蛋白b蛋白的产生和/或分泌的优异效果的胺化合物及其制备和用途。 特别地，对于预防和/或治疗例如神经变性疾病，淀粉样血管病，由脑血管障碍引起的神经障碍等是有效的。

公开(公告)号：US06531604B2

公开(公告)日：2003-03-11

申请号：US10044787

申请日：2002-01-11

申请人： Tsuneo Yasuma ,  Haruhiko Makino ,  Akira Mori

发明人： Tsuneo Yasuma ,  Haruhiko Makino ,  Akira Mori

IPC分类号： C07D21140

CPC分类号： C07D263/44 ,  C07D211/88 ,  C07D233/74 ,  C07D277/04 ,  C07D295/135 ,  C07D495/04

摘要： The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

摘要翻译： 本发明提供下式的化合物：其中环A是任选取代的苯环; R1是任选取代的非芳族杂环基; R2和R3独立地为氢原子或任选取代的烃基; n为0-3的整数; 或其盐，其可用作具有成骨促进作用的药物和软骨素促进作用。本发明涉及具有抑制淀粉样蛋白b蛋白的产生和/或分泌的优异效果的胺化合物及其制备和用途。 特别地，对于预防和/或治疗例如神经变性疾病，淀粉样血管病，由脑血管障碍引起的神经障碍等是有效的。

公开(公告)号：US09003884B2

公开(公告)日：2015-04-14

申请号：US13569209

申请日：2012-08-08

申请人： Yoshitaka Kato ,  Akira Mori ,  Makoto Narita ,  Yoshihiko Koizumi

发明人： Yoshitaka Kato ,  Akira Mori ,  Makoto Narita ,  Yoshihiko Koizumi

IPC分类号： G01C19/56 ,  G01C19/5776

CPC分类号： G01C19/5776

摘要： An oscillation type inertia force sensor includes an oscillator, an oscillation circuit unit, and a detection circuit unit. The oscillation circuit unit functions as a self oscillation circuit of a closed loop with the oscillator as a resonant element, and includes an AGC circuit. The AGC circuit includes a VGA circuit, a comparison circuit comparing a predetermined reference voltage with a voltage of the monitor signal to output a control signal based on the compared result, and a pulse width modulation circuit modulating the control signal to a pulse width modulation signal. Based on the pulse width modulation signal, the driving signal is modulated with the output of the VGA circuit switched between an ON state and OFF state to control the degree of the amplification factor of the VGA circuit.

摘要翻译： 振荡型惯性力传感器包括振荡器，振荡电路单元和检测电路单元。 振荡电路单元用作振荡器作为谐振元件的闭环的自振荡电路，并且包括AGC电路。 AGC电路包括VGA电路，将预定参考电压与监视信号的电压进行比较的比较电路，基于比较结果输出控制信号;以及脉宽调制电路，将控制信号调制为脉宽调制信号 。 基于脉宽调制信号，驱动信号被调制，VGA电路的输出在ON状态和OFF状态之间切换，以控制VGA电路的放大系数的程度。

公开(公告)号：US20120021195A1

公开(公告)日：2012-01-26

申请号：US13260543

申请日：2010-03-23

申请人： Shinji Hashiguchi ,  Kazutaka Hirano ,  Akira Mori

发明人： Shinji Hashiguchi ,  Kazutaka Hirano ,  Akira Mori

IPC分类号： B32B7/02 ,  C23C16/30 ,  C23C16/04 ,  B32B19/00

CPC分类号： G02B1/02 ,  C04B41/009 ,  C04B41/5011 ,  C04B41/85 ,  C04B2111/805 ,  G02B1/11 ,  G02B1/113 ,  Y10T428/24942 ,  C04B35/01 ,  C04B35/10 ,  C04B35/44 ,  C04B41/4529 ,  C04B41/4556

摘要： An optical member produced from a ceramic in which transparency in each wavelength region can be selectively improved, and a process for producing the optical member. The optical member is obtained by bringing a treatment gas comprising a fluorine atom into contact with an optical material comprising a specific ceramic under conditions according to the specific ceramic to thereby from a fluorinated film capable of improving the transmittance of light having wavelengths in a specific region, on at least some of the surface of the optical material.

摘要翻译： 可以选择性地提高由各波长范围的透明度的陶瓷制成的光学部件，以及光学部件的制造方法。 光学部件是通过使包含氟原子的处理气体与特定陶瓷的光学材料在根据特定陶瓷的条件下接触而得到的，从而可以提高能够提高具有特定区域的波长的光的透射率的氟化膜 在光学材料的至少一些表面上。

公开(公告)号：US07421106B2

公开(公告)日：2008-09-02

申请号：US11987707

申请日：2007-12-04

申请人： Akira Mori ,  Muneharu Nakabayashi

发明人： Akira Mori ,  Muneharu Nakabayashi

IPC分类号： G06K9/00

CPC分类号： G07D7/187 ,  G07D7/164 ,  G07D7/183

摘要： A technology that increases bill discrimination precision, wherein a bill discriminating apparatus detects the thickness distribution of a bill P that is subject to discrimination, and by comparing this thickness distribution data and the reference thickness distribution data that shows the thickness distribution of an authentic note held in advance, performs discrimination processing that includes double feed detection, tape detection, and authenticity discrimination. Then, authenticity discrimination is performed on areas for which the difference between the thickness distribution data and the reference thickness data is within a specified range.

摘要翻译： 一种提高纸币辨别精度的技术，其中纸币识别装置检测被鉴别的纸币P的厚度分布，并且通过比较该厚度分布数据和示出保持的真实纸币的厚度分布的参考厚度分布数据 提前执行包括双进纸检测，带检测和真实性鉴别的鉴别处理。 然后，对厚度分布数据和基准厚度数据之间的差在规定范围内的区域进行真伪判别。

公开(公告)号：US07353705B2

公开(公告)日：2008-04-08

申请号：US11682990

申请日：2007-03-07

申请人： Akira Mori ,  Iku Nagai ,  Kazushige Sawada ,  Makoto Narita

发明人： Akira Mori ,  Iku Nagai ,  Kazushige Sawada ,  Makoto Narita

IPC分类号： G01P9/04 ,  G01P19/56

CPC分类号： G01C19/5776

摘要： The oscillation type inertial force sensor includes an oscillator arranged to detect an inertial force, an oscillation circuit unit arranged to drive the oscillator, and a signal processing circuit unit arranged to generate a signal according to the magnitude of the inertial force on the basis of a detection output of the oscillator, and further includes a holding arranged to hold a processed signal in the signal processing circuit unit at a predetermined potential during a period immediately after power-on until operation of the oscillation circuit unit becomes stable in response to power-on.

摘要翻译： 振荡型惯性力传感器包括：检测惯性力的振荡器;驱动振荡器的振荡电路单元;以及信号处理电路单元，被配置为根据惯性力的大小生成信号 振荡器的检测输出，并且还包括保持器，其布置成在紧接着上电之后的周期期间将信号处理电路单元中的处理信号保持在预定电位，直到振荡电路单元的操作响应于上电而变得稳定 。