公开(公告)号：US20120328675A1

公开(公告)日：2012-12-27

申请号：US13582689

申请日：2011-03-03

申请人： Tsutomu Awamura ,  Hisanobu Nishikawa ,  Kazuhiko Kokaji ,  Akihiro Ishise ,  Takayuki Arai ,  Seiji Miura ,  Toshio Inagi

发明人： Tsutomu Awamura ,  Hisanobu Nishikawa ,  Kazuhiko Kokaji ,  Akihiro Ishise ,  Takayuki Arai ,  Seiji Miura ,  Toshio Inagi

IPC分类号： A61K9/00 ,  A61P1/12 ,  A61K31/426 ,  A61P29/00 ,  A61K31/47 ,  A61P3/06 ,  A61K31/451 ,  A61K31/192

CPC分类号： A61K31/045 ,  A61K9/006

摘要： Provided is a film preparation in which an unpleasant taste derived from a medicament is masked. The film preparation includes coating layers containing no terpene formed on both sides of a medicament-containing layer containing a medicament having an unpleasant taste and a terpene.

摘要翻译： 提供了一种其中掩盖衍生自药物的不愉快味道的膜制剂。 膜制剂包括不含萜烯的包衣层，其含有含有不愉快味道的药物和萜烯的药物含有层的两侧。

公开(公告)号：US20110159058A1

公开(公告)日：2011-06-30

申请号：US13060707

申请日：2009-08-25

申请人： Tsutomu Awamura ,  Hisanobu Nishikawa ,  Toshio Inagi

发明人： Tsutomu Awamura ,  Hisanobu Nishikawa ,  Toshio Inagi

IPC分类号： A61K9/70 ,  A61K31/451 ,  A61P1/12 ,  B32B37/02

CPC分类号： A61K31/451 ,  A61K9/0056 ,  A61K9/7007 ,  A61K31/045 ,  Y10T156/10

摘要： The film preparation of the present invention includes: a drug-containing intermediate layer containing loperamide hydrochloride, a terpene and a film-forming agent; and coating layers containing a film-forming agent and a plasticizer (but not a terpene) and laminated on both sides of the drug-containing intermediate layer. As a bitter taste derived from loperamide hydrochloride is thereby masked, uncomfortable sensation when taking the film preparation can be reduced. Furthermore, as this film preparation is rapidly dissolved (i.e., has a rapidly dissolving property) only with moisture in the oral cavity, it begins to work quickly and is very convenient when it is carried and taken.

摘要翻译： 本发明的膜制剂包括：含有盐酸洛哌丁胺，萜烯和成膜剂的含药中间层; 以及含有成膜剂和增塑剂（但不是萜烯）并层压在含药物中间层两侧的涂层。 由于盐酸洛哌丁胺衍生的苦味因此被掩蔽，因此可以降低制膜时的不适感。 此外，由于这种膜制剂仅在口腔内的水分迅速溶解（即具有快速溶解性），所以它开始快速起作用，并且在携带和服用时非常方便。