Intracellular Drug Delivery Improving Liposome
    2.
    发明申请
    Intracellular Drug Delivery Improving Liposome 审中-公开
    细胞内药物递送改善脂质体

    公开(公告)号:US20070286898A1

    公开(公告)日:2007-12-13

    申请号:US11661431

    申请日:2005-08-30

    IPC分类号: A61K9/127 A61K47/32

    CPC分类号: A61K9/1271 A61K9/0019

    摘要: [Problem] To provide a drug delivery system which is retained in the blood circulation and improves pharmacological effect of the drug in the target organ and cell. [Means for Resolution] A drug-containing liposome for use in the treatment with a liposome prepared by employing polyethylene glycol cholesteryl ether as a part of the liposome-forming agent and using said liposome-forming agent. It is possible to obtain excellent drug effect by further employing a polyethylene glycol diacylglycerol ester as a part of the liposome-forming agent.

    摘要翻译: [问题]提供保留在血液循环中的药物递送系统,并且改善药物在靶器官和细胞中的药理作用。 [解决方法]使用通过使用聚乙二醇胆固醇醚作为脂质体形成剂的一部分并使用所述脂质体形成剂制备的用于用脂质体处理的药物含脂质体。 通过进一步使用聚乙二醇二酰基甘油酯作为脂质体形成剂的一部分,可以获得优异的药物效果。