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    Water-insoluble medicine
    5.
    发明授权
    Water-insoluble medicine 失效
    水不溶性药

    公开(公告)号：US08399024B2

    公开(公告)日：2013-03-19

    申请号：US12879413

    申请日：2010-09-10

    申请人： Hiroyuki Kato ,  Isao Umeda ,  Kazuo Watanabe ,  Kazuya Hirata ,  Akio Ishiguro ,  Tetsu Go

    发明人： Hiroyuki Kato ,  Isao Umeda ,  Kazuo Watanabe ,  Kazuya Hirata ,  Akio Ishiguro ,  Tetsu Go

    IPC分类号： A61K9/14 ,  A61K31/44 ,  A61K9/127 ,  C21C1/00

    CPC分类号： A61K9/146 ,  A61K9/5161 ,  A61K31/44

    摘要： A method of producing water-insoluble anti-cancer drug in the form of particulates, the method including preparing a water-insoluble anti-cancer drug having at least one multiple bond in the structure, and irradiating said water-insoluble anti-cancer drug with a laser beam having a wavelength of a low absorption portion in the vicinity of the foot of an absorption curve on the long wavelength side within the absorption band until said water-insoluble anti-cancer drug is formed into particulates having an average particle diameter of 50 to 200 nm.

    摘要翻译： 一种以微粒形式生产不溶于水的抗癌药物的方法，该方法包括制备结构中具有至少一个多重键的水不溶性抗癌药物，并将所述水不溶性抗癌药物与 在吸收带内的长波长侧的吸收曲线的脚附近具有低吸收部分的波长的激光束，直到所述水不溶性抗癌药物形成具有平均粒径为50微米的颗粒 至200nm。

    WATER-INSOLUBLE MEDICINE
    7.
    发明申请
    WATER-INSOLUBLE MEDICINE 失效
    水不溶性药物

    公开(公告)号：US20110059183A1

    公开(公告)日：2011-03-10

    申请号：US12879413

    申请日：2010-09-10

    申请人： Hiroyuki KATO ,  Isao Umeda ,  Kazuo Watanabe ,  Kazuya Hirata ,  Akio Ishiguro ,  Tetsu Go

    发明人： Hiroyuki KATO ,  Isao Umeda ,  Kazuo Watanabe ,  Kazuya Hirata ,  Akio Ishiguro ,  Tetsu Go

    IPC分类号： A61K9/14 ,  A61K31/475 ,  A61K31/36 ,  A61P35/00 ,  B29B9/00

    CPC分类号： A61K9/146 ,  A61K9/5161 ,  A61K31/44

    摘要： A method of producing water-insoluble anti-cancer drug in the form of particulates, the method including preparing a water-insoluble anti-cancer drug having at least one multiple bond in the structure, and irradiating said water-insoluble anti-cancer drug with a laser beam having a wavelength of a low absorption portion in the vicinity of the foot of an absorption curve on the long wavelength side within the absorption band until said water-insoluble anti-cancer drug is formed into particulates having an average particle diameter of 50 to 200 nm.

    摘要翻译： 一种以微粒形式生产不溶于水的抗癌药物的方法，该方法包括制备结构中具有至少一个多重键的水不溶性抗癌药物，并将所述水不溶性抗癌药物与 在吸收带内的长波长侧的吸收曲线的脚附近具有低吸收部分的波长的激光束，直到所述水不溶性抗癌药物形成具有平均粒径为50微米的颗粒 至200nm。

    APPARATUS AND METHOD FOR COATING PARTICLES
    8.
    发明申请
    APPARATUS AND METHOD FOR COATING PARTICLES 审中-公开
    用于涂覆颗粒的装置和方法

    公开(公告)号：US20090226608A1

    公开(公告)日：2009-09-10

    申请号：US12300568

    申请日：2007-05-15

    申请人： Hiroyuki Kato ,  Isao Umeda ,  Kazuya Hirata

    发明人： Hiroyuki Kato ,  Isao Umeda ,  Kazuya Hirata

    IPC分类号： B05D7/24 ,  B05C3/04

    CPC分类号： B01J2/006 ,  B01J13/04

    摘要： An apparatus for coating particles with a polymer electrolyte, which includes at least one polymer membrane shell-coating part, the particles being coated with a membrane shell in the at least one polymer membrane shell-coating part by performing a step including contacting the particles having a predetermined charge with the polymer electrolyte having a charge opposite to that of the outer surface of the particles, thereby forming a membrane shell on the surface of the outermost layer of the particles.

    摘要翻译： 一种用聚合物电解质涂覆颗粒的装置，其包括至少一个聚合物膜外壳涂覆部分，所述颗粒在所述至少一个聚合物膜外壳涂覆部分中被膜壳涂覆，所述方法包括使具有 与聚合物电解质的预定电荷具有与颗粒的外表面的电荷相反的电荷，从而在颗粒的最外层的表面上形成膜壳。

    Preventive or Therapeutic Agents for Pancreatic Cancer, Ovarian Cancer, or Liver Cancer Comprising a Novel Water-Soluble Prodrug
    10.
    发明申请
    Preventive or Therapeutic Agents for Pancreatic Cancer, Ovarian Cancer, or Liver Cancer Comprising a Novel Water-Soluble Prodrug 审中-公开
    包含新型水溶性前体药物的胰腺癌，卵巢癌或肝癌的预防或治疗剂

    公开(公告)号：US20090118271A1

    公开(公告)日：2009-05-07

    申请号：US12083831

    申请日：2006-10-19

    申请人： Isao Umeda ,  Jun Ohwada ,  Sawako Ozawa ,  Mika Endo ,  Masako Ura

    发明人： Isao Umeda ,  Jun Ohwada ,  Sawako Ozawa ,  Mika Endo ,  Masako Ura

    IPC分类号： A61K31/5377 ,  C07D491/22 ,  A61K31/519 ,  A61P35/00 ,  A61K31/4375

    CPC分类号： C07D491/22 ,  A61K31/519

    摘要： Preventive or therapeutic agents for pancreatic cancer, ovarian cancer, or liver cancer of the present invention comprise a water-soluble prodrug represented by formula 1 described below, or a pharmaceutically acceptable salt, or a hydrate or solvate of the prodrug or pharmaceutically acceptable salt, (wherein, R1 represents a hydrogen atom, or a C1-C6 alkyl group; W represents a divalent group comprising a tertiary amino group or a divalent group comprising a sulfonyl group, and Y represents a residue of a compound represented by Y—OH comprising an alcoholic hydroxyl group, wherein said Y—OH is a camptothecin, a taxane, or an anticancer nucleotide).

    摘要翻译： 本发明的胰腺癌，卵巢癌或肝癌的预防或治疗剂包含由下述式1表示的水溶性前药或其前药或药学上可接受的盐的药学上可接受的盐或水合物或溶剂合物， （其中，R1表示氢原子或C1-C6烷基; W表示包含叔氨基或包含磺酰基的二价基团的二价基团，Y表示由Y-OH表示的化合物的残基，包括 醇羟基，其中所述Y-OH是喜树碱，紫杉烷或抗癌核苷酸）。