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公开(公告)号：US11944717B2
公开(公告)日：2024-04-02
申请号：US17477947
申请日：2021-09-17
IPC分类号： A61B17/11 , A61B17/00 , A61F2/00 , A61F2/02 , A61K9/00 , A61L27/18 , A61L27/26 , A61L27/52 , A61L31/14
CPC分类号： A61L27/26 , A61B17/1128 , A61F2/00 , A61F2/02 , A61K9/0004 , A61L27/18 , A61L27/52 , A61L31/14 , A61B2017/00526 , A61F2210/00 , A61F2210/008 , A61F2240/00 , A61F2240/001 , A61F2250/00 , A61L2400/06 , A61L2430/32
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.
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公开(公告)号：US11890393B2
公开(公告)日：2024-02-06
申请号：US17138703
申请日：2020-12-30
IPC分类号： A61B17/11 , A61F2/00 , A61F2/02 , A61K9/00 , A61L27/52 , A61L31/14 , A61B17/00 , A61L27/26 , A61L27/18
CPC分类号： A61L27/26 , A61B17/1128 , A61F2/00 , A61F2/02 , A61K9/0004 , A61L27/18 , A61L27/52 , A61L31/14 , A61B2017/00526 , A61F2210/00 , A61F2210/008 , A61F2240/00 , A61F2240/001 , A61F2250/00 , A61L2400/06 , A61L2430/32
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.
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公开(公告)号：US20220054705A1
公开(公告)日：2022-02-24
申请号：US17477947
申请日：2021-09-17
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth
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公开(公告)号：US20240238480A1
公开(公告)日：2024-07-18
申请号：US18617246
申请日：2024-03-26
发明人： Corinne BRIGHT , Yong REN , Kenneth M. Martin
IPC分类号： A61L27/26 , A61B17/00 , A61B17/11 , A61F2/00 , A61F2/02 , A61K9/00 , A61L27/18 , A61L27/52 , A61L31/14
CPC分类号： A61L27/26 , A61B17/1128 , A61F2/00 , A61F2/02 , A61K9/0004 , A61L27/18 , A61L27/52 , A61L31/14 , A61B2017/00526 , A61F2210/00 , A61F2210/008 , A61F2240/00 , A61F2240/001 , A61F2250/00 , A61L2400/06 , A61L2430/32
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.
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公开(公告)号：US20220096711A1
公开(公告)日：2022-03-31
申请号：US17547583
申请日：2021-12-10
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth
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