公开(公告)号：US20240100189A1

公开(公告)日：2024-03-28

申请号：US17930298

申请日：2022-09-07

申请人： Twister Biotech, Inc ,  Baylor College of Medicine

发明人： E. Lynn ZECHIEDRICH ,  Lirio Milenka AREVALO-SOLIZ ,  Daniel James CATANESE, JR. ,  Jonathan Marcus FOGG ,  Christopher E. COKER

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K38/22 ,  C12N15/113

CPC分类号： A61K48/0066 ,  A61K38/1758 ,  A61K38/2221 ,  C12N15/1136

摘要： MiniVectors and compositions containing MiniVectors that target genes implicated in IPF selected from CDH11, STAT3, STAT6, FoxM1, MDM2, TGFβ, SMAD, PDGFA, or TLR4 and/or increase intracellular levels of reduced glutathione, relaxin, and p53, are provided, along with uses in the treatment of idiopathic pulmonary fibrosis.

公开(公告)号：US20230190955A1

公开(公告)日：2023-06-22

申请号：US18048267

申请日：2022-10-20

申请人： BAYLOR COLLEGE OF MEDICINE ,  TWISTER BIOTECH, INC

发明人： E. LYNN ZECHIEDRICH ,  LIRIO MILENKA AREVALO-SOLIZ ,  Daniel James CATANESE, JR. ,  Jonathan Marcus FOGG ,  Christopher E. COKER ,  SANDEEP AGARWAL

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K38/22

CPC分类号： A61K48/0016 ,  A61K38/1758 ,  A61K38/2221 ,  A61K48/0058

摘要： Compositions containing MiniVectors and gene therapy uses, including long term repeated gene therapy uses, to treat liver fibrosis or liver cancer.

公开(公告)号：US20240093226A1

公开(公告)日：2024-03-21

申请号：US17930652

申请日：2022-09-08

申请人： BAYLOR COLLEGE OF MEDICINE ,  TWISTER BIOTECH, LLC

发明人： E. Lynn ZECHIEDRICH ,  Jonathan Marcus FOGG ,  Lirio Milenka AREVALO-SOLIZ ,  Daniel James CATANESE ,  Christopher E. COKER

IPC分类号： C12N15/85 ,  C12N15/113

CPC分类号： C12N15/85 ,  C12N15/113

摘要： MiniVectors and compositions containing MiniVectors that are ultrapure, and methods of making and using ultrapure MiniVectors for gene therapy uses, including long term repeated gene therapy uses.