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    Method and System for Treating Cancer Cachexia
    4.
    发明申请
    Method and System for Treating Cancer Cachexia 审中-公开
    治疗癌症恶病质的方法和系统

    公开(公告)号：US20160339064A1

    公开(公告)日：2016-11-24

    申请号：US15228454

    申请日：2016-08-04

    申请人： Katherine Rose Kovarik ,  Joseph E. Kovarik

    发明人： Katherine Rose Kovarik ,  Joseph E. Kovarik

    IPC分类号： A61K35/74 ,  A61K31/58 ,  A61K9/00 ,  A61K38/17

    CPC分类号： A61K35/74 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K31/58 ,  A61K35/741 ,  A61K35/742 ,  A61K35/745 ,  A61K35/747 ,  A61K38/1758 ,  A61K39/35 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/00 ,  A61K2300/00

    摘要： Various embodiments of the present invention are directed to the field of Oncology, and in particular, embodiments directed to a method of ameliorating, treating, or preventing a malignancy in a human subject wherein the steps of the method assist or boost the immune system in eradicating cancerous cells. In certain embodiments, administration of beneficial bacteria to an individual's microbiome that have been modified so as to produce effective amounts of desired compositions, compounds, agents, e.g. tomatidine, p53 protein, etc., is employed to address cancerous conditions. In several embodiments, the administration of such beneficial bacteria and microbes to an individual's microbiome invokes either an active (or a passive) immune response to destroy, weaken or render less invasive certain cancerous cells, and preferably maintains muscle tissue to combat cancer cachexia.

    摘要翻译： 本发明的各种实施方案涉及肿瘤学领域，特别涉及一种改善，治疗或预防人类受试者恶性肿瘤的方法的实施方案，其中所述方法的步骤有助于或增强免疫系统的消除 癌细胞。 在某些实施方案中，将有益细菌施用于已经被修饰以产生有效量的所需组合物，化合物，试剂，例如细菌的个体的微生物组合物。 tomatidine，p53蛋白等用于治疗癌症。 在几个实施方案中，将这种有益细菌和微生物施用于个体的微生物组可调用活性（或被动）免疫应答以破坏，削弱或使侵入性较小的某些癌细胞，并优选维持肌肉组织以抵抗癌症恶病质。

    Compositions and methods for inhibiting cell senescence and hyperproliferative disorders
    6.
    发明申请
    Compositions and methods for inhibiting cell senescence and hyperproliferative disorders 审中-公开
    用于抑制细胞衰老和过度增殖性疾病的组合物和方法

    公开(公告)号：US20060160732A1

    公开(公告)日：2006-07-20

    申请号：US10961824

    申请日：2004-10-08

    申请人： Gary Aronson

    发明人： Gary Aronson

    IPC分类号： A61K38/16 ,  C12Q1/70 ,  C07H21/04 ,  C07K14/16

    CPC分类号： C12N9/1241 ,  A61K38/00 ,  A61K38/1758 ,  A61K38/45 ,  A61K47/645 ,  C07K14/005 ,  C07K14/4703 ,  C07K14/4736 ,  C07K2319/00 ,  C07K2319/03 ,  C12N2740/16322 ,  A61K2300/00

    摘要： The present disclosure provides compositions and methods for inhibiting cell and/or organismic senescence by treating conditions associated with aging and preventing undesirable cell proliferation. Compositions provided in the present disclosure include a transport agent attached to a therapeutic agent portion, wherein the transport agent portion has a role in transporting the composition across one or more biological membranes and the therapeutic agent portion prolongs cell life by effects on the proliferative capacity of a cell. In particular, the therapeutic agent includes a first region having telomerase activity and a second region having tumor suppressor activity.

    摘要翻译： 本公开提供通过治疗与衰老相关的病症并预防不期望的细胞增殖来抑制细胞和/或生物衰老的组合物和方法。 在本公开中提供的组合物包括连接到治疗剂部分的运输剂，其中所述运输剂部分具有通过一种或多种生物膜运输所述组合物的作用，并且所述治疗剂部分通过对增殖能力的影响延长细胞寿命 一个单元格 特别地，治疗剂包括具有端粒酶活性的第一区域和具有肿瘤抑制活性的第二区域。

    Calpain inhibitors and their applications
    7.
    发明授权
    Calpain inhibitors and their applications 失效
    钙蛋白酶抑制剂及其应用

    公开(公告)号：US07001770B1

    公开(公告)日：2006-02-21

    申请号：US09416735

    申请日：1999-10-13

    申请人： Isabella A. Atencio ,  Drake M. LaFace ,  Muralidhara Ramachandra ,  Paul W. Shabram

    发明人： Isabella A. Atencio ,  Drake M. LaFace ,  Muralidhara Ramachandra ,  Paul W. Shabram

    IPC分类号： C12N15/00 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

    CPC分类号： C12N15/86 ,  A61K38/1709 ,  A61K38/1758 ,  A61K45/06 ,  C12N2710/10332 ,  C12N2710/10343

    摘要： The present invention provides a method to enhance apoptosis in a cell by the administration of p53 in combination with a calpain inhibitor. The present invention provides a method of increasing the infectivity of a cell to a viral vector by treatment of the cell with a calpain inhibitor. the present invention further provides a method of enhancing transciption of a therapeutic transgene from the CMV promoter. The present invention also provides a method of suppress the in vivo CTL response to viral vectors by the use of calpain inhibitors. The present invention further provides a pharmaceutical formulations of p53 and a calpain inhibitor in a pharmaceutically acceptable carrier. The present invention provides a method of ablating neoplastic cells in a mammalian organism in vivo by the co-administration of a calpain inhibitor and p53. The present invention also provides a method of ablating neoplastic cells in a population of normal cells contaminated by said neoplastic cells ex vivo by the administration of a recombinant adenovirus in combination with a calpain inhibitor to said population.

    摘要翻译： 本发明提供了通过与钙蛋白酶抑制剂组合施用p53来增强细胞凋亡的方法。 本发明提供了通过用钙蛋白酶抑制剂处理细胞来增加细胞对病毒载体的感染性的方法。 本发明还提供了增强来自CMV启动子的治疗性转基因的转录的方法。 本发明还提供了通过使用钙蛋白酶抑制剂抑制对病毒载体的体内CTL应答的方法。 本发明进一步提供药学上可接受的载体中的p53和钙蛋白酶抑制剂的药物制剂。 本发明提供了通过共同给予钙蛋白酶抑制剂和p53来体内在哺乳动物生物体内消化肿瘤细胞的方法。 本发明还提供了一种通过将重组腺病毒与钙蛋白酶抑制剂组合给所述群体而在体外从所述赘生性细胞污染的正常细胞群体中消化肿瘤细胞的方法。