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公开(公告)号:US20120076752A1
公开(公告)日:2012-03-29
申请号:US13293357
申请日:2011-11-10
申请人: Tzyy-Choou WU , Chien-Fu Hung , Elizabeth JAFFEE , Ralph HRUBAN
发明人: Tzyy-Choou WU , Chien-Fu Hung , Elizabeth JAFFEE , Ralph HRUBAN
CPC分类号: A61K39/0208 , A01K2267/0331 , A61K39/0011 , A61K2039/505 , A61K2039/5154 , A61K2039/52 , A61K2039/522 , A61K2039/523 , A61K2039/53 , A61K2039/55511 , A61K2039/55522 , A61K2039/57 , A61K2039/6031 , C07K7/06 , C07K14/4748 , C07K16/30 , C12N15/74 , C12N15/8509 , C12N2710/16522 , C12N2740/13043 , Y02A50/484
摘要: Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.
摘要翻译: 间皮素可用作免疫治疗靶标。 它诱导细胞溶解性T细胞反应。 确定诱导这种反应的间皮素的部分。 疫苗可以是多核苷酸或基于多肽的。 提高溶细胞T细胞应答的载体包括细菌和病毒。 用于测试疫苗和其他抗肿瘤治疗剂和预防剂的小鼠模型包括强表达间皮素的转化的腹膜细胞系。