公开(公告)号：US20240360182A1

公开(公告)日：2024-10-31

申请号：US18768701

申请日：2024-07-10

申请人： The Trustees of the University of Pennsylvania ,  Inovio Pharmaceuticals, Inc.

发明人： David B. Weiner ,  Bernadette Ferraro ,  Jian Yan ,  Patricia A. Brown ,  Rodney A. Bowling ,  Douglas R. Kern ,  Mathura P. Ramanathan ,  Niranjan Y. Sardesai ,  Karuppiah Muthumani

IPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/135 ,  A61K39/39 ,  A61M37/00 ,  A61N1/32 ,  C12N7/00 ,  G01N33/569

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/135 ,  A61K39/39 ,  A61M37/00 ,  A61N1/327 ,  C12N7/00 ,  G01N33/56983 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/552 ,  C12N2770/32122 ,  C12N2770/32134 ,  G01N2333/09 ,  G01N2469/20

摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.

公开(公告)号：US20240325510A1

公开(公告)日：2024-10-03

申请号：US18668477

申请日：2024-05-20

申请人： EULJI UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION

发明人： Seung Hoon LEE ,  Yun Hee KANG ,  Myung Shin LEE ,  Seung Ro HAN

IPC分类号： A61K39/00 ,  A61P35/00 ,  C12N1/20 ,  C12N15/74 ,  C12R1/245 ,  C12R1/46

CPC分类号： A61K39/001111 ,  A61P35/00 ,  C12N1/205 ,  C12N15/746 ,  A61K2039/522 ,  A61K2039/523 ,  C12R2001/245 ,  C12R2001/46

摘要： The present invention provides an anti-cancer vaccine composition and method of vaccination using the same, which can effectively inhibit the development and growth of various cancers including colorectal cancer, by inducing vaccination through the expression of PD-L1 or PD-L1-T epitope proteins on the surface of strains of the genus Lactobacillus.

公开(公告)号：US12064472B2

公开(公告)日：2024-08-20

申请号：US18318909

申请日：2023-05-17

申请人： The United States of America, as represented by the Secretary of Agriculture

发明人： Adalberto A. Perez De Leon ,  Robert Miller ,  Robert E. Briggs ,  Fred M. Tatum ,  Felicito Guerrero

IPC分类号： A61K39/02 ,  A61K39/00 ,  A61K39/08 ,  A61P33/14 ,  C07K14/33 ,  C07K14/435

CPC分类号： A61K39/0003 ,  A61K39/08 ,  A61P33/14 ,  C07K14/33 ,  C07K14/43527 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/552 ,  C07K2319/00

摘要： This invention relates to novel fusion peptides and immunogenic compositions containing the fusion peptides useful in the control and prevention of tick infestations. The invention also relates to compositions comprising said fusion peptides, methods of vaccination against tick infestation using said fusion peptides and compositions, and kits for use with such compositions and methods.

公开(公告)号：US11969468B2

公开(公告)日：2024-04-30

申请号：US17291480

申请日：2019-11-04

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

发明人： Roy Curtiss, III

IPC分类号： A61K39/02 ,  A61K35/74 ,  A61K39/04 ,  A61K39/39 ,  A61P37/04 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K35/74 ,  A61K39/04 ,  A61P37/04 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/55594

摘要： Disclosed herein are unique adjuvant compositions comprising an attenuated derivative of a bacterial pathogen that undergoes lysis in vivo. In exemplary embodiments, the bacterial pathogen is a Salmonella spp. Also disclosed are methods for enhancing an immune response using the adjuvants disclosed herein.

公开(公告)号：US20240124540A1

公开(公告)日：2024-04-18

申请号：US18516360

申请日：2023-11-21

申请人： Advaxis, Inc.

发明人： Robert Petit ,  Michael F. Princiotta ,  Brandon Coder ,  David Balli

IPC分类号： C07K14/47 ,  A61K35/74 ,  A61K39/00 ,  C12N15/74

CPC分类号： C07K14/4748 ,  A61K35/74 ,  A61K39/0011 ,  A61K39/001103 ,  A61K39/001104 ,  A61K39/001107 ,  A61K39/00115 ,  A61K39/001157 ,  A61K39/001186 ,  A61K39/001188 ,  A61K39/001189 ,  A61K39/001194 ,  A61K39/001195 ,  C12N15/74 ,  A61K2039/523 ,  A61K2039/55544 ,  A61K2039/55594 ,  A61K2039/645 ,  C07K2319/43 ,  C07K2319/95

摘要： Provided herein are recombinant fusion polypeptides comprising one or more antigenic peptides (e.g., fused to a PEST-containing peptide) from cancer-associated proteins. The antigenic peptides can comprise one or more or all of an antigenic peptide comprising a recurrent cancer mutation, an antigenic peptide comprising a heteroclitic mutation, or an antigenic peptide fused to a ubiquitin protein. For example, provided herein are recombinant fusion polypeptides comprising two or more antigenic peptides (e.g., fused to a PEST-containing peptide), wherein each antigenic peptide comprises a recurrent cancer mutation, and wherein at least two of the antigenic peptides are fragments of the same cancer-associated protein. Also provided are nucleic acids encoding such fusion polypeptides, recombinant bacteria or Listeria strains comprising such fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such recombinant fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.

公开(公告)号：US11957746B2

公开(公告)日：2024-04-16

申请号：US16980785

申请日：2019-03-25

申请人： Boehringer Ingelheim Animal Health USA Inc.

发明人： Leigh Wilmes ,  Matthew Coons ,  Amanda Brown ,  Michael Johannes Gassel ,  Francois-Xavier Orveillon ,  Katharina Hedwig Toepfer ,  Elida Bautista ,  Kathy Schlesinger

IPC分类号： A61K39/12 ,  A61P31/20 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61P31/20 ,  C12N15/86 ,  A61K2039/523 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N2710/14034 ,  C12N2710/14042 ,  C12N2710/14062

摘要： The present invention in particular relates to a method of producing an immunogenic composition exhibiting reduced virucidal activity, as well as to the immunogenic composition and uses thereof, wherein the method in particular comprises the steps of: (a) providing a mixture with a first liquid and a recombinant protein, (b) concentrating the recombinant protein in the mixture by removing a portion of the first liquid from the mixture, and (c) processing the solution resulting from step (b) by continuous diafiltration.

公开(公告)号：US20240091342A1

公开(公告)日：2024-03-21

申请号：US18273036

申请日：2022-01-25

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  Kyoto University

发明人： Toshiro SHIRAKAWA ,  Shunpei UENO ,  Koichi KITAGAWA ,  Akihiko KONDO ,  Masanori KAMEOKA ,  Takane KATAYAMA

IPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005

CPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  A61K2039/523

摘要： Provided is an orally administrable vaccine against a coronavirus infectious disease. A transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium enables the provision of the orally administrable vaccine against a coronavirus infectious disease. The transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium can induce humoral immunity and cellular immunity through oral administration to suppress an increase in severity of pneumonia or the like even after viral infection.

公开(公告)号：US11932671B2

公开(公告)日：2024-03-19

申请号：US17245681

申请日：2021-04-30

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC分类号： A61P37/04 ,  A61K39/095 ,  C07K14/22 ,  A61K39/00

CPC分类号： C07K14/22 ,  A61K39/095 ,  A61K2039/523 ,  A61K2039/55511 ,  A61K2039/70

摘要： Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US11920139B2

公开(公告)日：2024-03-05

申请号：US17500940

申请日：2021-10-14

申请人： The Arizona Board of Regents for and on Behalf of Arizona State University ,  The Washington University

发明人： Roy Curtiss, III ,  Shifeng Wang ,  Soo-Young Wanda ,  Wei Kong

IPC分类号： C12Q1/68 ,  A61K35/74 ,  A61K39/00 ,  C12N1/36 ,  C12N15/74 ,  A61K35/00

CPC分类号： C12N15/74 ,  A61K35/74 ,  A61K39/00 ,  C12N1/36 ,  A61K2035/11 ,  A61K2039/522 ,  A61K2039/523

摘要： The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.

公开(公告)号：US11905517B2

公开(公告)日：2024-02-20

申请号：US16958170

申请日：2018-12-19

申请人： VEROVACCINES GMBH

发明人： Hans Caspar Hührlimann ,  Martina Behrens ,  Mandy Gebauer ,  Karin Breunig ,  Sven-Erik Behrens

IPC分类号： A61P31/14 ,  A61P31/16 ,  A61K39/12 ,  A61K39/145 ,  C12N15/81 ,  A61K9/00 ,  C12N1/16 ,  A61K39/00

CPC分类号： C12N15/815 ,  A61K9/006 ,  A61K9/0019 ,  A61K39/12 ,  A61K39/145 ,  A61P31/14 ,  A61P31/16 ,  C12N1/16 ,  A61K2039/523 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2720/10034 ,  C12N2760/16134 ,  C12N2770/24334

摘要： The invention relates to recombinant Kluyveromyces lactis (K. lactis) yeasts which are capable of the highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for generating a protective immune response against pathogens. The invention provides in particular K. lactis strains for the targeted cloning of foreign antigen-coding nucleic acids into the yeast genome of the K. lactis strain, which is characterized in that the K. lactis strain has integrated expression cassettes for foreign antigens as an alternative or in addition to the KILAC4 locus on the KIURA3-20 locus (KLLA0E22771g) and/or on the KIMET5-1 locus (KLLA0B03938g). The invention further relates to integrative expression vectors and to methods for producing the K. lactis strains of the invention as well as to the use thereof as vaccines.