公开(公告)号：US10124043B1

公开(公告)日：2018-11-13

申请号：US15896833

申请日：2018-02-14

Applicant: U.S. Army Edgewood Chemical Biological Center

Inventor： Steven P Harvey ,  Mark A Guelta ,  Leslie R McMahon

IPC: C12N9/16 ,  A61K38/46 ,  C07F9/14

Abstract: The invention comprises isolated, mutant, non-wild-type organophosphorus acid anhydrolase (OPAA) enzymes having three site mutations, methods of production, and methods of use to effectively degrade organophosphorus compound EA1356 (2-methylcyclohexyl methylphosphonofluoridate) with greater catalytic efficiency than the wild-type OPAA enzyme.

公开(公告)号：US10363289B1

公开(公告)日：2019-07-30

申请号：US15840412

申请日：2017-12-13

Applicant: U.S. Army Edgewood Chemical Biological Center

Inventor： Steven P. Harvey ,  Mark A Guelta ,  Leslie R McMahon

IPC: C12N9/16 ,  A61K38/46 ,  A62D3/02 ,  A61P43/00 ,  A62D101/02 ,  A62D101/04 ,  A62D101/26 ,  C07F9/14 ,  C12Q1/46

Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2, 2′-dimethylcyclopentyl methylphosphonofluoridate).

公开(公告)号：US10335465B1

公开(公告)日：2019-07-02

申请号：US15880747

申请日：2018-01-26

Applicant: U.S. Army Edgewood Chemical Biological Center

Inventor： Steven P Harvey ,  Melissa M Dixon ,  Mark A Guelta ,  Leslie R McMahon

IPC: C12N9/16 ,  A61K38/16 ,  A62D7/00 ,  A61K38/46 ,  A62D3/02 ,  A62D101/26 ,  A62D101/02

Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2′-dimethylcyclopentyl methylphosphonofluoridate).