公开(公告)号：US20200231664A1

公开(公告)日：2020-07-23

申请号：US16554510

申请日：2019-08-28

Applicant: UCB BIOPHARMA SPRL

Inventor： David G. Winkler ,  Jiye Shi ,  John Latham

IPC: C07K16/22 ,  G01N33/68 ,  C07K14/475 ,  A61K47/64 ,  C07K16/18 ,  C07K14/51

Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.