公开(公告)号：US20230271951A1

公开(公告)日：2023-08-31

申请号：US17995495

申请日：2021-04-06

申请人： UCB BIOPHARMA SRL

发明人： Prafulkumar Tulshibhai CHOVATIA ,  Anne Marie FOLEY ,  Gregory William HASLETT ,  Martin Clive HUTCHINGS ,  James Andrew JOHNSON ,  Fabien Claude LECOMTE ,  Nathaniel Julius Thomas MONCK ,  Joanna Rachel QUINCEY ,  Konstantinos RAMPALAKOS ,  James Thomas REUBERSON ,  Adam Peter SMALLEY ,  Giancarlo TRANI ,  Darshan Gunvant VAIDYA

IPC分类号： C07D413/14 ,  A61K45/06 ,  C07D403/14 ,  C07D413/12 ,  C07D471/04 ,  C07D235/24 ,  C07D403/12

CPC分类号： C07D413/14 ,  A61K45/06 ,  C07D235/24 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D471/04

摘要： A series of substituted 4,4-difluorocyclohexyl derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.