公开(公告)号：US20230074381A1

公开(公告)日：2023-03-09

申请号：US17804934

申请日：2022-06-01

Applicant: UCB Biopharma SRL

Inventor： Helene Margaret Finney ,  Alastair David Griffiths Lawson ,  Stevan Graham Shaw ,  Bryan John Smith ,  Kerry Louise Tyson ,  Lara Kevorkian ,  Christoph Meier ,  Kaushik Sarkar ,  Paul Alan Atherfold

IPC: C07K16/28 ,  G01N33/50 ,  G01N33/564 ,  G01N33/68 ,  A61K47/60 ,  A61K47/64 ,  A61K39/395

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

公开(公告)号：US11518803B2

公开(公告)日：2022-12-06

申请号：US16925281

申请日：2020-07-09

Applicant: UCB BIOPHARMA SRL

Inventor： Helene Bon ,  Joanne Elizabeth Compson ,  Kate Louise Dixon ,  Carl Brendan Doyle ,  Mark Ellis ,  Maria Margarida Gouveia Sancho ,  Raymond Anthony Jupp ,  Lara Kevorkian ,  Daniel John Lightwood ,  Diane Marshall ,  Andrew Charles Payne ,  Joseph Michael David Rastrick ,  Monika-Sarah Schulze ,  Alison Turner ,  Kerry Louise Tyson

IPC: C07K16/22 ,  A61P11/00 ,  A61K9/00 ,  A61P11/12 ,  A61K39/395

Abstract: The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.