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公开(公告)号：US12055549B2
公开(公告)日：2024-08-06
申请号：US17325036
申请日：2021-05-19
申请人： UCB Biopharma SRL , SANOFI
发明人： James Philip O'Connell , John Robert Porter , Alastair Lawson , Tracy Lynn Arakaki , Daniel John Lightwood , Rebecca Jayne Munro
IPC分类号： G01N33/68 , A61K47/64 , A61P35/00 , A61P37/00 , C07D213/72 , C07D235/04 , C07D239/26 , C07D401/14 , C07D471/00 , C07D471/04 , C07K14/525 , C07K14/705 , C07K16/24
CPC分类号： G01N33/6845 , A61K47/6425 , A61P35/00 , A61P37/00 , C07D213/72 , C07D235/04 , C07D239/26 , C07D401/14 , C07D471/00 , C07D471/04 , C07K14/525 , C07K14/70575 , C07K16/241 , G01N33/6854 , G01N33/6863 , C07K2317/55 , C07K2317/92 , G01N2333/525 , G01N2500/02
摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
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公开(公告)号：US11091542B2
公开(公告)日：2021-08-17
申请号：US16063133
申请日：2016-12-14
申请人： UCB BIOPHARMA SRL
发明人： Ralph Adams , Pallavi Bhatta , Emma Dave , Sam Philip Heywood , David Paul Humphreys , Diane Marshall , Daniel John Lightwood
摘要： The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：US11022614B2
公开(公告)日：2021-06-01
申请号：US15736558
申请日：2015-10-22
申请人： UCB BIOPHARMA SRL , SANOFI
发明人： James Philip O'Connell , John Robert Porter , Alastair Lawson , Tracy Lynn Arakaki , Daniel John Lightwood , Rebecca Jayne Munro
IPC分类号： C07K14/525 , C07K16/24 , G01N33/68 , C07D401/14 , C07D471/00 , C07K14/705 , C07D213/72 , C07D235/04 , C07D239/26 , C07D471/04 , A61K47/64 , A61P37/00 , A61P35/00
摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
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公开(公告)号：US20230084464A1
公开(公告)日：2023-03-16
申请号：US17787039
申请日：2020-12-18
申请人： UCB BIOPHARMA SRL
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing the antibody molecules.
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公开(公告)号：US11518803B2
公开(公告)日：2022-12-06
申请号：US16925281
申请日：2020-07-09
申请人： UCB BIOPHARMA SRL
发明人： Helene Bon , Joanne Elizabeth Compson , Kate Louise Dixon , Carl Brendan Doyle , Mark Ellis , Maria Margarida Gouveia Sancho , Raymond Anthony Jupp , Lara Kevorkian , Daniel John Lightwood , Diane Marshall , Andrew Charles Payne , Joseph Michael David Rastrick , Monika-Sarah Schulze , Alison Turner , Kerry Louise Tyson
IPC分类号： C07K16/22 , A61P11/00 , A61K9/00 , A61P11/12 , A61K39/395
摘要： The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.
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公开(公告)号：US11674967B2
公开(公告)日：2023-06-13
申请号：US17013326
申请日：2020-09-04
申请人： UCB BIOPHARMA SRL
发明人： James Philip O'Connell , John Robert Porter , Alastair Lawson , Boris Kroeplien , Stephen Edward Rapecki , Timothy John Norman , Graham John Warrellow , Tracy Lynn Arakaki , Alex Buntin Burgin , William Ross Pitt , Mark Daniel Calmiano , David Andreas Schubert , Daniel John Lightwood , Rebecca Jayne Munro
IPC分类号： G01N33/68 , C07D401/14 , C07K14/525 , C07D471/00 , C07K14/705 , C07K16/24 , C07D213/72 , C07D235/04 , C07D239/26 , C07D471/04 , A61K47/64 , A61P37/00 , A61P35/00
CPC分类号： G01N33/6845 , A61K47/6425 , A61P35/00 , A61P37/00 , C07D213/72 , C07D235/04 , C07D239/26 , C07D401/14 , C07D471/00 , C07D471/04 , C07K14/525 , C07K14/70575 , C07K16/241 , G01N33/6854 , G01N33/6863 , C07K2317/55 , C07K2317/92 , G01N2333/525 , G01N2500/02
摘要： A new, stable trimeric TNFα structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNFα/TNFR1 interaction. Membrane-bound TNFα is not affected in its ability to signal through TNFR2, and thus the new structure of TNFα may be used in therapies which do not significantly raise the risk of infection or malignancy.
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7.发明授权公开(公告)号：US10935553B2
公开(公告)日：2021-03-02
申请号：US15736535
申请日：2015-10-22
申请人： UCB Biopharma SRL
发明人： James Philip O'Connell , John Robert Porter , Alastair Lawson , Daniel John Lightwood , Rebecca Jayne Munro
IPC分类号： C07D401/14 , C07K14/525 , C07D471/00 , C07K14/705 , C07K16/24 , C07D213/72 , C07D235/04 , C07D239/26 , C07D471/04 , A61K47/64 , A61P37/00 , A61P35/00 , G01N33/68
摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
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公开(公告)号：US20230087378A1
公开(公告)日：2023-03-23
申请号：US17786996
申请日：2020-12-18
申请人： UCB BIOPHARMA SRL
发明人： Adnan Rahman Khan , Sam Philip Heywood , David Paul Humphreys , Daniel John Lightwood , Emma Dave , Emily Mary Cairistine Barry , Sarah Jayne Stanyon
摘要： The present invention relates to a multi-specific antibody having specificity for human IL-13, human IL-17A and/or human IL-17F. The invention further relates to methods for producing the multi-specific antibody and to its therapeutic use for the treatment of atopic dermatitis and other diseases.
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公开(公告)号：US11292831B2
公开(公告)日：2022-04-05
申请号：US16772043
申请日：2018-12-13
申请人： UCB Biopharma SRL
发明人： Patrick Downey , Kerry Louise Tyson , Marco Kriek , Lorenzo De Lichtervelde , Daniel John Lightwood , David James McMillan , Peter Charles Elliott , Terence Seward Baker
摘要： The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号：US11261242B2
公开(公告)日：2022-03-01
申请号：US16771993
申请日：2018-12-13
申请人： UCB Biopharma SRL
发明人： Ralph Adams , Patrick Downey , Terence Seward Baker , Kerry Louise Tyson , Lorenzo De Lichtervelde , Daniel John Lightwood , David James McMillan
摘要： The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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