公开(公告)号：US20200331960A1

公开(公告)日：2020-10-22

申请号：US16629609

申请日：2018-07-16

申请人： UCB BIOPHARMA SRL

发明人： MICHAEL HARRY ROSE

IPC分类号： C07K1/22 ,  B01D15/38 ,  B01D15/24 ,  B01D15/18 ,  C07K1/34

摘要： The present invention is in the field of purification and protein purification in particular. The invention provides improved techniques for the industrial-scale purification of proteins and other biomolecules. More specifically, it relates to a process for the purification of a compound of interest, such as a protein, preferably an antibody or an antibody fragment using a chromatography step, preferably a semi-continuous chromatography step.

公开(公告)号：US20210323999A1

公开(公告)日：2021-10-21

申请号：US17327865

申请日：2021-05-24

申请人： UCB BIOPHARMA SRL

发明人： MICHAEL HARRY ROSE

IPC分类号： C07K1/18 ,  C07K1/22 ,  C07K1/16

摘要： The present invention relates to a process for purification a protein comprising a semi-continuous chromatography step whereby the flow-through is collected and re-loaded onto the chromatography matrix.