公开(公告)号：US10105359B2

公开(公告)日：2018-10-23

申请号：US15517795

申请日：2015-10-06

申请人： UCB Biopharma SPRL

发明人： Anne Valade ,  Eric Jnoff ,  Ali Ates ,  Pierre Burssens ,  David Skolc ,  Zara Sands ,  Benoit Mathieu

IPC分类号： C07D217/06 ,  A61K31/4725 ,  C07D401/06 ,  C07D403/06 ,  C07D413/04

摘要： The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US20190106406A1

公开(公告)日：2019-04-11

申请号：US16086698

申请日：2017-04-07

申请人： UCB Biopharma SPRL

发明人： Ali Ates ,  Eric Jnoff ,  Laurent Provins ,  Anne Valade ,  Adrian Hall

IPC分类号： C07D401/06 ,  C07D471/04

CPC分类号： C07D401/06 ,  C07D217/06 ,  C07D403/06 ,  C07D471/04

摘要： The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), wherein G represents a fused heterocyclic system selected from the groups represented by formula (G1), (G2), (G3), (G4), (G5), and (G6), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US09975873B2

公开(公告)日：2018-05-22

申请号：US15517769

申请日：2015-10-06

申请人： UCB Biopharma SPRL

发明人： David Skolc ,  Ali Ates ,  Eric Jnoff ,  Anne Valade ,  Benoit Mathieu ,  Zara Sands

IPC分类号： C07D401/06 ,  A61K31/4035 ,  C07D209/44 ,  C07D487/04

CPC分类号： C07D401/06 ,  A61K31/4035 ,  C07D209/44 ,  C07D487/04

摘要： The present invention relates to isoindoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US20170313677A1

公开(公告)日：2017-11-02

申请号：US15517769

申请日：2015-10-06

申请人： UCB Biopharma SPRL

发明人： David Skolc ,  Ali Ates ,  Eric Jnoff ,  Anne Valade ,  Benoit Mathieu ,  Zara Sands

IPC分类号： C07D401/06 ,  C07D209/44 ,  C07D487/04 ,  A61K31/4035

CPC分类号： C07D401/06 ,  A61K31/4035 ,  C07D209/44 ,  C07D487/04

摘要： The present invention relates to isoindoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US10370355B2

公开(公告)日：2019-08-06

申请号：US16086698

申请日：2017-04-07

申请人： UCB Biopharma SPRL

发明人： Ali Ates ,  Eric Jnoff ,  Laurent Provins ,  Anne Valade ,  Adrian Hall

IPC分类号： C07D401/06 ,  C07D471/04

摘要： The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), wherein G represents a fused heterocyclic system selected from the groups represented by formula (G1), (G2), (G3), (G4), (G5), and (G6), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.