公开(公告)号：US20180022748A1

公开(公告)日：2018-01-25

申请号：US15547980

申请日：2016-01-29

申请人： UCB Biopharma SPRL

发明人： Joel Mercier ,  Laurent Provins ,  Celine Vermeiren ,  Yogesh Anil Sabnis

IPC分类号： C07D471/14 ,  A61K51/04 ,  C07B59/00

CPC分类号： C07D471/14 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07B59/002 ,  C07B2200/05

摘要： The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.

公开(公告)号：US12006316B2

公开(公告)日：2024-06-11

申请号：US17700075

申请日：2022-03-21

申请人： UCB Biopharma SPRL

发明人： Joel Mercier ,  Laurent Provins ,  Celine Vermeiren ,  Yogesh Anil Sabnis

IPC分类号： C07D471/14 ,  A61K31/437 ,  A61K51/04 ,  C07B59/00

CPC分类号： C07D471/14 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07B59/002 ,  C07B2200/05

摘要： The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.

公开(公告)号：US20190106406A1

公开(公告)日：2019-04-11

申请号：US16086698

申请日：2017-04-07

申请人： UCB Biopharma SPRL

发明人： Ali Ates ,  Eric Jnoff ,  Laurent Provins ,  Anne Valade ,  Adrian Hall

IPC分类号： C07D401/06 ,  C07D471/04

CPC分类号： C07D401/06 ,  C07D217/06 ,  C07D403/06 ,  C07D471/04

摘要： The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), wherein G represents a fused heterocyclic system selected from the groups represented by formula (G1), (G2), (G3), (G4), (G5), and (G6), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US20220213103A1

公开(公告)日：2022-07-07

申请号：US17700075

申请日：2022-03-21

申请人： UCB Biopharma SPRL

发明人： Joel Mercier ,  Laurent Provins ,  Celine Vermeiren ,  Yogesh Anil Sabnis

IPC分类号： C07D471/14 ,  A61K51/04 ,  C07B59/00

摘要： The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.

公开(公告)号：US10370355B2

公开(公告)日：2019-08-06

申请号：US16086698

申请日：2017-04-07

申请人： UCB Biopharma SPRL

发明人： Ali Ates ,  Eric Jnoff ,  Laurent Provins ,  Anne Valade ,  Adrian Hall

IPC分类号： C07D401/06 ,  C07D471/04

摘要： The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), wherein G represents a fused heterocyclic system selected from the groups represented by formula (G1), (G2), (G3), (G4), (G5), and (G6), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.