公开(公告)号：US20190298859A1

公开(公告)日：2019-10-03

申请号：US16337243

申请日：2017-09-27

Applicant: UCB Biopharma SPRL

Inventor： Terence Seward Baker ,  Michael Anthony William Eaton ,  Timothy John Norman ,  James Petrie Turner

IPC: A61K48/00 ,  C07F9/10 ,  C07F9/117 ,  C07F9/12 ,  C07J51/00

Abstract: Compounds of formula (I), wherein Ar is an aryl group optionally further substituted with one or more groups R3; A is a lipophilic, hydrophobic moiety; R1 is a phosphodiester, phosphotriester, thioether or amide group; X is an unsubstituted or substituted C6 to C24 alkylene or alkenylene group, which is optionally interrupted by one or more —NR9—, —O— or —S— linkages, R2 is —YC(R4)(R5)CO2R6; and pharmaceutically acceptable salts or solvates thereof are useful as endosomolytic agents particularly for the delivery of nucleic acids useful in gene therapy.